Overview

Through the Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, NIH supports research to enhance pain management and improve treatment for opioid misuse and addiction. The NIH HEAL Initiative includes research focus areas led by most NIH Institutes and Centers supporting hundreds of projects that reflect the full spectrum of research from basic science to implementation research.

Funded Projects

2022
Total-Body PET for Assessing Myofascial Pain
Oct 01, 2022
2022
Phase 1 and 2 Studies of Sublingual Dexmedetomidine, an Alpha 2 Adrenergic Agonist, for Treating Opioid Withdrawal
Oct 01, 2022
2022
The Effects of Hydrocodone Rescheduling on Pain Management of Older Lung Cancer Patients
Oct 01, 2022
2022
Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment of Pain (CBOT-P)
Oct 01, 2022
2022
Fibromyalgia TENS in Physical Therapy Study (TIPS): An Embedded Pragmatic Clinical Trial
Oct 01, 2022

Open Funding Opportunities

2022
HEAL Initiative: Research to Foster an Opioid Use Disorder Treatment System Patients Can Count On (RM1 - Clinical Trial Optional)
Sep 06, 2022
2022
Grand Opportunity in Medications Development for Substance-Use Disorders (U01 Clinical Trial Optional)
Sep 01, 2022
2022
Development of Medications to Prevent and Treat Opioid and/or Stimulant Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
Sep 01, 2022
2022
HEAL Initiative: Opioid Exposure and Effects on Placenta Function, Brain Development, and Neurodevelopmental Outcomes (R21 Clinical Trial Not Allowed)
Aug 29, 2022
2022
HEAL Initiative: Opioid Exposure and Effects on Placenta Function, Brain Development, and Neurodevelopmental Outcomes (R01 Basic Experimental Studies with Humans Required)
Aug 29, 2022

Closed Funding Opportunities

2020
HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional)
Jan 23, 2020
2021
HEAL Initiative: HEAL Data2Action Modeling and Economic Resource Center (U24 Clinical Trial Optional)
Dec 30, 2021
2021
HEAL Initiative: HEAL Data2Action Innovation Projects (R61/R33 Clinical Trial Optional)
Dec 30, 2021
2021
HEAL Initiative: HEAL Data2Action (HD2A) Data Infrastructure Support Center (U24 Clinical Trial Optional)
Dec 30, 2021
2021
HEAL Initiative: Pilot & Feasibility Trials to Improve Prevention and Treatment Service Delivery for Polysubstance Use (R34-Clinical Trial Optional)
Dec 29, 2021