Overview

Through the Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, NIH supports research to enhance pain management and improve treatment for opioid misuse and addiction. The NIH HEAL Initiative includes research focus areas led by most NIH Institutes and Centers supporting hundreds of projects that reflect the full spectrum of research from basic science to implementation research.

HEAL Policy for the Enrollment of Participants in Clinical Trials

Clinical trials to identify and test new safe and effective treatment approaches for opioid use disorder and chronic pain are an essential component of HEAL research. To ensure that such clinical trials are conducted as safely and efficiently as possible, researchers must meet certain requirements when recruiting study participants. These requirements are specified in the HEAL Policy for the Enrollment of Participants in Clinical Trials, which also outlines the responsibilities of Principal Investigators and relevant NIH staff.

Read CT Enrollment Policy

Funded Projects

2023
Sleep and Circadian Rhythm Phenotypes and Mechanisms Associated With Opioid Use Disorder Treatment Outcomes
Summary
Summary
Nov 28, 2023
2023
Data-Driven Approaches for Opioid Use Disorder Treatment, Recovery, and Overdose Prevention in Rural Communities via Mobile Health Clinics and Peer Support Services
Summary
Summary
Nov 28, 2023
2023
Testing a Video and Text Messaging Intervention to Reduce PTSD and Opioid Misuse Among Sexual Violence Survivors
Summary
Summary
Nov 28, 2023
2023
Autonomous Digital CBT Intervention for Opioid Use Disorder in Individuals with Co-Occurring Internalizing Disorders
Summary
Summary
Nov 28, 2023
2023
Validation of a New Large-Pore Channel as a Novel Target for Neuropathic Pain
Summary
Summary
Nov 28, 2023

Open Funding Opportunities

2023
HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 - Clinical Trial Optional)
NOFO Link
NOFO Link
Aug 11, 2023
2023
HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional)
NOFO Link
NOFO Link
Apr 27, 2023
2023
HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (SB1 Clinical Trial Not Allowed)
NOFO Link
NOFO Link
Jan 03, 2023
2022
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research (K99/R00 Independent Clinical Trial Not Allowed)
NOFO Link
NOFO Link
Dec 15, 2022
2022
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed)
NOFO Link
NOFO Link
Dec 15, 2022

Closed Funding Opportunities

2022
HEAL Initiative: EPPIC-Net Pain Research Asset Application – Dossier (OT1) [ROLLING SUBMISSION ACCEPTED: BY INVITATION ONLY]
NOFO Link
Jun 03, 2022
NOFO Link
2022
HEAL Initiative: EPPIC-Net Pain Research - Application for Clinical Trial and Related Activities (OT2) [ROLLING SUBMISSION ACCEPTED: BY INVITATION ONLY]
NOFO Link
Jun 03, 2022
NOFO Link
2022
HEAL Initiative: Multilevel Interventions to Reduce Harm and Improve Quality of Life for Patients on Long Term Opioid Therapy (MIRHIQL) (R01 Clinical Trial Required)
NOFO Link
Jul 11, 2022
NOFO Link
2022
HEAL Initiative: Multilevel Interventions to Reduce Harm and Improve Quality of Life for Patients on Long Term Opioid Therapy (MIRHIQL): Resource Center (U24- Clinical Trial Optional)
NOFO Link
Jul 11, 2022
NOFO Link
2020
HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional)
NOFO Link
Jan 23, 2020
NOFO Link