Open Funding Opportunities

NOFO # NOFO Title Research Focus Area Earliest Submission Date Expiration Date Posted Date Sort ascending
RFA-NS-25-012
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Sat, 05/18/2024 Sat, 01/16/2027 Tue, 03/26/2024

This notice of funding opportunity (NOFO) aims to encourage research grant applications for initial translational efforts that will enable a drug discovery program for novel, non-opioid, and non-addictive treatments for pain. The program provides funding to develop and validate assays to support a distinct testing funnel and conduct screening efforts to identify and characterize potential therapeutic agents including small molecules, biologics, and natural products. Preliminary in vivo pharmacokinetic, pharmacodynamic, and efficacy studies may also be supported. The goal of this NOFO is to advance projects to the point where they meet the entry criteria for the Pain Therapeutics Development Program or other later-stage translational programs.

RFA-NS-24-019
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional) Preclinical and Translational Research in Pain Management Sun, 12/24/2023 Fri, 01/08/2027 Wed, 11/01/2023

The purpose of this notice of funding opportunity (NOFO) is to support preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics to treat pain. The goal of the program is to accelerate the optimization and development of promising early therapeutic molecules and to facilitate readiness for the Early Phase Pain Investigation Clinical Network (EPPIC-Net) or other Phase II clinical studies.

RFA-DA-24-067
HEAL Initiative: Research to Increase Implementation of Substance Use Preventive Services (R01 Clinical Trial Optional) New Strategies to Prevent and Treat Opioid Addiction Sun, 12/17/2023 Sat, 01/17/2026 Fri, 09/22/2023

Despite an evidence base of effective programs to prevent the initiation of substance use, misuse and disorder, a substantial research to practice gap exists. The goal of this initiative is to support projects that fill this research to practice gap, improving public health and responding to the opioid crisis by increasing knowledge pertaining to the delivery of prevention services. This notice of funding opportunity (NOFO) solicits applications to address understudied areas of opportunity that, if researched, could create the foundation needed to inform a prevention infrastructure for ongoing delivery and sustainment of interventions to prevent opioid and other substance misuse and use disorders. This NOFO invites projects for which preliminary or feasibility data is available. This NOFO is a companion to RFA-DA-24-066 which solicits applications for which pilot data is unavailable.

RFA-DA-24-066
HEAL Initiative: Research to Increase Implementation of Substance Use Preventive Services (R61/R33 Clinical Trial Optional) New Strategies to Prevent and Treat Opioid Addiction Sun, 12/17/2023 Sat, 01/17/2026 Fri, 09/22/2023

Despite an evidence base of effective programs to prevent the initiation of substance use, misuse and disorder, a substantial research to practice gap exists. The goal of this initiative is to support projects that fill this research to practice gap, improving public health and responding to the opioid crisis by increasing knowledge pertaining to the delivery of prevention services. This notice of funding opportunity (NOFO) solicits applications to address understudied areas of opportunity that, if researched, could create the foundation needed to inform a prevention infrastructure for ongoing delivery and sustainment of interventions to prevent opioid and other substance misuse and use disorders. This NOFO invites projects for which preliminary or feasibility data is not available. This NOFO is a companion to RFA-DA-24-067 which solicits applications for which pilot data is available.

RFA-NS-24-021
HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 - Clinical Trial Optional) Preclinical and Translational Research in Pain Management Sat, 10/07/2023 Fri, 02/07/2025 Fri, 08/11/2023

This notice of funding opportunity (NOFO) seeks to support research aimed at holistic understanding of inter-individual or between-person differences in human pain conditions, focusing  on ‘Whole Person Health’ and enhancing pain treatment and management strategies towards personalized pain medicine. The goal of this NOFO is to support studies that focus on the collection of clinical and/or preclinical data to enable evidence-based modeling and understanding of inter-individual differences and/or heterogeneity of pain occurring with use of pain therapy/management, or with conditions such as a second pain condition, a comorbid health condition, a comorbid mental health condition, or conditions of use / misuse of opioids, alcohol or other substances.

PAR-23-069
HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (SB1 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Sun, 03/05/2023 Sat, 09/06/2025 Tue, 01/03/2023

The purpose of this Notice of Funding Opportunity (NOFO) is to facilitate the transition of previously funded SBIR and STTR Phase II and Phase IIB projects in pain management to the commercialization stage by providing additional assistance for private partnering activities through the Commercialization Readiness Pilot (CRP) program. Specifically, this NOFO supports the addition of entrepreneurial expertise into small business leadership teams along with supporting partnering activities to aid in commercialization through private third-party funding or partnership with industry.

Clinical trials are not accepted under this NOFO.

RFA-NS-22-024
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research to Promote Diversity (K99/R00 Independent Basic Experimental Studies with Humans Required) Cross-Cutting Research Tue, 01/10/2023 Wed, 03/12/2025 Thu, 12/15/2022

The purpose of this NIH HEAL Initiative® Pathway to Independence Award (K99/R00) program is to support a cohort of new and well-trained, independent investigators from diverse backgrounds (e.g. see NOT-OD-20-031, Notice of NIH’s Interest in Diversity) conducting Pain and/or SUD research, in order to promote a diverse pool of available independent investigators working in research areas supported by the NIH HEAL Initiative®. This program is designed to facilitate a timely transition of eligible postdoctoral researchers from their mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition to help awardees establish independent research programs in areas supported by the NIH HEAL Initiative®.

This Notice of Funding Opportunity is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as “prospective basic science studies involving human participants.” These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should be submitted under this NOFO include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Applicants not planning an independent clinical trial or basic experimental study with humans, or proposing to gain research experience in a clinical trial or basic experimental study with humans led by another investigator, must apply to the 'Independent Clinical Trial Not Allowed' companion NOFO.

The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.

RFA-NS-22-022
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research (K99/R00 Independent Clinical Trial Not Allowed) Cross-Cutting Research Tue, 01/10/2023 Wed, 03/12/2025 Thu, 12/15/2022

The purpose of the NIH HEAL Initiative® Pathway to Independence Award (K99/R00) program is to support a cohort of new and well-trainedindependent investigators conducting Pain and/or SUD research, in order to increase the independent investigator workforce in research areas supported by the NIH HEAL Initiative®. This program is designed to facilitate a timely transition of eligible postdoctoral researchers from their mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition to help awardees establish independent research programs in areas supported by the NIH HEAL Initiative®.

This Notice of Funding Opportunity (NOFO) is designed specifically for candidates proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, an ancillary study to a clinical trial, or an independent Basic Experimental Studies with Humans (BESH). Applicants to this NOFO are permitted to propose research experience in a clinical trial led by a mentor or co-mentor. Those proposing an independent BESH as lead investigator, should apply to the companion NOFO (RFA-NS-22-023).

RFA-NS-22-025
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed) Cross-Cutting Research Thu, 12/15/2022 Sat, 03/15/2025 Thu, 12/15/2022

The purpose of this NIH HEAL Initiative® Pathway to Independence Award (K99/R00) program is to support a cohort of new and well-trained, independent investigators from diverse backgrounds (e.g. see NOT-OD-20-031, Notice of NIH’s Interest in Diversity) conducting Pain and/or SUD research, in order to promote a diverse pool of available independent investigators working in research areas supported by the NIH HEAL Initiative®. This program is designed to facilitate a timely transition of eligiblepostdoctoral researchers from their mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition to help awardees establish independent research programs in areas supported by the NIH HEAL Initiative®.

This Funding Opportunity Announcement (FOA) is designed specifically for candidates proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, an ancillary study to a clinical trial, or an independent Basic Experimental Studies with Humans (BESH). Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor. Those proposing an independent BESH as lead investigator, should apply to the companion FOA (RFA-NS-22-024).

RFA-NS-22-023
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research (Independent Basic Experimental Studies with Humans Required) Cross-Cutting Research Tue, 01/10/2023 Wed, 03/12/2025 Thu, 12/15/2022

The purpose of the NIH HEAL Initiative® Pathway to Independence Award (K99/R00) program is to support a cohort of new and well-trained independent investigators conducting Pain and/or SUD research, in order to increase the independent investigator workforce in research areas supported by the NIH HEAL Initiative®. This program is designed to facilitate a timely transition of eligible postdoctoral researchers from their mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition to help awardees establish independent research programs in areas supported by the NIH HEAL Initiative®.

This Notice of Funding Opportunity is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as “prospective basic science studies involving human participants.” These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should be submitted under this NOFO include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Applicants not planning an independent clinical trial or basic experimental study with humans, or proposing to gain research experience in a clinical trial or basic experimental study with humans led by another investigator, must apply to the 'Independent Clinical Trial Not Allowed' companion NOFO.

The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.

NOT-DA-23-009 Notice of Special Interest (NOSI): HEAL Initiative: Grand Opportunity in Medications Development for Substance-Use Disorders Novel Therapeutic Options for Opioid Use Disorder and Overdose Thu, 10/27/2022 Tue, 09/02/2025 Thu, 09/29/2022
no summary
NOT-DA-23-010 Notice of Special Interest (NOSI): HEAL Initiative: Development of Medications to Prevent and Treat Opioid and/or Stimulant Use Disorders and Overdose Novel Therapeutic Options for Opioid Use Disorder and Overdose Thu, 10/27/2022 Tue, 09/02/2025 Wed, 09/28/2022
no summary
RFA-NS-23-007 HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Sun, 12/04/2022 Sat, 04/05/2025 Thu, 09/15/2022
no summary
RFA-NS-23-006 HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Sun, 12/04/2022 Sat, 04/05/2025 Thu, 09/15/2022
no summary
PAR-22-202 Grand Opportunity in Medications Development for Substance-Use Disorders (U01 Clinical Trial Optional) Novel Therapeutic Options for Opioid Use Disorder and Overdose Sat, 09/03/2022 Tue, 09/02/2025 Thu, 09/01/2022
no summary
PAR-22-200 Development of Medications to Prevent and Treat Opioid and/or Stimulant Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional) Novel Therapeutic Options for Opioid Use Disorder and Overdose Sat, 09/03/2022 Tue, 09/02/2025 Thu, 09/01/2022
no summary
RFA-EB-22-002 HEAL Initiative: Translational Development of Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Fri, 10/14/2022 Wed, 06/18/2025 Tue, 08/23/2022
no summary
RFA-DA-23-053 HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional) Translation of Research to Practice for the Treatment of Opioid Addiction Fri, 10/14/2022 Fri, 03/21/2025 Wed, 08/03/2022
no summary
NOT-NS-23-002 Notice of Special Interest (NOSI): HEAL Initiative: Clinical Translation of Diagnostic and Therapeutic Devices via Blueprint MedTech Preclinical and Translational Research in Pain Management Tue, 10/18/2022 Fri, 06/21/2024 Wed, 08/03/2022
no summary
NOT-DA-23-007 Notice of Special Interest (NOSI): HEAL Initiative: Opioid Use Disorder Care Pathways for Individuals with Histories of Exposure to Violence Translation of Research to Practice for the Treatment of Opioid Addiction Wed, 10/12/2022 Sun, 07/13/2025 Wed, 08/03/2022
no summary
NOT-DA-23-008 Notice of Special Interest (NOSI) HEAL Initiative: Workforce Interventions to Improve Addiction Care Quality and Patient Outcomes Translation of Research to Practice for the Treatment of Opioid Addiction Wed, 10/05/2022 Mon, 09/08/2025 Wed, 08/03/2022
no summary
RFA-DA-23-054 HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R33 Clinical Trial Optional) Translation of Research to Practice for the Treatment of Opioid Addiction Fri, 10/14/2022 Fri, 03/21/2025 Wed, 08/03/2022
no summary
RFA-NS-23-003 HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional) Preclinical and Translational Research in Pain Management Sat, 09/10/2022 Tue, 06/10/2025 Mon, 08/01/2022
no summary
PAS-22-207 HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K23 - Clinical Trial Required) Translation of Research to Practice for the Treatment of Opioid Addiction Mon, 09/12/2022 Thu, 11/13/2025 Thu, 07/14/2022
no summary
NOT-NS-22-095 HEAL Initiative Notice of Special Interest (NOSI): Development and Validation of Pain-Related Models and Endpoints to Facilitate Non-Addictive Analgesic Discovery Preclinical and Translational Research in Pain Management Tue, 10/18/2022 Wed, 06/25/2025 Thu, 07/14/2022
no summary
PAS-22-206 HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K01 - Clinical Trial Required) Translation of Research to Practice for the Treatment of Opioid Addiction Mon, 09/12/2022 Thu, 11/13/2025 Thu, 07/14/2022
no summary
RFA-NS-22-034 HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Wed, 02/02/2022 Sat, 12/07/2024 Fri, 01/07/2022
no summary
NOT-NS-20-107
Notice of Special Interest to Encourage Eligible NIH HEAL Initiative Awardees to Apply for PA-20-222: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed) Cross-Cutting Research Sun, 11/15/2020 Thu, 05/16/2024 Mon, 10/19/2020

Diversity Supplement Guidance pdf  221.15 KB