Research Programs

This program seeks to validate novel therapeutic targets using a variety of methods and model systems. These targets can be applied to future translational research to speed up the creation of effective non-addictive medications for pain and reduce reliance on opioids. 

The Preclinical Screening Platform for Pain (PSPP) program will create a preclinical testing platform to identify and profile non-addictive therapeutics for pain. This platform will be instrumental in transitioning NIH HEAL Initiative preclinical research into clinical programs.

The NIH HEAL Initiative will support research to develop more accurate research models, use these models to identify potential new therapies, and accelerate studies of novel small molecule and biologic drug candidates for testing in humans.

The NIH HEAL Initiative will support preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics to treat pain. 

The NIH HEAL Initiative will advance device-based treatments for people who currently have no effective ways to manage their pain. Research will support target identification, late-stage translational therapeutic and diagnostic device development, verification and validation activities, and early clinical studies.

Through a robust multidisciplinary and trans-NIH project, the NIH HEAL Initiative will advance the discovery and rigorous validation of biomarkers for pain research and treatment. Successful development of biomarkers could help increase the use of biomarkers for patient selection in clinical trials. This could improve the efficacy of clinical trials and increase the chance that new therapeutics will advance to approval.

Funded Projects

2020
AIBP AND REGULATION OF NEUROPATHIC PAIN
Mar 19, 2020
2020
AIBP and regulation of neuropathic pain
Mar 19, 2020
2020
BEYOND PHEWAS: RECOGNITION OF PHENOTYPE PATTERNS FOR DISCOVERY AND TRANSLATION - ADMINISTRATIVE SUPPLEMENT
Mar 19, 2020
2020
Biomarker Signature to Predict the Persistence of Post-Traumatic Headache
Mar 19, 2020
2020
Using Virtual Reality Psychological Therapy to Develop a Non-Opioid Chronic Pain Therapy
Mar 19, 2020

Open Funding Opportunities

2019
HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed)
Oct 03, 2019
2019
HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Required)
Oct 04, 2019
2019
HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 - Clinical Trial Not Allowed)
Oct 04, 2019
2019
HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 - Clinical Trial Required)
Oct 04, 2019
2020
2020 NCATS ASPIRE Reduction-to-Practice Challenge
Sep 30, 2020

Closed Funding Opportunities

2019
HEAL Initiative: Clinical Devices to Treat Pain (UH3 Clinical Trial Optional)
Sep 25, 2019
2019
HEAL Initiative: Translational Development of Devices to Treat Pain (U18 Clinical Trial Not Allowed)
Sep 25, 2019
2019
HEAL Initiative: Translational Devices to Treat Pain (U44 Clinical Trial Optional)
Sep 25, 2019
2019
HEAL Initiative: Translational Devices to Treat Pain (UG3/UH3 Clinical Trial Optional)
Sep 25, 2019
2019
HEAL Initiative: Announcement of the NCATS ASPIRE Design Challenges to Develop Innovative and Catalytic Approaches Towards Solving the Opioid Crisis
Sep 25, 2019

Collaboration Opportunities for Developing Drugs and Human Cell-Based Testing Platforms for Pain, Addiction and Overdose

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National Institutes of Health, Office of Extramural Research. Grants & Funding. NIH's central resource for grants and funding information.

Collaboration Opportunities for Developing Drugs and Human Cell-Based Testing Platforms for Pain, Addiction and Overdose

The NIH Helping to End Addiction Long-termSM Initiative, or NIH HEAL InitiativeSM, seeks to speed scientific solutions to the national opioid public health crisis.

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