Expanded treatment options for opioid use disorder (OUD) are needed to promote long-term recovery in more patients. The Helping to End Addiction Long-termSM Initiative, or NIH HEAL InitiativeSM, will accelerate the development of novel medications and devices to treat all aspects of the opioid addiction cycle, including progression to chronic use, withdrawal symptoms, craving, relapse, and overdose.

Research Programs

To comprehensively address opioid addiction, the NIH HEAL Initiative will support the development of new formulations of existing medications to treat OUD; longer-duration formulations to counteract opioid overdose; interventions for respiratory depression; and novel medications to treat progression to chronic use, withdrawal, craving, and relapse.

The NIH HEAL Initiative will support the creation of a coordinated, multidisciplinary consortium to develop anti-opioid vaccines and test them in clinical trials. These vaccines will induce antibodies that bind specifically to target opioids, reducing their effects and offering protection from overdose.

Funded Projects

2019
1-Year Sustained Release Naltrexone Implant for the prevention of relapse to opioid dependence
Sep 25, 2019
2019
A Long-Acting Bioabsorbable Naltrexone Subcutaneous Implant for Opioid Use Disorder
Sep 25, 2019
2019
A novel opioid receptor antagonist for treating abuse and overdose
Sep 25, 2019
2019
A novel therapeutic to ameliorate chronic pain and reduce opiate use
Sep 25, 2019
2019
PHASE 1A/1B CLINICAL TRIALS OF MULTIVALENT OPIOID VACCINE COMPONENTS
Nov 19, 2019

Open Funding Opportunities

2019
Development of Medications to Prevent and Treat Opioid Use Disorders and Overdose (UG3/UH3) (Clinical Trial Optional)
Sep 25, 2019

Closed Funding Opportunities

2019
Behavioral & Integrative Treatment Development Program (R01 Clinical Trial Optional)
Sep 25, 2019
2019
NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
Sep 25, 2019
2019
NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)
Sep 25, 2019
2019
NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
Sep 25, 2019
2019
Strategic Alliances for Medications Development to Treat Substance Use Disorders (R01 Clinical Trial Optional)
Sep 25, 2019