U.S. Department of Health & Human Services
NIH HEAL Initiative Annual Report and Budget
The NIH HEAL Initiative® is committed to an accelerated research timeline and maximal transparency based upon the urgency of the opioid crisis. Initiative research is funded by NIH Institutes and Centers. Research results are shared immediately and broadly, according to the HEAL Public Access and Data Sharing Policy.
HEAL Annual Report
The NIH HEAL Initiative Annual Report details high-level areas of progress to the evolving opioid crisis and accomplishments achieved each fiscal year.
NIH HEAL Initiative 2025 Annual Report
HEAL’s mission to understand and treat both addiction and pain requires a massive multi-disciplinary approach. The HEAL initiative is now seeing the dividends of tremendous research investments. Some of the work highlighted in this year’s report includes:
- Therapeutic agents moving through the drug development pipeline, including for pain, overdose, and opioid use disorder
- New ways to study human tissues, a key step in developing new therapies
- Implementation studies improving care for patients using existing treatments
- Efforts to bring critical treatments to high-needs patients, including rural populations and new mothers
- Curation of a large data ecosystem, which will facilitate future discoveries
Previous Annual Reports
HEAL Budget
NIH HEAL Initiative research is administered each fiscal year by several NIH Institutes and Centers.
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Open Funding Opportunities
The NIH HEAL Initiative® funds work in research focus areas led by most NIH ICs supporting hundreds of projects, from basic science to implementation research.
Research Programs
Research from the Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, includes over 31 distinct programs. These programs are led by most NIH Institutes, Centers, and Offices.