NIH HEAL Initiative Budget

Fiscal Years 2019-2023 Budget*

HEAL funds 46 distinct research programs, which are led by most NIH Institutes, Centers, and Offices.

Translation of Research to Practice for the Treatment of Opioid Addiction

• HEALing Communities Study | 344.2M
• Enhancing NIDA Clinical Trial Network to Address Opioids | 211M
• Justice and Community Opioid Innovation Network (JCOIN) | 150.3M
• Behavioral Research to Improve MAT (BRIM) | 42.4M
• Recovery Research Networks | 13.8M
• Harm Reduction Approaches to Reduce Overdose Death | 20.4M
• Improving Delivery of Healthcare Services for Polysubstance Use | 16.1M
• The Continuum of Care in Hospitalized Patients with Opioid Use Disorder and Infectious Complications of Drug Use (CHOICE) | 11M

New Strategies to Prevent and Treat Opioid Addiction

• Optimizing Care for People with OUD and Mental Health Conditions | 67M
• Preventing Opioid Use Disorder (Prevention) | 67.7M
• Sleep Dysfunction as a Core Feature of Opioid Use Disorder and Recovery | 30.7M
• Optimizing the Duration, Retention, and Discontinuation of Medication Treatment for Opioid Use Disorder - CTN | 67.5M
• Prevention of Progression to Moderate or Severe Opioid Use Disorder (STOP) Subsyndromal | 12.5M
• Collaborative Care for Polysubstance Use in Primary Care Settings (Co-Care) | 7.6M
• Monthly Injectable Buprenorphine for Methamphetamine Use Disorder (MURB) | 5.7M **

Enhanced Outcomes for Infants and Children Exposed to Opioids

• Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW) | 84.4M
• HEALthy Brain and Child Development Study (HBCD) Phase II | 59.4M
• The Biology of Opioid Exposure During Pregnancy and Effects on Early Neuro-Behavioral Development | 12M
• Virtual Assessments to Understand Development | 1.25M

Novel Therapeutic Options for Opioid Use Disorder and Overdose

• Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose | 511M
• Development of Novel Immunotherapies for Opioid Addiction | 55.8M
• Oral Complications Arising From Pharmacotherapies to Treat Opioid Use Disorders | 4.4M
• Rapidly Assessing the Public Health Impact of Emerging Opioid Threats | 0.6M

Clinical Research in Pain Management

• Back Pain Consortium Research Program (BACPAC) | 152.7M
• Pain Management Effectiveness Research Network (ERN) | 109.4M
• Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) | 47.7M
• Early Phase Pain Investigation Clinical Network (EPPIC-Net) | 55.8M
• Integrated Approach to Pain and Opioid Use in Hemodialysis Patients (HOPE) | 28.4M
• Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) | 30.8M
• Advancing Health Equity in Pain Management | 17.9M
• Discovery and Validation of Biomarkers, Endpoints and Signatures for Pain Conditions | 59.7M
• Prevention and Management of Chronic Pain in Rural Populations | 3.6M
• Reducing Opioid-Related Harms to Treat Chronic Pain (IMPOWR and MIRHIQL) | 30.889M

Preclinical and Translational Research in Pain Management

• Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain | 116.6M
• Preclinical Screening Platform for Pain (PSPP) | 54.8M
• Translational Research to Advance Testing of Novel Drugs and Human Cell-Based Screening Platforms to Threat Pain and Opioid Use Disorder | 140M
• Translating Discoveries into Effective Devices to Treat Pain  | 75.7M
• Development and Optimization of Non-Addictive Therapies to Treat Pain | 81.4M
• Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN) | 33.2M
• Integrated Basic and Clinical Team-Based Research in Pain | 4.8M

Cross-Cutting Research

• Increasing Participant Diversity, Inclusion and Engagement in HEAL | 17.2M
• Training the Next Generation of Researchers in HEAL | 21.3M
• Leveraging Existing and Real-Time Opioid and Pain Management Data | 68M
• Translating Data 2 Action to Prevent Overdose | 22.7M
• Stigma in Pain Management and Opioid Use Disorder | 1.6M
• Small Business Programs | 118.5M

*The Acute to Chronic Pain Signatures and Stimulating Peripheral Activity to Relieve Conditions (SPARC) programs are supported by the NIH Common Fund and do not appear on this page.

** This program is no longer active.