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FOA # FOA Title Research Focus Area Earliest Submission Date Expiration Date Posted Date
PAR-23-069
HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (SB1 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Sun, 03/05/2023 Sat, 09/06/2025 Tue, 01/03/2023

The purpose of this Funding Opportunity Announcement (FOA) is to facilitate the transition of previously funded SBIR and STTR Phase II and Phase IIB projects in pain management to the commercialization stage by providing additional assistance for private partnering activities through the Commercialization Readiness Pilot (CRP) program. Specifically, this FOA supports the addition of entrepreneurial expertise into small business leadership teams along with supporting partnering activities to aid in commercialization through private third-party funding or partnership with industry.

Clinical trials are not accepted under this FOA.
RFA-NS-22-024
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research to Promote Diversity (K99/R00 Independent Basic Experimental Studies with Humans Required) Cross-Cutting Research Tue, 01/10/2023 Wed, 03/12/2025 Thu, 12/15/2022

The purpose of this NIH HEAL Initiative® Pathway to Independence Award (K99/R00) program is to support a cohort of new and well-trained, independent investigators from diverse backgrounds (e.g. see NOT-OD-20-031, Notice of NIH’s Interest in Diversity) conducting Pain and/or SUD research, in order to promote a diverse pool of available independent investigators working in research areas supported by the NIH HEAL Initiative®. This program is designed to facilitate a timely transition of eligible postdoctoral researchers from their mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition to help awardees establish independent research programs in areas supported by the NIH HEAL Initiative®.

This Funding Opportunity Announcement is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as “prospective basic science studies involving human participants.” These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should be submitted under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Applicants not planning an independent clinical trial or basic experimental study with humans, or proposing to gain research experience in a clinical trial or basic experimental study with humans led by another investigator, must apply to the 'Independent Clinical Trial Not Allowed' companion FOA.

The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.
RFA-NS-22-022
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research (K99/R00 Independent Clinical Trial Not Allowed) Cross-Cutting Research Tue, 01/10/2023 Wed, 03/12/2025 Thu, 12/15/2022

The purpose of the NIH HEAL Initiative® Pathway to Independence Award (K99/R00) program is to support a cohort of new and well-trainedindependent investigators conducting Pain and/or SUD research, in order to increase the independent investigator workforce in research areas supported by the NIH HEAL Initiative®. This program is designed to facilitate a timely transition of eligible postdoctoral researchers from their mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition to help awardees establish independent research programs in areas supported by the NIH HEAL Initiative®.

This Funding Opportunity Announcement (FOA) is designed specifically for candidates proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, an ancillary study to a clinical trial, or an independent Basic Experimental Studies with Humans (BESH). Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor. Those proposing an independent BESH as lead investigator, should apply to the companion FOA (RFA-NS-22-023).
RFA-NS-22-023
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research (Independent Basic Experimental Studies with Humans Required) Cross-Cutting Research Tue, 01/10/2023 Wed, 03/12/2025 Thu, 12/15/2022

The purpose of the NIH HEAL Initiative® Pathway to Independence Award (K99/R00) program is to support a cohort of new and well-trained independent investigators conducting Pain and/or SUD research, in order to increase the independent investigator workforce in research areas supported by the NIH HEAL Initiative®. This program is designed to facilitate a timely transition of eligible postdoctoral researchers from their mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition to help awardees establish independent research programs in areas supported by the NIH HEAL Initiative®.

This Funding Opportunity Announcement is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as “prospective basic science studies involving human participants.” These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should be submitted under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Applicants not planning an independent clinical trial or basic experimental study with humans, or proposing to gain research experience in a clinical trial or basic experimental study with humans led by another investigator, must apply to the 'Independent Clinical Trial Not Allowed' companion FOA.

The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.
RFA-DA-23-059 HEAL Initiative: Sleep Predictors of Opioid-Use Disorder Treatment Outcomes Program (R01 Clinical Trial Optional) New Strategies to Prevent and Treat Opioid Addiction Tue, 01/10/2023 Sat, 02/11/2023 Tue, 11/15/2022
no summary
RFA-DA-23-060 HEAL Initiative - Sleep Predictors of Opioid-Use Disorder Treatment Outcomes Program: Leadership and Data Co-ordinating Center (U01 Clinical Trial Optional) New Strategies to Prevent and Treat Opioid Addiction Tue, 01/10/2023 Sat, 02/11/2023 Tue, 11/15/2022
no summary
RFA-NS-22-069 HEAL Initiative Integrated Basic and Clinical Team-based Research in Pain (RM1 Clinical Trial Optional) Clinical Research in Pain Management, Preclinical and Translational Research in Pain Management Sat, 01/14/2023 Tue, 03/12/2024 Fri, 11/04/2022
no summary
RFA-NS-22-069 HEAL Initiative Integrated Basic and Clinical Team-based Research in Pain (RM1 Clinical Trial Optional) Clinical Research in Pain Management, Preclinical and Translational Research in Pain Management Sat, 01/14/2023 Tue, 03/12/2024 Fri, 11/04/2022
no summary
NOT-DA-23-009 Notice of Special Interest (NOSI): HEAL Initiative: Grand Opportunity in Medications Development for Substance-Use Disorders Novel Therapeutic Options for Opioid Use Disorder and Overdose Thu, 10/27/2022 Tue, 09/02/2025 Thu, 09/29/2022
no summary
NOT-DA-23-010 Notice of Special Interest (NOSI): HEAL Initiative: Development of Medications to Prevent and Treat Opioid and/or Stimulant Use Disorders and Overdose Novel Therapeutic Options for Opioid Use Disorder and Overdose Thu, 10/27/2022 Tue, 09/02/2025 Wed, 09/28/2022
no summary
RFA-NS-23-006 HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 Clinical Trial Not Allowed) Cross-Cutting Research Sun, 12/04/2022 Sat, 04/05/2025 Thu, 09/15/2022
no summary
RFA-NS-23-007 HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed) Cross-Cutting Research Sun, 12/04/2022 Sat, 04/05/2025 Thu, 09/15/2022
no summary
PAR-22-202 Grand Opportunity in Medications Development for Substance-Use Disorders (U01 Clinical Trial Optional) Novel Therapeutic Options for Opioid Use Disorder and Overdose Sat, 09/03/2022 Tue, 09/02/2025 Thu, 09/01/2022
no summary
PAR-22-200 Development of Medications to Prevent and Treat Opioid and/or Stimulant Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional) Novel Therapeutic Options for Opioid Use Disorder and Overdose Sat, 09/03/2022 Tue, 09/02/2025 Thu, 09/01/2022
no summary
RFA-EB-22-002 HEAL Initiative: Translational Development of Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Fri, 10/14/2022 Wed, 06/18/2025 Tue, 08/23/2022
no summary
NOT-DA-23-005 Notice of Special Interest (NOSI): HEAL Initiative: Biospecimen Collection in Pregnancy Enhanced Outcomes for Infants and Children Exposed to Opioids Sun, 09/25/2022 Sun, 10/08/2023 Mon, 08/22/2022
no summary
RFA-DA-23-055 HEAL Initiative: Development and validation of virtual assessments to study children and caregivers in their natural environment (R01- Basic Experimental Studies with Humans Required) Enhanced Outcomes for Infants and Children Exposed to Opioids Sat, 01/07/2023 Wed, 02/08/2023 Thu, 08/18/2022
no summary
RFA-DA-23-050 HEAL Initiative: Development and validation of virtual assessments to study children and caregivers in their natural environment (R01- Clinical Trial Not Allowed) Enhanced Outcomes for Infants and Children Exposed to Opioids Fri, 08/26/2022 Sat, 02/04/2023 Thu, 08/18/2022
no summary
RFA-NS-22-070 HEAL Initiative: Development and Validation of Non-Rodent Mammalian Models of Pain (R01 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Tue, 10/04/2022 Thu, 03/07/2024 Tue, 08/09/2022
no summary
RFA-DA-23-053 HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional) Translation of Research to Practice for the Treatment of Opioid Addiction Fri, 10/14/2022 Thu, 03/21/2024 Wed, 08/03/2022
no summary
NOT-NS-23-002 Notice of Special Interest (NOSI): HEAL Initiative: Clinical Translation of Diagnostic and Therapeutic Devices via Blueprint MedTech Preclinical and Translational Research in Pain Management Tue, 10/18/2022 Fri, 06/21/2024 Wed, 08/03/2022
no summary
NOT-NS-23-002 Notice of Special Interest (NOSI): HEAL Initiative: Clinical Translation of Diagnostic and Therapeutic Devices via Blueprint MedTech Preclinical and Translational Research in Pain Management Tue, 10/18/2022 Fri, 06/21/2024 Wed, 08/03/2022
no summary
NOT-DA-23-008 Notice of Special Interest (NOSI) HEAL Initiative: Workforce Interventions to Improve Addiction Care Quality and Patient Outcomes Cross-Cutting Research Wed, 10/05/2022 Mon, 09/08/2025 Wed, 08/03/2022
no summary
NOT-DA-23-007 Notice of Special Interest (NOSI): HEAL Initiative: Opioid Use Disorder Care Pathways for Individuals with Histories of Exposure to Violence Translation of Research to Practice for the Treatment of Opioid Addiction Wed, 10/12/2022 Sun, 07/13/2025 Wed, 08/03/2022
no summary
RFA-DE-23-015 HEAL Initiative: Oral Complications Arising from Pharmacotherapies to Treat Opioid Use Disorders (R01 Clinical Trial Not Allowed) Novel Therapeutic Options for Opioid Use Disorder and Overdose Fri, 12/16/2022 Wed, 02/15/2023 Wed, 08/03/2022
no summary
RFA-DE-23-016 HEAL Initiative: Oral Complications Arising from Pharmacotherapies to Treat Opioid Use Disorders (R21 Clinical Trial Not Allowed) Novel Therapeutic Options for Opioid Use Disorder and Overdose Fri, 12/16/2022 Wed, 02/15/2023 Wed, 08/03/2022
no summary
RFA-DA-23-054 HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R33 Clinical Trial Optional) Cross-Cutting Research Fri, 10/14/2022 Thu, 03/21/2024 Wed, 08/03/2022
no summary
RFA-NS-23-003 HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional) Preclinical and Translational Research in Pain Management Sat, 09/10/2022 Tue, 06/10/2025 Mon, 08/01/2022
no summary
NOT-NS-23-009 Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative Integrated Basic and Clinical Team-based Research in Pain (RM1 Clinical Trial Optional) Preclinical and Translational Research in Pain Management Fri, 11/11/2022 Sat, 07/01/2023 Fri, 07/29/2022
no summary
NOT-NS-22-095 HEAL Initiative Notice of Special Interest (NOSI): Development and Validation of Pain-Related Models and Endpoints to Facilitate Non-Addictive Analgesic Discovery Clinical Research in Pain Management Tue, 10/18/2022 Wed, 06/25/2025 Thu, 07/14/2022
no summary
PAS-22-207 HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K23 - Clinical Trial Required) Cross-Cutting Research Mon, 09/12/2022 Thu, 11/13/2025 Thu, 07/14/2022
no summary
NOT-DA-23-011 Notice of Special Interest (NOSI): HEAL Initiative: Regarding the Availability of Administrative Supplements to Support the Addition of Justice Measures Translation of Research to Practice for the Treatment of Opioid Addiction Mon, 08/01/2022 Tue, 05/16/2023 Thu, 07/14/2022
no summary
PAS-22-206 HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K01 - Clinical Trial Required) Cross-Cutting Research Mon, 09/12/2022 Thu, 11/13/2025 Thu, 07/14/2022
no summary
RFA-DA-23-046 HEAL Initiative: Research to Foster an Opioid Use Disorder Treatment System Patients Can Count On (RM1 - Clinical Trial Optional) Translation of Research to Practice for the Treatment of Opioid Addiction Mon, 01/02/2023 Fri, 02/03/2023 Wed, 07/06/2022
no summary
NOT-NS-22-087 Encourage Eligible NIH HEAL Initiative Awardees to Apply for Administrative Supplements to Support Career Enhancement Related to Clinical Research on Pain Clinical Research in Pain Management Mon, 06/20/2022 Fri, 02/16/2024 Mon, 06/06/2022
no summary
OTA-20-008 HEAL Initiative: EPPIC-Net Pain Research - Application for Clinical Trial and Related Activities (OT2) [ROLLING SUBMISSION ACCEPTED: THIS CLOSED DATE WILL BE ON THE EPPIC NET WEBPAGE] Clinical Research in Pain Management Fri, 06/03/2022 Wed, 07/31/2030 Fri, 06/03/2022
no summary
OTA-20-002 HEAL Initiative: EPPIC-Net Pain Research Asset Application – Dossier (OT1) [ROLLING SUBMISSION ACCEPTED: THIS CLOSED DATE WILL BE ON THE EPPIC NET WEBPAGE] Clinical Research in Pain Management Fri, 06/03/2022 Wed, 07/31/2030 Fri, 06/03/2022
no summary
NOT-NS-22-049 Notice of Early Termination of RFA-NS-21-015 "HEAL Initiative: Team Research for Initial Translational Efforts in Non-addictive Analgesic Therapeutics Development (U19 Clinical Trial Not Allowed)" Preclinical and Translational Research in Pain Management Sat, 03/27/2021 Wed, 10/11/2023 Fri, 04/22/2022
no summary
RFA-NS-22-052 HEAL Initiative: Team Research for Initial Translational Efforts in Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] (U19 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Mon, 05/09/2022 Wed, 10/11/2023 Fri, 04/22/2022
no summary
NOT-DA-22-056 Notice of Special Interest (NOSI): Developing Digital Therapeutics for Substance Use Disorders Novel Therapeutic Options for Opioid Use Disorder and Overdose Wed, 04/06/2022 Thu, 12/07/2023 Fri, 02/18/2022
no summary
RFA-NS-22-050 HEAL Initiative: Discovery of Biomarkers and Biomarker Signatures to Facilitate Clinical Trials for Pain Therapeutics (UG3/UH3 Clinical Trial Optional) Preclinical and Translational Research in Pain Management Fri, 02/11/2022 Fri, 02/24/2023 Tue, 02/08/2022
no summary
NOT-DA-22-001 Notice of Change to Key Dates for NIDA PAR-21-183, Developing Digital Therapeutics for Substance Use Disorders (UG3/UH3 Clinical Trial optional) Novel Therapeutic Options for Opioid Use Disorder and Overdose Sun, 07/04/2021 Thu, 12/07/2023 Sun, 02/06/2022
no summary
RFA-NS-22-018 HEAL Initiative: Discovery and Functional Evaluation of Human Pain-associated Genes and Cells (U19 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Thu, 02/17/2022 Fri, 03/10/2023 Fri, 02/04/2022
no summary
PAR-22-058 Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed) Preclinical and Translational Research in Pain Management, Cross-Cutting Research Tue, 02/15/2022 Tue, 05/02/2023 Fri, 01/21/2022
no summary
PAR-22-058 Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed) Preclinical and Translational Research in Pain Management, Cross-Cutting Research Tue, 02/15/2022 Tue, 05/02/2023 Fri, 01/21/2022
no summary
RFA-TR-22-013 Emergency Awards: HEAL Initiative – New Innovator Award (DP2 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Fri, 01/28/2022 Tue, 05/23/2023 Thu, 01/20/2022
no summary
NOT-TR-22-015 Notice of Early Termination of PAR-22-057 "Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed)" Cross-Cutting Research Tue, 02/15/2022 Tue, 05/02/2023 Thu, 01/20/2022
no summary
RFA-TR-22-011 Emergency Awards: HEAL Initiative-Early-Stage Discovery of New Pain and Opioid Use Disorder Targets Within the Understudied Druggable Proteome (R21 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Fri, 01/28/2022 Tue, 05/23/2023 Thu, 01/20/2022
no summary
RFA-NS-22-034 HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Wed, 02/02/2022 Sat, 12/07/2024 Fri, 01/07/2022
no summary
RFA-NS-21-029 HEAL Initiative: Planning Studies for Initial Analgesic Development [Small Molecules and Biologics] (R61 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Sat, 06/19/2021 Wed, 10/11/2023 Tue, 06/08/2021
no summary
NOT-NS-21-061 Notice of Early Termination of RFA-NS-21-016, HEAL Initiative: Planning Studies for Initial Analgesic Development Initial Translational Efforts [Small Molecules and Biologics] (R34 Clinical Trial Not Allowed) Preclinical and Translational Research in Pain Management Sat, 06/19/2021 Wed, 10/11/2023 Tue, 05/18/2021
no summary
PAR-21-183 Developing Digital Therapeutics for Substance Use Disorders (UG3/UH3 Clinical Trial optional) Novel Therapeutic Options for Opioid Use Disorder and Overdose Sun, 07/04/2021 Thu, 12/07/2023 Tue, 03/23/2021
no summary
OTA-21-005 HEAL Initiative: EPPIC-Net Pain Research Asset Application (OT1) Clinical Research in Pain Management Fri, 12/17/2021 Tue, 09/03/2024 Thu, 02/25/2021
no summary
NOT-NS-20-107
Notice of Special Interest to Encourage Eligible NIH HEAL Initiative Awardees to Apply for PA-20-222: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed) Cross-Cutting Research Sun, 11/15/2020 Thu, 05/16/2024 Mon, 10/19/2020

Diversity Supplement Guidance pdf  221.15 KB
RFA-NS-21-010 HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional) Preclinical and Translational Research in Pain Management Sun, 10/18/2020 Mon, 01/08/2024 Wed, 09/16/2020
no summary