Overview

Through the Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, NIH supports research to enhance pain management and improve treatment for opioid misuse and addiction. The NIH HEAL Initiative includes research focus areas led by most NIH Institutes and Centers supporting hundreds of projects that reflect the full spectrum of research from basic science to implementation research.

Funded Projects

2021
Building a Lasting Foundation to Advance Actionable Research on Recovery Support Services for High Risk Individuals with Opioid Use Disorder: The Initiative for Justice and Emerging Adult Populations
Summary
Summary
Nov 11, 2021
2021
Studies to Advance Recovery Supports (STARS) in Central Appalachia
Summary
Summary
Nov 11, 2021
2021
Advancing the science on recovery community centers to support persons treated with medications for opioid use disorder
Summary
Summary
Nov 11, 2021
2021
Development of cannabinoid-opioid combination with opioid sparing and synergistic analgesic effects to prevent opioid use disorder and overdose
Summary
Summary
Oct 12, 2021
2021
Quantifying How Cocaine Users Respond to Fentanyl Contamination in Cocaine
Summary
Summary
Oct 12, 2021

Open Funding Opportunities

2022
HEAL Initiative: Research to Foster an Opioid Use Disorder Treatment System Patients Can Count On (RM1 - Clinical Trial Optional)
FOA Link
FOA Link
Sep 06, 2022
2022
Grand Opportunity in Medications Development for Substance-Use Disorders (U01 Clinical Trial Optional)
FOA Link
FOA Link
Sep 01, 2022
2022
Development of Medications to Prevent and Treat Opioid and/or Stimulant Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
FOA Link
FOA Link
Sep 01, 2022
2022
HEAL Initiative: Opioid Exposure and Effects on Placenta Function, Brain Development, and Neurodevelopmental Outcomes (R01 Basic Experimental Studies with Humans Required)
FOA Link
FOA Link
Aug 29, 2022
2022
HEAL Initiative: Opioid Exposure and Effects on Placenta Function, Brain Development, and Neurodevelopmental Outcomes (R01 Clinical Trial Not Allowed)
FOA Link
FOA Link
Aug 29, 2022

Closed Funding Opportunities

2020
HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional)
FOA Link
FOA Link
Jan 23, 2020
2021
HEAL Initiative: HEAL Data2Action Innovation Projects (R61/R33 Clinical Trial Optional)
FOA Link
FOA Link
Dec 30, 2021
2021
HEAL Initiative: HEAL Data2Action (HD2A) Data Infrastructure Support Center (U24 Clinical Trial Optional)
FOA Link
FOA Link
Dec 30, 2021
2021
HEAL Initiative: HEAL Data2Action Modeling and Economic Resource Center (U24 Clinical Trial Optional)
FOA Link
FOA Link
Dec 30, 2021
2021
HEAL Initiative: Planning Grants for Efficacy or Effectiveness Trials of Recovery Support Services for Individuals Treated with Medications for Opioid Use Disorder (R34 Clinical Trial Optional)
FOA Link
FOA Link
Dec 29, 2021