Overview

The Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, supports a wide range of programs to develop new or improved prevention and treatment strategies for opioid addiction and co-occurring conditions such as mental illness and polysubstance use. Programs are developing and implementing prevention and treatment strategies for a range of at-risk populations and in various settings. This research is also developing strategies to understand and monitor biological and social factors that drive disease progression, as well as defining approaches to improve treatment retention.

Open Funding Opportunities

2022
HEAL Initiative: Preventing Opioid Misuse and Co-Occurring Conditions by Intervening on Social Determinants (R01 - Clinical Trials Optional)
Jul 13, 2022

Research Programs

Research shows that collaborative care is effective for treating mood and anxiety disorders, but more research is needed to demonstrate its usefulness for treating opioid use disorder. The Optimizing Care for People with Opioid Use Disorder and Mental Health Conditions program tests the adaptation, effectiveness, adoption, scalability, and sustainability of collaborative care for individuals with opioid use disorder and co-occurring mental health conditions using integrated treatment models in primary care settings.

The Preventing Opioid Use Disorder program supports prevention research focused on underserved populations that experience health disparities and centered around four strategic areas: identifying risk, studying the role of social determinants and policy, developing effective interventions, and disseminating and implementing sustainable, scalable prevention services for populations with risk for opioid misuse.

The Sleep Dysfunction as a Core Feature of Opioid Use Disorder and Recovery program supports research using genomic, molecular, pharmacological, and clinical approaches to better understand sleep and circadian factors relevant to addiction and how these factors influence one another. This research could open new avenues for prevention and treatment of opioid use disorder.

The Optimizing the Duration, Retention, and Discontinuation of Medication Treatment for Opioid Use Disorder program supports research to define the optimal length of medication treatments approved by the U.S. Food and Drug Administration for opioid use disorder (methadone and buprenorphine), taking into account various patient populations and treatment settings.

The Subthreshold Opioid Use Disorder Prevention (STOP) Study aims to help researchers better understand how to define, identify, and intervene in the management of opioid misuse in primary care settings among individuals with low-severity opioid use disorder.

This program will design and test a primary care setting-based, multidisciplinary treatment model to serve patients with unhealthy use of opioids and alcohol, stimulants, and/or sedatives. Researchers will first plan, develop, and define a treatment model and pilot test its feasibility and acceptability.

The Randomized, Double-Blind, Placebo-Controlled Trial of Monthly Injectable Buprenorphine for Methamphetamine Use Disorder (MURB) will help researchers determine whether monthly injections of buprenorphine are safe and effective in people with methamphetamine use disorder who also misuse opioids at levels that do not warrant medication-based treatment.

Funded Projects

2022
Disrupting Social Determinants of Health to Improve Substance Use and Mental Health Outcomes for Parents in Rural Regions
Sep 19, 2022
2021
Optimized Interventions to Prevent Opioid Use Disorder among Adolescents and Young Adults in the Emergency Department
Sep 25, 2021
2021
The Role of Family Functioning and Race/Ethnicity on the Efficacy of an Opioid Misuse Prevention Videogame Intervention for Adolescents
Sep 25, 2021
2021
Preventing Substance Misuse and Substance Use Disorder by Examining Service Provider Interactions, Discrimination, Ethnic Identity, Sexual Orientation Identity, and Housing First Outcomes
Sep 25, 2021
2021
Supporting Treatment Access and Recovery for Co-Occurring Opioid Use and Mental Health Disorders (STAR-COD)
Sep 20, 2021

Closed Funding Opportunities

2021
HEAL Initiative: Data and Methods to Address Urgent Needs to Stem the Opioid Epidemic (R01- Clinical Trial Not Allowed)
Dec 20, 2021
2021
HEAL Initiative: Exploratory Data and Methods to Address Urgent Needs to Stem the Opioid Epidemic (R21- Clinical Trial Not Allowed)
Dec 20, 2021
2020
Notice of Special Interest(NOSI): HEAL Initiative: Social Network Analyses to Reduce American Indian and Alaska Native Opioid Use Disorder and Related Risks for Suicide and Mental Health Disorders
Feb 06, 2020
2020
Notice of Special Interest: HEAL Supplements to Improve the Treatment and Management of Common Co-occurring Conditions and Suicide Risk in People Affected by the Opioid Crisis
Feb 05, 2020
2019
PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
Sep 25, 2019