The Helping to End Addiction Long-termSM Initiative, or NIH HEAL InitiativeSM, supports a wide range of programs to develop new or improved prevention and treatment strategies for opioid addiction. Program goals include:

  • Preventing individuals with low-severity opioid use disorder (OUD) from developing a more serious OUD
  • Building strategies to keep people in medication treatment for opioid addiction
  • Understanding the role of sleep dysfunction in OUD and recovery
  • Stopping at-risk adolescents from developing OUD
  • Exploring collaborative care for people with OUD and mental health conditions

Research Programs

Collaborative care has been shown to be effective for treating mood and anxiety disorders, but more research is needed to demonstrate its usefulness for OUD. Researchers will test the adaptation, effectiveness, adoption, scalability, and sustainability of collaborative care for individuals with OUD and co-occurring mental health conditions using integrated treatment models in primary care settings.

Older adolescents and young adults are at the highest risk for opioid initiation, misuse, OUD, and overdose fatality. A series of studies will develop and test strategies for preventing opioid misuse and addiction in at-risk older adolescents and young adults in a variety of health care settings. The studies will build on research models that have successfully addressed alcohol consumption in this population.

The NIH HEAL Initiative will support research using genomic, molecular, pharmacological, and clinical approaches to better understand sleep and circadian factors relevant to addiction and how these factors influence one another. This research could open new avenues for therapeutic strategies, OUD prevention, and treatment approaches.

The NIH HEAL Initiative will support research to define the optimal length of FDA-approved medication treatments for OUD, methadone and buprenorphine, taking into account various patient populations and treatment settings.

The Subthreshold Opioid Use Disorder Prevention (STOP) Study will help researchers better understand how to define, identify, and intervene in the management of opioid misuse among individuals with low-severity OUD in primary care settings.

Funded Projects

2020
A digital intervention to prevent the initiation of opioid misuse in adolescents in school-based health centers
Mar 19, 2020
2020
A SYSTEM OF SAFETY (SOS): PREVENTING SUICIDE THROUGH HEALTHCARE SYSTEM TRANSFORMATION
Mar 19, 2020
2020
Accelerator Strategies for States to Improve System Transformations Affecting Children Youth and Families
Mar 19, 2020
2020
AOD Use Trajectories from Age 10 to 24: Multi-level Predictors, Health and Behavioral Functioning, and Racial/ethnic Disparitie
Mar 19, 2020
2020
Virtual Reality as a Opioid Sparing Intervention for Acute Postoperative Pain Management
Mar 19, 2020

Open Funding Opportunities

2019
HEAL Initiative: America’s Startups and Small Businesses Build Technologies to Stop the Opioid Crisis (R43/R44 - Clinical Trial Optional)
Sep 25, 2019

Closed Funding Opportunities

2019
PHS 2018-02 Omnibus Solicitation of the NIH for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)
Sep 25, 2019
2019
PHS 2018-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
Sep 25, 2019
2019
PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
Sep 25, 2019
2019
PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
Sep 25, 2019
2019
PHS 2016-02 Omnibus Solicitation of the NIH, CDC, FDA, and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
Sep 25, 2019