Overview

There are multiple effective evidence-based treatments and programs for opioid use disorder. Most Americans at risk for or who have this condition, however, do not receive treatment. At the same time, opioid overdoses continue to kill thousands of Americans. To better understand how promising, evidence-based strategies and treatments might help more people with opioid use disorder, the Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, supports implementation research to test the integration of evidence-based interventions in various community settings. 

Open Funding Opportunities

2022
Notice of Special Interest (NOSI): HEAL Initiative: Regarding the Availability of Administrative Supplements to Support the Addition of Justice Measures
Jul 14, 2022
2022
Notice of Special Interest (NOSI): HEAL Initiative: Opioid Use Disorder Care Pathways for Individuals with Histories of Exposure to Violence
Aug 03, 2022
2022
HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)
Aug 03, 2022
2022
HEAL Initiative: Research to Foster an Opioid Use Disorder Treatment System Patients Can Count On (RM1 - Clinical Trial Optional)
Jul 06, 2022

Research Programs

The HEALing Communities Study partners with a diverse set of communities hit hard by the opioid crisis to test the integration of evidence-based strategies for prevention, medication-based treatment, and overdose reversal. This comprehensive treatment model will be tested in a coordinated array of settings, including primary care, emergency departments, and other community settings. The findings will establish best practices for integrating opioid use disorder prevention and treatment strategies that can be replicated by communities nationwide.

Expansion of the National Drug Abuse Treatment Clinical Trials Network (CTN) is addressing emergent needs presented by the opioid and overdose crisis. The CTN integrates new opioid-related research questions into studies currently underway, expedites new studies in general medical and other settings, and enhances clinical and research training opportunities.

The Justice Community Opioid Innovation Network (JCOIN) studies quality care for opioid misuse and opioid use disorder in criminal justice-involved populations. JCOIN creates partnerships between local and state justice systems and community-based treatment providers. The findings will address the critical need to improve the quality of opioid use disorder treatment in the U.S. justice system.

In collaboration with the Substance Abuse and Mental Health Services Administration, the Behavioral Research to Improve Medication-Based Treatment program is studying whether combining behavioral interventions with medication-based treatment for opioid use disorder improves health outcomes for patients with the condition. Behavioral interventions such as mindfulness meditation, cognitive behavioral therapy, and multidisciplinary rehabilitation are being evaluated as ways to increase adherence to medication-based treatment, reduce relapse, and improve health outcomes.

The Recovery Research Networks program focuses on developing multi-stakeholder networks (researchers, payors, providers, people in recovery) to support the development of infrastructure to advance the science of long-term recovery. Five projects form the Consortium on Addiction Recovery Science (CoARS). Collectively, these projects are developing resources to support recovery research centered around community-based recovery centers, justice-involved youth, family-based recovery, recovery in rural settings, and integrated networks of care.

In recent years, the proportion of opioid-related deaths involving co-occurring use of other substances has increased significantly. The Improving Delivery of Healthcare Services for Polysubstance Use program will support research to enhance understanding of why and how polysubstance use occurs and how it can be prevented. By assessing the treatment and recovery needs of people with polysubstance use, this research aims to address how best to meet these needs.

In support of the Administration’s focus on harm reduction to prevent or reduce overdose deaths, the Harm Reduction Approaches to Reduce Overdose Deaths program will establish a harm reduction network of research projects. This research will evaluate the effectiveness, implementation, and impact of existing and new harm reduction approaches.

The Continuum of Care in Hospitalized Patients with Opioid Use Disorder and Infectious Complications of Drug Use (CHOICE) program will evaluate patients hospitalized with an infectious complication of injection drug use and identify and understand gaps in care that arise across the continuum of care. The program will develop an informed intervention to eliminate barriers and improve health outcomes in this population.

Funded Projects

2022
A Network-Based, Mixed Methods Study to Identify and Support Multiple Overdose Responders and Inform Overdose Prevention Interventions
Sep 20, 2022
2022
Culturally Response Integrated Harm Reduction Services for Black and Latinx People Who use Drugs
Sep 20, 2022
2022
RTI HEAL Harm Reduction Network Coordination Center
Sep 20, 2022
2022
Promoting Remote Harm Reduction and Secondary Services in Rural Settings (PROMOTE) Study
Sep 20, 2022
2022
Mobile Health Strategies to Support Longitudinal Engagement in Harm Reduction Services
Sep 20, 2022

Closed Funding Opportunities

2021
HEAL Initiative: HEAL Data2Action (HD2A) Data Infrastructure Support Center (U24 Clinical Trial Optional)
Dec 30, 2021
2021
HEAL Initiative: HEAL Data2Action Modeling and Economic Resource Center (U24 Clinical Trial Optional)
Dec 30, 2021
2021
HEAL Initiative: HEAL Data2Action Innovation Projects (R61/R33 Clinical Trial Optional)
Dec 30, 2021
2021
HEAL Initiative: Pilot & Feasibility Trials to Improve Prevention and Treatment Service Delivery for Polysubstance Use (R34-Clinical Trial Optional)
Dec 29, 2021
2021
HEAL Initiative: Planning Grants for Efficacy or Effectiveness Trials of Recovery Support Services for Individuals Treated with Medications for Opioid Use Disorder (R34 Clinical Trial Optional)
Dec 29, 2021

NIH establishes network to improve opioid addiction treatment in criminal justice settings

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NIH. National Institutes of Health

NIH establishes network to improve opioid addiction treatment in criminal justice settings

The National Institutes of Health will award 12 grants to form the Justice Community Opioid Innovation Network (JCOIN) to support research on quality addiction treatment for opioid use disorder (OUD) in criminal justice settings nationwide.

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Logo of the Joe Piscopo Show, featuring an image of Joe Piscopo

Dr. Baker on the HEALing Communities Study

Director of the HEAL Initiative Dr. Rebecca Baker discusses the HEALing Communities Study on AM 970's The Joe Piscopo Show.

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