Overview

Through the Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, NIH supports research to enhance pain management and improve treatment for opioid misuse and addiction. The NIH HEAL Initiative includes research focus areas led by most NIH Institutes and Centers supporting hundreds of projects that reflect the full spectrum of research from basic science to implementation research.

HEAL Policy for the Enrollment of Participants in Clinical Trials

Clinical trials to identify and test new safe and effective treatment approaches for opioid use disorder and chronic pain are an essential component of HEAL research. To ensure that such clinical trials are conducted as safely and efficiently as possible, researchers must meet certain requirements when recruiting study participants. These requirements are specified in the HEAL Policy for the Enrollment of Participants in Clinical Trials, which also outlines the responsibilities of Principal Investigators and relevant NIH staff.

Read CT Enrollment Policy

Funded Projects

2023
Building Social and Structural Connections for the Prevention of OUD Among Youth Experiencing Homelessness: An RCT Examining Biopsychosocial Mechanisms
Nov 28, 2023
2023
Person-Centered Quality Measurement and Management in a System for Addictions Treatment in New York State
Nov 28, 2023
2023
Onsite PTSD Treatment to Improve MOUD Outcomes (OPTIMO): A Hybrid Type 1 Effectiveness-Implementation Trial of Harm Reduction PTSD Care at Syringe Service Programs
Nov 28, 2023
2023
Automated Assessment of Maternal Sensitivity to Infant Distress: Leveraging Wearable Sensors for Substance Use Disorder Prevention and Research
Nov 28, 2023
2023
Meaningful Data Integration, Visualization and Distribution for Human Pain Associated Genes & Cells Datasets
Nov 28, 2023

Open Funding Opportunities

2023
HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 - Clinical Trial Optional)
Aug 11, 2023
2023
HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (SB1 Clinical Trial Not Allowed)
Jan 03, 2023
2022
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research to Promote Diversity (K99/R00 Independent Basic Experimental Studies with Humans Required)
Dec 15, 2022
2022
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research (K99/R00 Independent Clinical Trial Not Allowed)
Dec 15, 2022
2022
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed)
Dec 15, 2022

Closed Funding Opportunities

2023
HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional)
Apr 27, 2023
2022
HEAL Initiative: EPPIC-Net Pain Research - Application for Clinical Trial and Related Activities (OT2) [ROLLING SUBMISSION ACCEPTED: BY INVITATION ONLY]
Jun 03, 2022
2022
HEAL Initiative: EPPIC-Net Pain Research Asset Application – Dossier (OT1) [ROLLING SUBMISSION ACCEPTED: BY INVITATION ONLY]
Jun 03, 2022
2022
HEAL Initiative: Multilevel Interventions to Reduce Harm and Improve Quality of Life for Patients on Long Term Opioid Therapy (MIRHIQL) (R01 Clinical Trial Required)
Jul 11, 2022
2022
HEAL Initiative: Multilevel Interventions to Reduce Harm and Improve Quality of Life for Patients on Long Term Opioid Therapy (MIRHIQL): Resource Center (U24- Clinical Trial Optional)
Jul 11, 2022