Funded Projects

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Project # Project Title Research Focus Area Research Program Administering IC Institution(s) Investigator(s) Location(s) Year Awarded
1UG3DA060053-01
Development of a Safer and More Effective Ibogaine Analog for the Treatment of Opioid Use Disorder Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA GILGAMESH PHARMACEUTICALS, INC. MAREK, GERARD JOSEPH New York, NY 2024
NOFO Title: Development of Medications to Prevent and Treat Opioid and/or Stimulant Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
NOFO Number: PAR-22-200
1UG3DA059278-01A1
Development of SBS-226, a MOR agonist / DOR antagonist, for OUD Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA SPARIAN BIOSCIENCES, INC. REICH, JEFFREY New York, NY 2024
NOFO Title: Development of Medications to Prevent and Treat Opioid and/or Stimulant Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
NOFO Number: PAR-22-200
1UG3DA061620-01
Registration Development Program for LUCEMYRA (Lofexidine) Label Expansion for Opioid Withdrawal Treatment in Adolescents Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA USWM, LLC MASSEY, VERONICA LYNCH (contact); SCHMIDT, LEE Louisville, KY 2024
NOFO Title: Development of Medications to Prevent and Treat Opioid and/or Stimulant Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
NOFO Number: PAR-22-200
1U01DA059791-01A1
PF614-MPAR: clinical development of opioid with oral overdose protection Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA ENSYSCE BIOSCIENCES, INC. KIRKPATRICK, LYNN La Jolla, CA 2024
NOFO Title: Grand Opportunity in Medications Development for Substance-Use Disorders (U01 Clinical Trial Optional)
NOFO Number: PAR-22-202
1U01DA060704-01A1
Development of the novel mu-opioid receptor antagonist methocinnamox (MCAM) for preventing relapse and overdose Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER FRANCE, CHARLES P San Antonio, TX 2024
NOFO Title: Grand Opportunity in Medications Development for Substance-Use Disorders (U01 Clinical Trial Optional)
NOFO Number: PAR-22-202
1R61DA060426-01
Evaluating Vending Machines providing Naloxone to Prevent Overdose in American Indian Communities New Strategies to Prevent and Treat Opioid Addiction NIDA UNIVERSITY OF CALIFORNIA SAN DIEGO GAINES, TOMMI LYNN (contact); KNOX, AMY La Jolla, CA 2024
NOFO Title: Time-Sensitive Opportunities for Health Research (R61/R33 Clinical Trial Not Allowed)
NOFO Number: PAR-22-233
1R61DA062217-01
A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk New Strategies to Prevent and Treat Opioid Addiction NIDA BOSTON MEDICAL CENTER BAGLEY, SARAH M (contact); YULE, AMY Boston, MA 2024
NOFO Title: Phased Research to Support Substance Use Epidemiology, Prevention, and Services Studies (R61/R33 Clinical Trials Optional)
NOFO Number: PAR-24-062
4UH3DA048767-03
Development of a Soluble Epoxide Hydrolase Inhibitor to Spare or Replace Opioid Analgesics Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA EICOSIS, LLC CORTES-PUCH, IRENE (contact); HAMMOCK, BRUCE D Davis, CA 2024
NOFO Title: Development of Medications to Prevent and Treat Opioid Use Disorders and Overdose (UG3/UH3) (Clinical Trials Optional)
NOFO Number: RFA-DA-19-002
4UH3DA048338-03
A Long-Acting Bioabsorbable Naltrexone Subcutaneous Implant for Opioid Use Disorder Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA DRUG DELIVERY COMPANY, LLC COHEN, STEVEN M (contact); BENNER, JEFFREY Salisbury, MD 2024
NOFO Title: Development of Medications to Prevent and Treat Opioid Use Disorders and Overdose (UG3/UH3) (Clinical Trials Optional)
NOFO Number: RFA-DA-19-002
1R01DA061773-01
Neurotensin receptor 1 as a novel target for opioid use disorder and discovery of new small molecule probes Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA UNIVERSITY OF MINNESOTA SLOSKY, LAUREN M (contact); OLSON, STEVEN H Minneapolis, MN 2024
NOFO Title: HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R01 Clinical Trial Not Allowed)
NOFO Number: RFA-DA-24-063
1R61DA062357-01
Strength in HEALing: Indigenous Community-Led Strategies to Treat Stimulant Use Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA WASHINGTON STATE UNIVERSITY HIRCHAK, KATHERINE Pullman, WA 2024
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-053
4R33DA059948-02
Workforce and System Change to Treat Adolescent Opioid Use Disorder within Integrated Pediatric Primary Care Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA INDIANA UNIVERSITY INDIANAPOLIS HULVERSHORN, LESLIE A (contact); AALSMA, MATTHEW; ADAMS, ZACHARY WILLIAM Indianapolis, IN 2024
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-053
1R33DA061260-01
Efficacy and implementation considerations for a peer-led motivational interviewing intervention to promote uptake of drug checking services and safer drug use behaviors to reduce overdose Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA UNIVERSITY OF CALIFORNIA SAN DIEGO STRATHDEE, STEFFANIE A (contact); BORQUEZ, ANNICK La Jolla, CA 2024
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-054
1R33DA062346-01
Reversing Overdose Epidemics through Simulation, Collaboration, and Unified Efforts (RESCUE) Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA UNIVERSITY OF MINNESOTA ZANG, XIAO (contact); MARSHALL, BRANDON DAVID LEWIS Minneapolis, MN 2024
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-054
4R33DA059163-02
Supporting data-driven decision-making to support substance use service expansion policies and to prevent overdoses Cross-Cutting Research HEAL Data2Action (HD2A) NIDA CHESTNUT HEALTH SYSTEMS, INC. CRUDEN, GRACELYN Eugene, OR 2024
NOFO Title: HEAL Initiative: HEAL Data2Action Innovation and Acceleration Projects, Phased Awards (R61/R33, Clinical Trial Optional)
NOFO Number: RFA-DA-23-057
1R61DA061831-01
Engaging People Who Use Drugs in Harm Reduction Service Delivery: An Intravention to Reduce Risk of HIV, HCV, Overdose, and Injection-related Infections in Rural Appalachia New Strategies to Prevent and Treat Opioid Addiction NIDA UNIVERSITY OF KENTUCKY YOUNG, APRIL MARIE Lexington, KY 2024
NOFO Title: Rural Community-Centered Drug Misuse Prevention and Harm Reduction Research: Addressing Implementation, Dissemination, and Equity Challenges across the Continuum of Care (R61/R33 Clinical Trial Only)
NOFO Number: RFA-DA-24-036
1R61DA061846-01
Multilevel SUD and Overdose Prevention for Rural Youth Involved in County Legal Systems New Strategies to Prevent and Treat Opioid Addiction NIDA SEATTLE CHILDREN'S HOSPITAL AHRENS, KYM R (contact); MCCARTY, CAROLYN A Seattle, WA 2024
NOFO Title: Rural Community-Centered Drug Misuse Prevention and Harm Reduction Research: Addressing Implementation, Dissemination, and Equity Challenges across the Continuum of Care (R61/R33 Clinical Trial Only)
NOFO Number: RFA-DA-24-036
1R01DA061771-01
Pharmacological targeting of nascent modulators of opioid signaling Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA UNIVERSITY OF FLORIDA MARTEMYANOV, KIRILL A Gainesville, FL 2024
NOFO Title: HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R01 Clinical Trial Not Allowed)
NOFO Number: RFA-DA-24-063
2U2CDA050097-06
JCOIN Phase II Coordination and Translation Center Translation of Research to Practice for the Treatment of Opioid Addiction Justice Community Overdose Innovation Network (JCOIN) NIDA GEORGE MASON UNIVERSITY TAXMAN, FAYE S (contact); HENDERSON, HOWARD; MOLFENTER, TODD DAVID; NICKEL, JESSICA HULSEY; PETTUS, CARRIE; RUDES, DANIELLE SHELDON Fairfax, VA 2024
NOFO Title: HEAL Initiative: Justice Community Overdose Innovation Network (JCOIN) - Phase II Coordination and Translation Center (U2C Clinical Trial Optional)
NOFO Number: RFA-DA-24-069
1R34DA062260-01
Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD adherence to adolescents with OUD New Strategies to Prevent and Treat Opioid Addiction NIDA MARYLAND TREATMENT CENTERS, INC. WENZEL, KEVIN R (contact); FISHMAN, MARC Baltimore, MD 2024
NOFO Title: Adolescent Overdose Prevention and SUD Treatment Initiative (R34 - Clinical Trial Optional)
NOFO Number: RFA-DA-25-031
1R21DA062273-01
Informing national overdose prevention and treatment strategies for high-risk adolescents New Strategies to Prevent and Treat Opioid Addiction NIDA RUTGERS UNIVERSITY BUSHNELL, GRETA (contact); SAMPLES, HILLARY Newark, NJ 2024
NOFO Title: Adolescent Overdose Prevention and SUD Treatment Initiative (R21 - Clinical Trial Not Allowed)
NOFO Number: RFA-DA-25-030
1R21DA062256-01
The Youth Empowerment Study (YES) New Strategies to Prevent and Treat Opioid Addiction NIDA BOSTON MEDICAL CENTER BAGLEY, SARAH M (contact); GREEN, TRACI C Boston, MA 2024
NOFO Title: Adolescent Overdose Prevention and SUD Treatment Initiative (R21 - Clinical Trial Not Allowed)
NOFO Number: RFA-DA-25-030
1R21DA062022-01
Neuropeptide S Receptor 1 as a Novel Target for Reducing Opioid Self-Administration and Opioid Relapse Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER TUNSTALL, BRENDAN Memphis, TN 2024
NOFO Title: HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R21 Clinical Trial Not Allowed)
NOFO Number: RFA-DA-24-064
1R21DA061784-01
Preclinical Trial: Targeting the Neuropeptide S Receptor to Curb Opioid Taking and Seeking Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA STATE UNIVERSITY OF NEW YORK AT BUFFALO CLARK, STEWART DONALDSON Amherst, NY 2024
NOFO Title: HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R21 Clinical Trial Not Allowed)
NOFO Number: RFA-DA-24-064
4UH3DA050323-02
Cannabidiol in the treatment of opioid use disorder Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI HURD, YASMIN L New York, NY 2024
NOFO Title: Development of Medications to Prevent and Treat Opioid Use Disorders and Overdose (UG3/UH3) (Clinical Trials Optional)
NOFO Number: RFA-DA-19-002