Expanded treatment options for opioid use disorder (OUD) are needed to promote long-term recovery in more patients. The Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, will accelerate the development of novel medications and devices to treat all aspects of the opioid addiction cycle, including progression to chronic use, withdrawal symptoms, craving, relapse, and overdose.

Research Programs

To comprehensively address opioid addiction, the NIH HEAL Initiative will support the development of new formulations of existing medications to treat OUD; longer-duration formulations to counteract opioid overdose; interventions for respiratory depression; and novel medications to treat progression to chronic use, withdrawal, craving, and relapse.

The NIH HEAL Initiative will support the creation of a coordinated, multidisciplinary consortium to develop anti-opioid vaccines and test them in clinical trials. These vaccines will induce antibodies that bind specifically to target opioids, reducing their effects and offering protection from overdose.

Funded Projects

2021
Development of cannabinoid-opioid combination with opioid sparing and synergistic analgesic effects to prevent opioid use disorder and overdose
Oct 12, 2021
2021
Non-invasive vagal nerve stimulation in opioid use disorders
Sep 25, 2021
2021
Development of Lofexidine as a First-line Non-Opioid Pharmacologic Treatment for Neonatal Opioid Withdrawal Syndrome
Sep 20, 2021
2021
Combating opioid addiction using CVL-936, a novel D3/D2 receptor antagonist
Sep 20, 2021
2021
An Intranasal GDNF Gene Therapy for Opioid Relapse Reduction
Sep 20, 2021

Open Funding Opportunities

2020
Development of Medications to Prevent and Treat Opioid Use Disorders and Overdose (UG3/UH3) (Clinical Trial Optional)
Jan 24, 2020

Closed Funding Opportunities

2019
NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
Sep 25, 2019
2019
Strategic Alliances for Medications Development to Treat Substance Use Disorders (R01 Clinical Trial Optional)
Sep 25, 2019
2019
NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)
Sep 25, 2019
2019
NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
Sep 25, 2019
2019
Prescription Drug Abuse (R01 Clinical Trial Optional)
Sep 25, 2019