Overview

There are multiple effective evidence-based treatments and programs for opioid use disorder. Most Americans at risk for or who have this condition, however, do not receive treatment. At the same time, opioid overdoses are increasingly deadly across the nation. To better understand how promising, evidence-based strategies and treatments might help more people with opioid use disorder, the Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, supports implementation research to test the integration of evidence-based interventions in various community settings.

Open Funding Opportunities

2022
HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)
Aug 03, 2022
2022
Notice of Special Interest (NOSI): HEAL Initiative: Opioid Use Disorder Care Pathways for Individuals with Histories of Exposure to Violence
Aug 03, 2022

Research Programs

In collaboration with the Substance Abuse and Mental Health Services Administration, the Behavioral Research to Improve Medication-Based Treatment program is studying whether combining behavioral interventions with medication-based treatment for opioid use disorder improves health outcomes for patients with the condition. Behavioral interventions such as mindfulness meditation, cognitive behavioral therapy, and multidisciplinary rehabilitation are being evaluated as ways to increase adherence to medication-based treatment, reduce relapse, and improve health outcomes.

The Continuum of Care in Hospitalized Patients with Opioid Use Disorder and Infectious Complications of Drug Use (CHOICE) program will evaluate patients hospitalized with an infectious complication of injection drug use and identify and understand gaps in care that arise across the continuum of care. The program will develop an informed intervention to eliminate barriers and improve health outcomes in this population.

Expansion of the National Drug Abuse Treatment Clinical Trials Network (CTN) is addressing emergent needs presented by the nation’s opioid and overdose crisis. The CTN integrates new opioid-related research questions into clinical studies related to substance use that are currently underway, expedites new studies in general medical and other settings, and enhances clinical and research training opportunities.

In support of the Administration’s focus on harm reduction to prevent or reduce overdose deaths, the Harm Reduction Approaches to Reduce Overdose Deaths program will establish a harm reduction network of research projects. This research will evaluate the effectiveness, implementation, and impact of existing and new harm reduction approaches.

The HEALing Communities Study partners with a diverse set of communities hit hard by the opioid crisis to test the integration of evidence-based strategies for prevention, medication-based treatment, and overdose reversal. This comprehensive treatment model will be tested in a coordinated array of settings, including primary care, emergency departments, and other community settings. The findings will establish best practices for integrating opioid use disorder prevention and treatment strategies that can be replicated by communities nationwide.

In recent years, the proportion of opioid-related deaths involving co-occurring use of other substances has increased significantly. The Improving Delivery of Healthcare Services for Polysubstance Use program will support research to enhance understanding of why and how polysubstance use occurs and how it can be prevented. By assessing the treatment and recovery needs of people with polysubstance use, this research aims to address how best to meet these needs.

The Justice Community Opioid Innovation Network (JCOIN) aims to enhance quality care for opioid misuse and opioid use disorder in criminal justice-involved populations. JCOIN creates partnerships between local and state justice systems and community-based treatment providers. Its research findings are addressing the critical need to improve the quality of opioid use disorder treatment in the U.S. justice system.

The N CREW Program aims to co-construct and establish a novel way to partner with Tribes and T/NASOs to learn, understand, and meet Native American research needs, in direct response to priorities identified in Tribal Consultations and listening sessions. T/NASOs will be supported to flexibly and agilely respond to the opioid and other drug overdose crisis, in partnership with NIH and other organizations. The N CREW Program is planned as a multi-component program using a variety of funding mechanisms, which may include Other Transactions, Cooperative Agreements, Contracts and/or Grants over the course of the program.

Interventions to prevent and treat opioid use disorder and overdose are only useful if they work effectively in real-world settings. The Optimizing the Quality, Reach, and Impact of Addiction Services program supports action-oriented projects that accelerate research to practice translation, expanding care access and quality of care for all people with a substance use disorder. The program also includes research to support well-being among health and mental health care providers working with people with substance use disorders.

The Recovery Research Networks program focuses on developing multi-stakeholder networks (researchers, payors, providers, people in recovery) to support the development of infrastructure to advance the science of long-term recovery. Five projects form the Consortium on Addiction Recovery Science (CoARS). Collectively, these projects are developing resources to support recovery research centered around community-based recovery centers, justice-involved youth, family-based recovery, recovery in rural settings, and integrated networks of care.

Funded Projects

2023
Data-Driven Approaches for Opioid Use Disorder Treatment, Recovery, and Overdose Prevention in Rural Communities via Mobile Health Clinics and Peer Support Services
Nov 28, 2023
2023
Testing a Video and Text Messaging Intervention to Reduce PTSD and Opioid Misuse Among Sexual Violence Survivors
Nov 28, 2023
2023
Testing an Occupational Stress Intervention for Harm Reduction Workers in Substance Misuse Settings
Nov 28, 2023
2023
HEAL Initiative: Research to Foster an Opioid Use Disorder Treatment System Patients Can Count On
Nov 28, 2023
2023
Evaluation of a Peer Recovery Support Program Adapted to Target Retention in Clinic-Based Medication for Opioid Use Disorder Treatment
Nov 28, 2023

Closed Funding Opportunities

2021
HEAL Initiative: HEAL Data2Action (HD2A) Data Infrastructure Support Center (U24 Clinical Trial Optional)
Dec 30, 2021
2021
HEAL Initiative: HEAL Data2Action Modeling and Economic Resource Center (U24 Clinical Trial Optional)
Dec 30, 2021
2021
HEAL Initiative: HEAL Data2Action Innovation Projects (R61/R33 Clinical Trial Optional)
Dec 30, 2021
2021
HEAL Initiative: Harm Reduction Policies, Practices, and Modes of Delivery for Persons with Substance Use Disorders: Coordination Center (R24 Clinical Trial Optional)
Dec 29, 2021
2021
HEAL Initiative: Understanding Polysubstance Use and Improving Service Delivery to Address Polysubstance Use (R01 Clinical Trial Optional)
Dec 29, 2021

NIH establishes network to improve opioid addiction treatment in criminal justice settings

The National Institutes of Health will award 12 grants to form the Justice Community Opioid Innovation Network (JCOIN) to support research on quality addiction treatment for opioid use disorder (OUD) in criminal justice settings nationwide.

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Logo of the Joe Piscopo Show, featuring an image of Joe Piscopo

Dr. Baker on the HEALing Communities Study

Director of the HEAL Initiative Dr. Rebecca Baker discusses the HEALing Communities Study on AM 970's The Joe Piscopo Show.

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