Overview

Through the Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, NIH supports research to enhance pain management and improve treatment for opioid misuse and addiction. The NIH HEAL Initiative includes research focus areas led by most NIH Institutes and Centers supporting hundreds of projects that reflect the full spectrum of research from basic science to implementation research.

Funded Projects

2022
The Spine Phenome Project: Enhancing Patient Diversity
Summary
Summary
Oct 01, 2022
2022
Injectable Ice Slurry Cooling Technology for Treatment of Postoperative Pain
Summary
Summary
Oct 01, 2022
2022
Total-Body PET for Assessing Myofascial Pain
Summary
Summary
Oct 01, 2022
2022
Phase 1 and 2 Studies of Sublingual Dexmedetomidine, an Alpha 2 Adrenergic Agonist, for Treating Opioid Withdrawal
Summary
Summary
Oct 01, 2022
2022
The Effects of Hydrocodone Rescheduling on Pain Management of Older Lung Cancer Patients
Summary
Summary
Oct 01, 2022

Open Funding Opportunities

2023
Notice of Intent to Publish a Notice of Funding Opportunity for the HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain Program Resource and Data Center (U24 Clinical Trial Not Allowed)
FOA Link
Jul 01, 2023
FOA Link
2023
Notice of Intent to Publish a Notice of Funding Opportunity for the HEAL Initiative: KIDS Acute Pain Clinical Trials (APCT) Program (U01 Clinical Trial Required)
FOA Link
Jul 01, 2023
FOA Link
2023
HEAL Initiative Partnerships to Advance INterdisciplinary (PAIN) Training in Clinical Pain Research: The HEAL PAIN Cohort Program (T90/R90 Independent Clinical Trial Not Allowed)
FOA Link
May 09, 2023
FOA Link
2023
HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional)
FOA Link
Apr 27, 2023
FOA Link
2023
Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed)
FOA Link
Apr 20, 2023
FOA Link

Closed Funding Opportunities

2022
HEAL Initiative: EPPIC-Net Pain Research - Application for Clinical Trial and Related Activities (OT2) [ROLLING SUBMISSION ACCEPTED: BY INVITATION ONLY]
FOA Link
Jun 03, 2022
FOA Link
2022
HEAL Initiative: EPPIC-Net Pain Research Asset Application – Dossier (OT1) [ROLLING SUBMISSION ACCEPTED: BY INVITATION ONLY]
FOA Link
Jun 03, 2022
FOA Link
2022
HEAL Initiative: Multilevel Interventions to Reduce Harm and Improve Quality of Life for Patients on Long Term Opioid Therapy (MIRHIQL): Resource Center (U24- Clinical Trial Optional)
FOA Link
Jul 11, 2022
FOA Link
2022
HEAL Initiative: Multilevel Interventions to Reduce Harm and Improve Quality of Life for Patients on Long Term Opioid Therapy (MIRHIQL) (R01 Clinical Trial Required)
FOA Link
Jul 11, 2022
FOA Link
2020
HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional)
FOA Link
Jan 23, 2020
FOA Link