Closed Funding Opportunities

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NOFO #	NOFO Title	Research Focus Area	Research Program
RFA-DA-13-009	Translational Research on Interventions for Adolescents in the Legal System: TRIALS (U01)	Translation of Research to Practice for the Treatment of Opioid Addiction	Justice Community Overdose Innovation Network (JCOIN)
no summary
RFA-DA-15-008	The National Drug Abuse Treatment Clinical Trials Network (UG1)	Translation of Research to Practice for the Treatment of Opioid Addiction	Enhancing the National Drug Abuse Treatment Clinical Trials Network to Address Opioids
no summary
PA-16-302	PHS 2016-02 Omnibus Solicitation of the NIH, CDC, FDA, and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])	New Strategies to Prevent and Treat Opioid Addiction	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
RFA-AT-18-001	Behavioral Interventions for Prevention of Opioid Use Disorder or Adjunct to Medication Assisted Treatment-SAMHSA Opioid STR Grants (R21/R33)	New Strategies to Prevent and Treat Opioid Addiction	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
RFA-DA-18-010	Wearable to Track Recovery and Relapse Factors for People w/ Addiction (R43/R44)	New Strategies to Prevent and Treat Opioid Addiction	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
RFA-DA-18-012	Development of a Device to Objectively Measure Pain (R43/R44)	New Strategies to Prevent and Treat Opioid Addiction	Translating Discoveries into Effective Devices to Treat Pain
no summary
PA-17-302	PHS 2017-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])	New Strategies to Prevent and Treat Opioid Addiction	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
RFA-AT-18-002	Clinical Trials or Observational Studies of Behavioral Interventions for Prevention of Opioid Use Disorder or Adjunct to Medication Assisted Treatment-SAMHSA Opioid STR Grants (R21/R33)	New Strategies to Prevent and Treat Opioid Addiction	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
PA-16-190	Mentored Research Scientist Development Award (Parent K01)	New Strategies to Prevent and Treat Opioid Addiction	Preventing Opioid Use Disorder
no summary
RFA-DA-19-017	HEALing Communities Study: Developing and Testing an Integrated Approach to Address the Opioid Crisis (Data Coordinating Center) (UM1- Clinical Trials Not Allowed)	Translation of Research to Practice for the Treatment of Opioid Addiction	HEALing Communities Study
no summary
RFA-DA-19-016	HEALing Communities Study: Developing and Testing an Integrated Approach to Address the Opioid Crisis (Research Sites) (UM1 - Clinical Trial Required)	Translation of Research to Practice for the Treatment of Opioid Addiction	HEALing Communities Study
no summary
RFA-DA-19-008	The National Drug Abuse Treatment Clinical Trials Network (UG1 Clinical Trial Optional)	Translation of Research to Practice for the Treatment of Opioid Addiction	Enhancing the National Drug Abuse Treatment Clinical Trials Network to Address Opioids
no summary
PA-18-055	Behavioral & Integrative Treatment Development Program (R01 Clinical Trial Optional)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
no summary
PA-18-489	NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
no summary
PA-18-344	NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
no summary
PA-18-484	NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
no summary
PA-18-345	NIH Research Project Grant (Parent R01 Clinical Trial Required)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
no summary
NOT-DA-19-003	HEAL Initiative: Request for Administrative Supplements to Existing Grants to Accelerate Research on Preventing Opioid Use Disorder in Older Adolescents and Young Adults (ages 16-30)	New Strategies to Prevent and Treat Opioid Addiction	Preventing Opioid Use Disorder
no summary
RFA-DA-19-024	HEAL Initiative: Justice Community Opioid Innovation Network (JCOIN) Coordination and Translation Center (U2C Clinical Trial Optional)	Translation of Research to Practice for the Treatment of Opioid Addiction	Justice Community Overdose Innovation Network (JCOIN)
no summary
RFA-DA-19-023	HEAL Initiative: Justice Community Opioid Innovation Network (JCOIN) Methodology and Advanced Analytics Resource Center (U2C Clinical Trial Not Allowed)	Translation of Research to Practice for the Treatment of Opioid Addiction	Justice Community Overdose Innovation Network (JCOIN)
no summary
PA-18-573	PHS 2018-02 Omnibus Solicitation of the NIH for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)	New Strategies to Prevent and Treat Opioid Addiction	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
PA-18-575	PHS 2018-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)	New Strategies to Prevent and Treat Opioid Addiction	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
PA-18-574	PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)	New Strategies to Prevent and Treat Opioid Addiction	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
PA-18-574	PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)	New Strategies to Prevent and Treat Opioid Addiction	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
PA-18-058	Prescription Drug Abuse (R01 Clinical Trial Optional)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
no summary
NOT-TR-18-031	HEAL Initiative: Announcement of the NCATS ASPIRE Design Challenges to Develop Innovative and Catalytic Approaches Towards Solving the Opioid Crisis	Preclinical and Translational Research in Pain Management	Translational Research to Advance Testing of Novel Drugs and Human Cell-Based Screening Platforms to Treat Pain and Opioid Use Disorder
no summary
RFA-NS-19-036	HEAL Initiative: Early Phase Pain Investigation Clinical Network - Specialized Clinical Centers (U24 Clinical Trial Not Allowed)	Clinical Research in Pain Management	Early Phase Pain Investigation Clinical Network (EPPIC-Net)
no summary
RFA-NS-19-020	HEAL Initiative: Optimization of Non-addictive Therapies [Small Molecules and Biologics] to Treat Pain - (U44 Clinical Trial Not Allowed)	Preclinical and Translational Research in Pain Management	Development and Optimization of Non-Addictive Therapies to Treat Pain
no summary
RFA-NS-19-010	Optimization of Non-addictive Therapies [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Not Allowed)	Preclinical and Translational Research in Pain Management	Development and Optimization of Non-Addictive Therapies to Treat Pain
no summary
PAR-18-219	Grand Opportunity in Medications Development for Substance-Use Disorders (U01 Clinical Trial Optional)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
no summary
PAR-18-218	Strategic Alliances for Medications Development to Treat Substance Use Disorders (R01 Clinical Trial Optional)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
NOT-NS-19-014	HEAL Initiative: Notice of Interest in Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Applications Directed at Enhanced Pain Management and Improved Treatments for Opioid Misuse and Addiction	Cross-Cutting Research	Small Business Programs
no summary
RFA-NS-18-046	Analytical and/or Clinical Validation of a Candidate Biomarker for Pain (R61/R33 Clinical Trial Optional)	Preclinical and Translational Research in Pain Management	Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions
no summary
RFA-NS-18-041	Discovery of Biomarkers, Biomarker Signatures, and Endpoints for Pain (R61/R33 Clinical Trial Optional)	Preclinical and Translational Research in Pain Management	Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions
no summary
NOT-AR-20-016	HEAL Initiative: Back Pain Consortium (BACPAC) Research Program Notice of Special Interest (NOSI) regarding the Availability of Urgent Competitive Revisions	Clinical Research in Pain Management	Back Pain Consortium Research Program
no summary
RFA-NS-20-028	HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)	Clinical Research in Pain Management	Pain Management Effectiveness Research Network (ERN)
no summary
RFA-HL-20-031	HEAL Initiative: Pharmacotherapies to Reverse Opioid Overdose Induced Respiratory Depression without Central Opioid Withdrawal (Target Validation and Candidate Therapeutic Development (R61/R33 - Clinical Trial Not Allowed)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
no summary
RFA-AT-20-004	HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional)	Clinical Research in Pain Management	Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM)
no summary
NOT-MH-20-025	Notice of Special Interest: HEAL Supplements to Improve the Treatment and Management of Common Co-occurring Conditions and Suicide Risk in People Affected by the Opioid Crisis	New Strategies to Prevent and Treat Opioid Addiction	Optimizing Care for People with Opioid Use Disorder and Mental Health Conditions
no summary
NOT-DA-20-033	Notice of Special Interest(NOSI): HEAL Initiative: Social Network Analyses to Reduce American Indian and Alaska Native Opioid Use Disorder and Related Risks for Suicide and Mental Health Disorders	New Strategies to Prevent and Treat Opioid Addiction	Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain
no summary
PAR-18-541	Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)	Preclinical and Translational Research in Pain Management	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
NOT-OD-20-101	HEAL Initiative: Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements to Support Strategies to Reduce Stigma in Pain Management and Opioid Use Disorder (OUD) and Treatment	Cross-Cutting Research	Stigma in Pain Management and Opioid Use Disorder
no summary
NOT-HL-20-746	Notice of Special Interest (NOSI): NHLBI and NIDA Announce Availability of Administrative Supplements for HEAL Awardees to Address Sleep Impairments in OUD Treatment Response and Recovery Outcomes		Sleep Dysfunction as a Core Feature of Opioid Use Disorder and Recovery
no summary
NOT-TR-20-008	Notice of Special Interest for HEAL Initiative: Request for Administrative Supplements to Existing Grants for Identification and Validation of New Pain and Opioid Use Disorder Targets within the Understudied Druggable Genome	Preclinical and Translational Research in Pain Management	Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain
no summary
NOT-NS-20-023	Notice of Special Interest to Encourage Eligible NIH HEAL Initiative Awardees to Apply for PA-18-906 Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)	Cross-Cutting Research	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
NOT-NS-20-044	Notice of Special Interest to Encourage Eligible NIH HEAL Initiative Awardees to Apply for Administrative Supplements to Promote Training in Clinical Research on Pain (Admin Supp – Clinical Trial Not Allowed)	Clinical Research in Pain Management	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
PAR-20-092	Development of Medications to Prevent and Treat Opioid Use Disorders and Overdose (UG3/UH3) (Clinical Trial Optional)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
no summary
RFA-DA-18-020	NIDA Translational Avant-Garde Award for Development of Medication to Treat Substance Use Disorders (UG3/UH3 Clinical Trial Optional)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
RFA-NS-19-018	HEAL Initiative: Clinical Devices to Treat Pain (UH3 Clinical Trial Optional)	Preclinical and Translational Research in Pain Management	Translating Discoveries into Effective Devices to Treat Pain
no summary
RFA-EB-18-003	HEAL Initiative: Translational Development of Devices to Treat Pain (U18 Clinical Trial Not Allowed)	Preclinical and Translational Research in Pain Management	Translating Discoveries into Effective Devices to Treat Pain
no summary
RFA-NS-19-017	HEAL Initiative: Translational Devices to Treat Pain (U44 Clinical Trial Optional)	Preclinical and Translational Research in Pain Management	Translating Discoveries into Effective Devices to Treat Pain
no summary
RFA-NS-19-016	HEAL Initiative: Translational Devices to Treat Pain (UG3/UH3 Clinical Trial Optional)	Preclinical and Translational Research in Pain Management	Translating Discoveries into Effective Devices to Treat Pain
no summary
NCATS ASPIRE	2020 NCATS ASPIRE Reduction-to-Practice Challenge	Preclinical and Translational Research in Pain Management	Translational Research to Advance Testing of Novel Drugs and Human Cell-Based Screening Platforms to Treat Pain and Opioid Use Disorder
no summary
RFA-MH-21-145	HEAL Initiative: Optimizing Multi-Component Service Delivery Interventions for People with Opioid Use Disorder, Co-Occurring Conditions, and/or Suicide Risk (R01 Clinical Trials Optional)	New Strategies to Prevent and Treat Opioid Addiction	Optimizing Care for People with Opioid Use Disorder and Mental Health Conditions
no summary
RFA-DA-21-029	HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Coordination and Dissemination Center (R24 Clinical Trial Optional)	Clinical Research in Pain Management	Reducing Opioid-Related Harms to Treat Chronic Pain (IMPOWR and MIRHIQL)
no summary
RFA-DA-21-030	HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)	Clinical Research in Pain Management	Reducing Opioid-Related Harms to Treat Chronic Pain (IMPOWR and MIRHIQL)
no summary
RFA-HD-21-032	HEAL Initiative: Data Coordinating Center for the Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial (U24 Clinical Trial Required)	Enhanced Outcomes for Infants and Children Exposed to Opioids	Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW)
no summary
RFA-HD-21-031	HEAL Initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial - Clinical Sites (UG1 Clinical Trial Required)	Enhanced Outcomes for Infants and Children Exposed to Opioids	Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW)
no summary
RFA-DA-21-022	HEAL Initiative: HEALthy Brain and Child Development Consortium Administrative Core (U24 - Clinical Trial Not Allowed)	Enhanced Outcomes for Infants and Children Exposed to Opioids	HEALthy Brain and Child Development (HBCD) Study
no summary
RFA-DA-21-023	HEAL Initiative: HEALthy Brain and Child Development Data Coordinating Center (U24)	Enhanced Outcomes for Infants and Children Exposed to Opioids	HEALthy Brain and Child Development (HBCD) Study
no summary
RFA-DA-21-020	HEAL Initiative: HEALthy Brain and Child Development Study (Collaborative U01- Clinical Trial Not Allowed)	Enhanced Outcomes for Infants and Children Exposed to Opioids	HEALthy Brain and Child Development (HBCD) Study
no summary
RFA-DA-21-021	HEAL Initiative: HEALthy Brain and Child Development Study (U01 - Clinical Trial Not Allowed)	Enhanced Outcomes for Infants and Children Exposed to Opioids	HEALthy Brain and Child Development (HBCD) Study
no summary
NOT-NS-21-025	HEAL Initiative: Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements to Support Strategies to Increase Participant Diversity, Inclusion and Engagement in Clinical Studies	Cross-Cutting Research	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
RFA-NS-21-016	Planning Studies for Initial Analgesic Development Initial Translational Efforts [Small Molecules and Biologics] (R34 Clinical Trial Not Allowed)	Preclinical and Translational Research in Pain Management	Development and Optimization of Non-Addictive Therapies to Treat Pain
no summary
NOT-NS-21-026	HEAL Initiative: Notice of Special Interest (NOSI): Limited Competition to Support Mentorship of Junior Investigators	Cross-Cutting Research	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
RFA-DA-19-020	HEAL Initiative: America’s Startups and Small Businesses Build Technologies to Stop the Opioid Crisis (R41/R42 - Clinical Trial Optional)		Small Business Programs
no summary
RFA-DA-19-019	HEAL Initiative: America’s Startups and Small Businesses Build Technologies to Stop the Opioid Crisis (R43/R44 - Clinical Trial Optional)	New Strategies to Prevent and Treat Opioid Addiction	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
RFA-DA-22-031	HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R01 Clinical Trial Not Allowed)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
no summary
RFA-DA-22-032	HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R21 Clinical Trial Not Allowed)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
no summary
NOT-DA-21-066	Notice of Correction to RFA-DA-22-031, HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R01 Clinical Trial Not Allowed)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
no summary
NOT-DA-21-067	Notice of Correction to RFA-DA-22-032, HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R21 Clinical Trial Not Allowed)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
no summary
RFA-NS-22-016	HEAL Initiative: Interdisciplinary Teams to Elucidate the Mechanisms of Device-Based Pain Relief (RM1 Clinical Trial Optional)	Preclinical and Translational Research in Pain Management	Translating Discoveries into Effective Devices to Treat Pain
no summary
RFA-HL-22-013	HEAL initiative: Pharmacotherapies to Reverse Opioid Overdose Induced Respiratory Depression Without Central Opioid Withdrawal (Target Validation and Candidate Therapeutic Development) (UG3/UH3 Clinical Trials Not Allowed)	Novel Therapeutic Options for Opioid Use Disorder and Overdose	Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
no summary
RFA-NS-22-002	HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)		Advancing Health Equity in Pain Management
no summary
RFA-AT-22-004	HEAL Initiative: Pragmatic and Implementation Studies for the Management of Sickle Cell Disease Pain (UG3/UH3, Clinical Trials Optional)	Clinical Research in Pain Management	Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM)
no summary
RFA-AT-22-005	HEAL Initiative: Sickle Cell Disease Pain Management Trials Utilizing the Pain Management Effectiveness Research Network Cooperative Agreement (UG3/UH3, Clinical Trial Required)	Clinical Research in Pain Management	Pain Management Effectiveness Research Network (ERN)
no summary
NOT-NS-22-057	Notice of Information: Multi-Institute Interest in Pain Research [SUBMISSION AND EXPIRATION DATE ARE ESTIMATED]		Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
NOT-OD-22-033	Notice of Special Interest (NOSI): Availability of Administrative Supplements for Helping to End Addiction Long-term (HEAL) Initiative awardees to make data Findable, Accessible, Interoperable, and Reusable (FAIR) through the HEAL Data Ecosystem	Cross-Cutting Research	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
RFA-MH-22-175	Emergency Award HEAL Initiative: Optimizing Existing Evidence-Based Multi-Component Service Delivery Interventions for People with Opioid Use Disorder, Co-Occurring Conditions, and/or Suicide Risk (R01 Clinical Trials Optional)	New Strategies to Prevent and Treat Opioid Addiction	Optimizing the Duration, Retention, and Discontinuation of Medication Treatment for Opioid Use Disorder
no summary
RFA-AT-22-003	HEAL Initiative: Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management (R61/R33, Clinical Trial Required)	Clinical Research in Pain Management	Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions
no summary
NOT-AT-22-011	NCCIH Announces Availability of Frequently Asked Questions (FAQs) for RFA-AT-22-003: HEAL Initiative: Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management (R61/R33, Clinical Trial Required)	Clinical Research in Pain Management	Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions
no summary
RFA-DA-22-036	NIH HEAL Initiative: Preventing Opioid Misuse and Co-Occurring Conditions by Intervening on Social Determinants (R01 Clinical Trials Optional)	Clinical Research in Pain Management	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
RFA-DA-22-034	HEAL Initiative: Planning Grants for Efficacy or Effectiveness Trials of Recovery Support Services for Individuals Treated with Medications for Opioid Use Disorder (R34 Clinical Trial Optional)	Translation of Research to Practice for the Treatment of Opioid Addiction	Recovery Research Networks
no summary
RFA-DA-22-044	HEAL Initiative: Data and Methods to Address Urgent Needs to Stem the Opioid Epidemic (R01- Clinical Trial Not Allowed)	New Strategies to Prevent and Treat Opioid Addiction	Leveraging Existing and Real-Time Opioid and Pain Management Data
no summary
RFA-DA-22-045	HEAL Initiative: Exploratory Data and Methods to Address Urgent Needs to Stem the Opioid Epidemic (R21- Clinical Trial Not Allowed)	New Strategies to Prevent and Treat Opioid Addiction	Leveraging Existing and Real-Time Opioid and Pain Management Data
no summary
RFA-DA-22-046	HEAL Initiative: Harm Reduction Policies, Practices, and Modes of Delivery for Persons with Substance Use Disorders (R01 Clinical Trial Optional)	Translation of Research to Practice for the Treatment of Opioid Addiction	Harm Reduction Research Network
no summary
RFA-DA-22-042	HEAL Initiative: Harm Reduction Policies, Practices, and Modes of Delivery for Persons with Substance Use Disorders: Coordination Center (R24 Clinical Trial Optional)	Translation of Research to Practice for the Treatment of Opioid Addiction	Harm Reduction Research Network
no summary
RFA-DA-22-052	HEAL Initiative: HEAL Data2Action (HD2A) Data Infrastructure Support Center (U24 Clinical Trial Optional)	Translation of Research to Practice for the Treatment of Opioid Addiction	HEAL Data2Action (HD2A)
no summary
RFA-DA-22-051	HEAL Initiative: HEAL Data2Action Innovation Projects (R61/R33 Clinical Trial Optional)	Translation of Research to Practice for the Treatment of Opioid Addiction	HEAL Data2Action (HD2A)
no summary
RFA-DA-22-049	HEAL Initiative: HEAL Data2Action Modeling and Economic Resource Center (U24 Clinical Trial Optional)	Translation of Research to Practice for the Treatment of Opioid Addiction	HEAL Data2Action (HD2A)
no summary
NOT-AA-22-009	HEAL Initiative: Pilot & Feasibility Trials to Improve Prevention and Treatment Service Delivery for Polysubstance Use (R34 Clinical Trial Optional)	Translation of Research to Practice for the Treatment of Opioid Addiction	Improving Delivery of Healthcare Services for Polysubstance Use
no summary
RFA-DA-22-048	HEAL Initiative: Pilot & Feasibility Trials to Improve Prevention and Treatment Service Delivery for Polysubstance Use (R34-Clinical Trial Optional)	Translation of Research to Practice for the Treatment of Opioid Addiction	Improving Delivery of Healthcare Services for Polysubstance Use
no summary
RFA-DA-22-043	HEAL Initiative: Research Networks for the Study of Recovery Support Services for Persons Treated with Medications for Opioid Use Disorder (R24 Clinical Trial Optional)	Translation of Research to Practice for the Treatment of Opioid Addiction	Recovery Research Networks
no summary
RFA-DA-22-047	HEAL Initiative: Understanding Polysubstance Use and Improving Service Delivery to Address Polysubstance Use (R01 Clinical Trial Optional)	Translation of Research to Practice for the Treatment of Opioid Addiction	Improving Delivery of Healthcare Services for Polysubstance Use
no summary
NOT-AA-22-008	HEAL Initiative: Understanding Polysubstance Use and Improving Service Delivery to Address Polysubstance Use (R01 Clinical Trial Optional)	Translation of Research to Practice for the Treatment of Opioid Addiction	Improving Delivery of Healthcare Services for Polysubstance Use
no summary
RFA-TR-22-012	Emergency Awards: HEAL Initiative-Limited Competition: HEAL Initiative Resource Centers for the Pain Management Effectiveness Research Network (ERN) (U24 Clinical Trial Not Allowed)	Clinical Research in Pain Management	Pain Management Effectiveness Research Network (ERN)
no summary
RFA-MH-22-175	Emergency Award HEAL Initiative: Optimizing Existing Evidence-Based Multi-Component Service Delivery Interventions for People with Opioid Use Disorder, Co-Occurring Conditions, and/or Suicide Risk (R01 Clinical Trials Optional)	New Strategies to Prevent and Treat Opioid Addiction	Optimizing Care for People with Opioid Use Disorder and Mental Health Conditions
no summary
RFA-NS-22-037	HEAL Initiative: Advancing Health Equity in Pain and Comorbidities (R61/R33 Clinical Trial Required)	Clinical Research in Pain Management	Advancing Health Equity in Pain Management
no summary
RFA-NS-22-046	HEAL Initiative: Coordinating Center for National Pain Scientists Career Development (R24 Clinical Trial Not Allowed)	Clinical Research in Pain Management	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
RFA-NS-22-045	HEAL Initiative: National K12 Clinical Pain Career Development Program (K12 Clinical Trial Not Allowed)	Clinical Research in Pain Management	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
RFA-DA-22-050	HEAL Initiative: HEAL Data2Action Research Adoption Support Center (U2C Clinical Trial Optional)	Translation of Research to Practice for the Treatment of Opioid Addiction	HEAL Data2Action (HD2A)
no summary
RFA-DE-22-011	HEAL Initiative: Secondary Analysis and Integration of Existing Data Related to Acute and Chronic Pain Development or Management in Humans (R21 Clinical Trials Not Allowed)	Clinical Research in Pain Management	Leveraging Existing and Real-Time Opioid and Pain Management Data
no summary
RFA-AR-22-009	HEAL Initiative: Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN) (UC2 Clinical Trial Not Allowed)	Preclinical and Translational Research in Pain Management	Restoring Joint Health and Function to Reduce Pain (RE-JOIN)
no summary
NOT-AR-22-016	Notice of Technical Assistance Webinar for RFA-AR-22-009, HEAL Initiative: Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN)	Preclinical and Translational Research in Pain Management	Restoring Joint Health and Function to Reduce Pain (RE-JOIN)
no summary
NOT-NS-22-066	HEAL Initiative: Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements to Support Strategies to Increase Participant Diversity, Inclusion and Engagement in Clinical Studies	Clinical Research in Pain Management	Advancing Health Equity in Pain Management
no summary
NOT-OD-22-110	Notice of Special Interest (NOSI): Availability of Administrative Supplements for Helping to End Addiction Long-term (HEAL) Initiative awardees to make data Findable, Accessible, Interoperable, and Reusable (FAIR) through the HEAL Data Ecosystem	Cross-Cutting Research	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
RFA-DA-23-041	HEAL Initiative: Multilevel Interventions to Reduce Harm and Improve Quality of Life for Patients on Long Term Opioid Therapy (MIRHIQL) (R01 Clinical Trial Required)		Reducing Opioid-Related Harms to Treat Chronic Pain (IMPOWR and MIRHIQL)
no summary
RFA-DA-23-042	HEAL Initiative: Multilevel Interventions to Reduce Harm and Improve Quality of Life for Patients on Long Term Opioid Therapy (MIRHIQL): Resource Center (U24- Clinical Trial Optional)		Reducing Opioid-Related Harms to Treat Chronic Pain (IMPOWR and MIRHIQL)
no summary
RFA-NS-20-008	HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Required)	Preclinical and Translational Research in Pain Management	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
PAR-22-058	Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed)	Preclinical and Translational Research in Pain Management, Cross-Cutting Research	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
no summary
PAR-22-058	Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed)	Preclinical and Translational Research in Pain Management, Cross-Cutting Research	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
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RFA-TR-22-013	Emergency Awards: HEAL Initiative – New Innovator Award (DP2 Clinical Trial Not Allowed)	Preclinical and Translational Research in Pain Management	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
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RFA-TR-22-011	Emergency Awards: HEAL Initiative-Early-Stage Discovery of New Pain and Opioid Use Disorder Targets Within the Understudied Druggable Proteome (R21 Clinical Trial Not Allowed)	Preclinical and Translational Research in Pain Management	Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain
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RFA-HD-24-011 Show Summary	HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain: Acute Pain Clinical Trials Program (U01 Clinical Trial Required)	Clinical Research in Pain Management	Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
Summary: As part of the NIH's Helping to End Addiction Long-term (HEAL) Initiative, the Eunice Kennedy Shriver National Institute of Child Health and Human Development and participating NIH Institutes and Centers invite applications to this U01 Cooperative Agreement funding opportunity to support innovative, multi-site, large-scale investigator-initiated clinical trials to advance the understanding, assessment, measurement, treatment, and prevention of acute pain in infants, children, and adolescents, including those with disabilities and/or experiencing health disparities. For more information, please see the technical assistance webinar and FAQ.
RFA-EB-22-002	HEAL Initiative: Translational Development of Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed)	Preclinical and Translational Research in Pain Management	Translating Discoveries into Effective Devices to Treat Pain
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RFA-NS-23-003	HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional)	Preclinical and Translational Research in Pain Management	Translating Discoveries into Effective Devices to Treat Pain
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OTA-20-008	HEAL Initiative: EPPIC-Net Pain Research - Application for Clinical Trial and Related Activities (OT2) [ROLLING SUBMISSION ACCEPTED: BY INVITATION ONLY]	Clinical Research in Pain Management	Early Phase Pain Investigation Clinical Network (EPPIC-Net)
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OTA-20-002	HEAL Initiative: EPPIC-Net Pain Research Asset Application – Dossier (OT1) [ROLLING SUBMISSION ACCEPTED: BY INVITATION ONLY]	Clinical Research in Pain Management	Early Phase Pain Investigation Clinical Network (EPPIC-Net)
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