This page is in the process of being updated. Contact [email protected] for more information.

Fiscal Years 2018-2021 Budget for the NIH HEAL Initiative*

Administrative Supplements for Additional Targets Within the Understudied Druggable Genome

Institute(s): NCATS

Budget: $1.3 million

Administrative Supplements to Enhance Diversity

Institute(s): NINDS

Budget: $2.7 million

Advancing Clinical Trials for Neonatal Opioid Withdrawal (ACT NOW)

Institute(s): NICHD

Budget: $48.5 million

Analgesic Development for Pain Management

Institute: NINDS

Budget: $11.5 million

Back Pain Research Consortium (BACPAC)

Institute(s): NIAMS

Budget: $130.5 million

Behavioral Research to Improve Medication-Based Treatment (Previously “Behavioral Interventions for Prevention of Opioid Use Disorder or Adjunct to Medication Assisted Treatment-SAMHSA Opioid State Targeted Response Grants”)

Institute(s): NCCIH

Budget: $33 million

Central Data Resource/Ecosystem

Institute(s): OD

Budget: $20.5 million

Comparative-Effectiveness Trial for the Pharmacological Treatment of Neonatal Opioid Withdrawal Syndrome

Institute(s): NICHD

Budget: $7 million

Development of Novel Immunotherapeutics for Opioid Addiction

Institute(s): NIAID

Budget: $28 million

Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain (Previously “Biomarkers, Endpoints, and Signatures for Pain Conditions”)

Institute(s): NINDS

Budget: $69 million

Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions

Institute(s): NINDS

Budget: $31.7 million

Early Phase Pain Investigation Network (EPPIC-Net)

Institute(s): NINDS

Budget: $50.1 million

Enhancing Career Development in Clinical Pain Research

Institute: NINDS

Budget: $2.7 million

Enhancing the National Drug Abuse Treatment Clinical Trials Network to Address Opioids (Previously “National Drug Abuse Treatment Clinical Trials Network Enhancement”)

Institute(s): NIDA

Budget: $162.2 million

Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose (Previously “Focused Medications Development to Treat Opioid Use Disorder and Prevent/Reverse Overdose”)

Institute(s): NIDA

Budget: $330 million

HEALthy Brain and Child Development Study (HBCD)


Budget: $24.6 million

HEALing Communities Study

Institute(s): NIDA

Budget: $305.7 million

Integrated Approach to Pain and Opioid Use in Hemodialysis Patients

Institute(s): NIDDK

Budget: $28.5 million

Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR)

Institute: NIDA

Budget: $19.7 million

Justice Community Opioid Innovation Network

Institute(s): NIDA

Budget: $105.4 million

Opioid Use Disorder Small Business Innovation Research/Small Business Technology Transfer Research

Institute(s): NIDA

Budget: $36.8 million

Optimizing Care for People with Opioid Use Disorder and Mental Health Conditions (Previously “Optimizing Collaborative Care for Patients with Opioid Use Disorders and Common Mental Disorders”)

Institute(s): NIMH

Budget: $60.6 million

Optimizing the Duration, Retention, and Discontinuation of Medication Treatment for Opioid Use Disorder (Previously “Determining the Optimal Length of Buprenorphine Treatment”)

Institute(s): NIDA

Budget: $33.9 million

Pain Management Effectiveness Research Network

Institute(s): NCATS, NINDS

Budget: $80.3 million

Pain Small Business Innovation Research/Small Business Technology Transfer Research

Institute(s): NINDS

Budget: $48.9 million

Pain Therapeutic Development Program (Previously “Development and Optimization of Non-Addictive Therapies to Treat Pain”)

Institute: NINDS

Budget: $14.4 million

Patient Engagement nd Diversity and Inclusion

Institute(s): NINDS

Budget: $7.1 million

Peer Navigator Support to Existing HEAL Studies

Institute(s): NIDA

Budget: $3.9 million                  

Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM)

Institute(s): NCCIH, NIAMS

Budget: $32 million

Preclinical Screening Platform for Pain (Previously “Engineering a Preclinical Testing Platform to Identify and Profile Non-Addictive Therapeutics for Pain”)

Institute(s): NINDS

Budget: $31 million

Preventing Opioid Use Disorder (Previously “Preventing At-Risk Adolescents from Developing Opioid Use Disorder as They Transition into Adulthood”)

Institute(s): NIDA, NIAAA

Budget: $57.3 million

Prevention of Progression to Moderate or Severe Opioid Use Disorder

Institute: NIDA

Budget: $9.4 million

Recovery Research Networks

Institute: NIDA

Budget: $4.9 million

Safety and Efficacy of ANS-6637 to Reduce Drug Craving and Harm (SEARCH) in People with Opioid Use Disorder in Highly Affected Urban Populations

Institute(s): NIAID

Budget: $3.9 million

Sleep Dysfunction as a Core Feature of Opioid Use Disorder and Recovery (Previously “Sleep Dysfunction as a Core Feature of Opioid Use Disorder and a Potential Target for Facilitating Recovery”)

Institute(s): NHLBI

Budget: $25.7 million

Strategies to Reduce Stigma in Pain Management and OUD and Addiction Treatment

Institute(s): OBSSR

Budget: $1.7 million

Translating Discoveries into Effective Devices for Pain Treatment

Institute(s): NINDS, NIBIB, OD

Budget: $28.2 million

Translational Research to Advance Testing of Novel Drugs and Human Cell-Based Screening Platforms to Treat Pain and Opioid Use Disorder (Previously “Development of Novel Drugs and Human Cell-Based Screening Platforms to Treat Pain and Opioid Use Disorder”)

Institute(s): NCATS

Budget: $99.5 million

TOTAL: $2 billion

*The Acute to Chronic Pain Signatures and Stimulating Peripheral Activity to Relieve Conditions (SPARC) programs are supported by the NIH Common Fund and do not appear on this page.