Overview

Through the Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, NIH supports research to enhance pain management and improve treatment for opioid misuse and addiction. The NIH HEAL Initiative includes research focus areas led by most NIH Institutes and Centers supporting hundreds of projects that reflect the full spectrum of research from basic science to implementation research.

HEAL Policy for the Enrollment of Participants in Clinical Trials

Clinical trials to identify and test new safe and effective treatment approaches for opioid use disorder and chronic pain are an essential component of HEAL research. To ensure that such clinical trials are conducted as safely and efficiently as possible, researchers must meet certain requirements when recruiting study participants. These requirements are specified in the HEAL Policy for the Enrollment of Participants in Clinical Trials, which also outlines the responsibilities of Principal Investigators and relevant NIH staff.

Read CT Enrollment Policy

Funded Projects

2023
Investigating Mechanisms Underpinning Outcomes in People on Opioid Agonist Treatment for OUD: Disentangling Sleep and Circadian Rhythm Influences on Craving and Emotion Regulation
Nov 28, 2023
2023
HEALing Measurement Center: Enhancing Opioid Use Disorder Recovery Through Measurement Based Care
Nov 28, 2023
2023
Developing and Testing Innovative Care Pathways for Screening and Treatment of OUD/PTSD in Jails
Nov 28, 2023
2023
Validation of a Virtual Still Face Procedure and Deep Learning Algorithms to Assess Infant Emotion Regulation and Infant-Caregiver Interactions in the Wild
Nov 28, 2023
2023
Endosomal Mechanisms Signaling Oral Cancer Pain
Nov 28, 2023

Open Funding Opportunities

2023
HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 - Clinical Trial Optional)
Aug 11, 2023
2023
Notice of Intent to Publish a Notice of Funding Opportunity for the HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain Program Resource and Data Center (U24 Clinical Trial Not Allowed)
Jul 01, 2023
2023
Notice of Intent to Publish a Notice of Funding Opportunity for the HEAL Initiative: KIDS Acute Pain Clinical Trials (APCT) Program (U01 Clinical Trial Required)
Jul 01, 2023
2023
HEAL Initiative: Native Collective Research Effort to Enhance Wellness (N CREW) Program - Addressing Overdose, Substance Use, Mental Health, and Pain Native Research Resource Network (OT2)
Jun 23, 2023
2023
HEAL Initiative: Native Collective Research Effort to Enhance Wellness (N CREW) Program - Addressing Overdose, Substance Use, Mental Health, and Pain (OT2)
Jun 23, 2023

Closed Funding Opportunities

2022
HEAL Initiative: EPPIC-Net Pain Research Asset Application – Dossier (OT1) [ROLLING SUBMISSION ACCEPTED: BY INVITATION ONLY]
Jun 03, 2022
2022
HEAL Initiative: EPPIC-Net Pain Research - Application for Clinical Trial and Related Activities (OT2) [ROLLING SUBMISSION ACCEPTED: BY INVITATION ONLY]
Jun 03, 2022
2022
HEAL Initiative: Multilevel Interventions to Reduce Harm and Improve Quality of Life for Patients on Long Term Opioid Therapy (MIRHIQL) (R01 Clinical Trial Required)
Jul 11, 2022
2022
HEAL Initiative: Multilevel Interventions to Reduce Harm and Improve Quality of Life for Patients on Long Term Opioid Therapy (MIRHIQL): Resource Center (U24- Clinical Trial Optional)
Jul 11, 2022
2020
HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional)
Jan 23, 2020