Funded Projects

Explore our currently funded projects. You may search with all three fields, then focus your results by applying any of the dropdown filters. After customizing your search, you may download results and even save your specific search for later.

Project # Project Title Research Focus Area Research Program Administering IC Institution(s) Investigator(s) Location(s) Year Awarded
1OT2DA061082-01
Our Healing Journey: A Cultural and Traditional Response to the Opioid Epidemic Translation of Research to Practice for the Treatment of Opioid Addiction Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain NIDA EASTERN SHOSHONE TRIBE WEBB, KELLIE (contact); HIRCHAK, KATHERINE Fort Washakie, WY 2024
NOFO Title: HEAL Initiative: Native Collective Research Effort to Enhance Wellness (N CREW) Program - Addressing Overdose, Substance Use, Mental Health, and Pain (OT2)
NOFO Number: OTA-23-007
1OT2DA061146-01
PERSON-CENTERED RESEARCH ON CULTURE AS HEALTH (PERCH) An Indigenous Model of Wellness Translation of Research to Practice for the Treatment of Opioid Addiction Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain NIDA GREAT LAKES INTER-TRIBAL COUNCIL, INC. LENZ, KADE (contact); DENSLINGER, CHRISTINA Lac du Flambeau, WI 2024
NOFO Title: HEAL Initiative: Native Collective Research Effort to Enhance Wellness (N CREW) Program - Addressing Overdose, Substance Use, Mental Health, and Pain (OT2)
NOFO Number: OTA-23-007
3R01DA057668-01S1
Enhancing Precision in Overdose Mortality Prediction through Data Linkage: A Heterogeneous Capture-Recapture Approach to Estimating Opioid Use Disorder Prevalence in Ohio Cross-Cutting Research Leveraging Existing and Real-Time Opioid and Pain Management Data NIDA OHIO STATE UNIVERSITY FERNANDEZ, SOLEDAD A (contact); FAREED, NALEEF Columbus, OH 2024
NOFO Title: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
NOFO Number: PA-20-272
1UG3DA061620-01
Registration Development Program for LUCEMYRA (Lofexidine) Label Expansion for Opioid Withdrawal Treatment in Adolescents Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA USWM, LLC MASSEY, VERONICA LYNCH (contact); SCHMIDT, LEE Louisville, KY 2024
NOFO Title: Development of Medications to Prevent and Treat Opioid and/or Stimulant Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
NOFO Number: PAR-22-200
4UH3DA050323-02
Cannabidiol in the treatment of opioid use disorder Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI HURD, YASMIN L New York, NY 2024
NOFO Title: Development of Medications to Prevent and Treat Opioid Use Disorders and Overdose (UG3/UH3) (Clinical Trials Optional)
NOFO Number: RFA-DA-19-002
1R61DA061365-01
An innovative, trauma-informed approach for reducing overdose risk among women re-entering the community from prison Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA UNIVERSITY OF KENTUCKY STATON, MICHELE (contact); KNIGHT, KEVIN Lexington, KY 2024
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-053
1R61DA062357-01
Strength in HEALing: Indigenous Community-Led Strategies to Treat Stimulant Use Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA WASHINGTON STATE UNIVERSITY HIRCHAK, KATHERINE Pullman, WA 2024
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-053
1R01DA061773-01
Neurotensin receptor 1 as a novel target for opioid use disorder and discovery of new small molecule probes Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA UNIVERSITY OF MINNESOTA SLOSKY, LAUREN M (contact); OLSON, STEVEN H Minneapolis, MN 2024
NOFO Title: HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R01 Clinical Trial Not Allowed)
NOFO Number: RFA-DA-24-063
1R34DA062280-01
Adapting and Testing a Youth Overdose Prevention Toolkit New Strategies to Prevent and Treat Opioid Addiction NIDA UNIVERSITY OF BRITISH COLUMBIA FAST, DANYA (contact); HADLAND, SCOTT EVAN Vancouver, BC 2024
NOFO Title: Adolescent Overdose Prevention and SUD Treatment Initiative (R34 - Clinical Trial Optional)
NOFO Number: RFA-DA-25-031
1OT2DA061133-01
Understanding Pain Expression in Wabanaki People during Recovery: Enhancing Wabanaki Research, Data Self-Determination, and Capacity Development Translation of Research to Practice for the Treatment of Opioid Addiction Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain NIDA WABANAKI HEALTH AND WELLNESS CAMMACK, RALPH Bangor, ME 2024
NOFO Title: HEAL Initiative: Native Collective Research Effort to Enhance Wellness (N CREW) Program - Addressing Overdose, Substance Use, Mental Health, and Pain (OT2)
NOFO Number: OTA-23-007
1OT2DA061134-01
Promoting Community Wellbeing Through Indigenous Science and Healing Translation of Research to Practice for the Treatment of Opioid Addiction Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain NIDA WASHINGTON STATE UNIVERSITY MCDONELL, MICHAEL G (contact); ECHO-HAWK, ABIGAIL; RASMUS, STACY M; VENNER, KAMILLA L Pullman, WA 2024
NOFO Title: HEAL Initiative: Native Collective Research Effort to Enhance Wellness (N CREW) Program - Addressing Overdose, Substance Use, Mental Health, and Pain Native Research Resource Network (OT2)
NOFO Number: OTA-23-008
1R44DA061722-01
NX90: A Treatment for Overdose Caused by High Potency Opioids Cross-Cutting Research Small Business Programs NIDA SERODOPA THERAPEUTICS, INC. VORONKOV, MICHAEL V Gainesville, FL 2024
NOFO Title: PHS 2023-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
NOFO Number: PA-23-230
1R61DA060426-01
Evaluating Vending Machines providing Naloxone to Prevent Overdose in American Indian Communities New Strategies to Prevent and Treat Opioid Addiction NIDA UNIVERSITY OF CALIFORNIA SAN DIEGO GAINES, TOMMI LYNN (contact); KNOX, AMY La Jolla, CA 2024
NOFO Title: Time-Sensitive Opportunities for Health Research (R61/R33 Clinical Trial Not Allowed)
NOFO Number: PAR-22-233
1R44DA060643-01
Developing a wearable medical device to detect opioid overdose Cross-Cutting Research Small Business Programs NIDA RESILIENT LIFESCIENCE, INC. HOLDEN, BRADFORD A Pittsburgh, PA 2024
NOFO Title: Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders (OUD/StUD) (R43/R44 - Clinical Trial Optional)
NOFO Number: RFA-DA-23-021
1R61DA061340-01A1
PATH to reducing burnout among peers who deliver harm reduction services: Improving workforce and service system outcomes through a combined eLearning and group consultation intervention Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA CHESTNUT HEALTH SYSTEMS, INC. WATSON, DENNIS PAUL Bloomington, IL 2024
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-053
1R33DA062346-01
Reversing Overdose Epidemics through Simulation, Collaboration, and Unified Efforts (RESCUE) Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA UNIVERSITY OF MINNESOTA ZANG, XIAO (contact); MARSHALL, BRANDON DAVID LEWIS Minneapolis, MN 2024
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-054
2UM1DA050098-02
Methodology and Advanced Analytics Resource Center 2.0 Translation of Research to Practice for the Treatment of Opioid Addiction Justice Community Opioid Innovation Network (JCOIN) NIDA UNIVERSITY OF CHICAGO SCHNEIDER, JOHN (contact); BREWER, RUSSELL; POLLACK, HAROLD ALEXANDER Chicago, IL 2024
NOFO Title: HEAL Initiative: Justice Community Overdose Innovation Network (JCOIN) - Phase II Methodology and Advanced Analytics Resource Center (UM1 Clinical Trial Not Allowed)
NOFO Number: RFA-DA-24-068
1RM1DA059365-01
Improving Quality and Equity of Opioid Use Disorder Treatment Using a Multi-State Medicaid Research Network Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA UNIVERSITY OF PITTSBURGH AT PITTSBURGH DONOHUE, JULIE MARIE (contact); BARNES, ANDREW JAMES Pittsburgh, PA 2023
NOFO Title: HEAL Initiative: Research to Foster an Opioid Use Disorder Treatment System Patients Can Count On (RM1 - Clinical Trial Optional)
NOFO Number: RFA-DA-23-046
Summary:

Medicaid covers the cost of treatment for opioid use disorder (OUD) for most individuals who need it, including minoritized populations and those with risk factors related to low income, education, and employment. The Medicaid Outcomes Distributed Research Network has supported efforts to improve OUD treatment by developing novel measures of treatment quality and examining effects of treatment quality on overdoses. Using this network, this project will leverage university-state partnerships in 12 states to inform quality improvement initiatives and Medicaid policy. The research will develop provider-level quality measures for OUD using Medicaid administrative data and measure patient-reported outcomes. The research will also look for approaches to use claims-based quality measures and practice-level quality improvement strategies to improve treatment outcomes for people with OUD.

1R61DA059889-01
Methadone Patient Access to Collaborative Treatment (MPACT) Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA UNIVERSITY OF ARIZONA MEYERSON, BETH Tucson, AZ 2023
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-053
Summary:

Current practices and culture in treatment programs for opioid use disorder, including treatment with methadone, may contribute to treatment interruption and relapse risk. This project will develop and test a staff-level intervention for opioid treatment programs to increase methadone treatment retention and decrease in-treatment overdose and patient- and staff-reported posttraumatic stress symptoms. The intervention includes components to address trauma in patients and staff as well as separate supervisory structures for counselors/case managers and medical providers.

1R61DA059948-01
Workforce and System Change to Treat Adolescent Opioid Use Disorder Within Integrated Pediatric Primary Care Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS HULVERSHORN, LESLIE A (contact); AALSMA, MATTHEW; ADAMS, ZACHARY WILLIAM Indianapolis, IN 2023
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-053
Summary:

The overdose crisis has expanded rapidly among adolescent populations in recent years, largely due to illicit substances containing lethal amounts of the highly potent synthetic opioid fentanyl. However, a provider shortage limits access to effective treatment for adolescents with opioid use disorder and other substance use disorders (SUD). Although primary care is a promising setting for expanding delivery of SUD treatment to adolescents, many primary care providers lack the training, resources, and support systems to deliver these services confidently and effectively. This project will leverage a large-scale rollout of integrated behavioral health care in a statewide health system. The research will test whether embedding behavioral health specialists into primary care visits, introducing case management and electronic clinical decision support tools, and reducing stigma will increase delivery of SUD treatment to adolescents.

1R61DA059895-01
Promoting Retention in Opioid Treatment among Women Experiencing Intimate Partner Violence: A Novel Stepped Care Model Targeting PTSD Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA YALE UNIVERSITY SULLIVAN, TAMI P (contact); EDELMAN, E JENNIFER; JOHNSON, DAWN M New Haven, CT 2023
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-053
Summary:

Women with opioid use disorder (OUD) are disproportionately impacted by physical, sexual, and psychological intimate partner violence and posttraumatic stress disorder (PTSD). Yet, treatment approaches that address all these conditions together in OUD treatment settings are lacking. To address this gap, this project will evaluate delivery of two evidence-based interventions to address PTSD (Present-Centered Therapy+ and Helping to Overcome PTSD through Empowerment) for women seeking OUD treatment who have experienced intimate partner violence. It will also determine if integrated treatment can help retain the women in medication treatment for OUD.

1RM1DA059377-01
Person-Centered Quality Measurement and Management in a System for Addictions Treatment in New York State Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA NEW YORK UNIVERSITY SCHOOL OF MEDICINE NEIGHBORS, CHARLES J (contact); BURKE, CONSTANCE; LINCOURT, PATRICIA New York, NY 2023
NOFO Title: HEAL Initiative: Research to Foster an Opioid Use Disorder Treatment System Patients Can Count On (RM1 - Clinical Trial Optional)
NOFO Number: RFA-DA-23-046
Summary:

The number of drug overdoses in New York continues to rise. In response, the New York State Office of Addiction Services and Supports (OASAS) is promoting approaches that embrace person-centered care, evidence-based practices, equitable treatment, and harm-reduction principles. In this project, researchers will partner with OASAS to build a quality measurement and management research center that provides performance feedback to support and encourage leadership and staff of treatment clinics to improve practice. The center will also publicize quality measures to ensure public accountability.

1R61DA059947-01
Developing and Testing Innovative Care Pathways for Screening and Treatment of OUD/PTSD in Jails Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES ZIELINSKI, MELISSA JEAN (contact); ZALLER, NICKOLAS D Little Rock, AR 2023
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-053
Summary:

Many people in jail have both opioid use disorder (OUD) and posttraumatic stress disorder (PTSD). Among people with OUD released from jail, only few engage in treatment and medication therapy once they are back in the community, and opioid overdose is a leading cause of death in this population. This project will test whether identifying and initiating treatment of PTSD in people receiving OUD treatment in jail can increase these individuals’ likelihood of starting and staying in medication treatment after release and thus reduce overdose risk.

1UG1DA059406-01
Development and Validation of a Novel Point-of-Care Technology for Rapid Non-Targeted Identification of Emerging Opioid and Other Drug Threats Novel Therapeutic Options for Opioid Use Disorder and Overdose Rapidly Assessing the Public Health Impact of Emerging Opioid Threats NIDA UNIVERSITY OF CALIFORNIA, SAN DIEGO WERB, DANIEL M (contact); HALL, DREW ALEXANDER La Jolla, CA 2023
NOFO Title: HEAL Initiative: Rapidly Assessing the Public Health Impact of Emerging Opioid Threats (UG1 - Clinical Trial Not Allowed)
NOFO Number: RFA-DA-23-045
Summary:

Drug checking services provide individuals who use drugs with information about the true contents of their purchases, and thus may help prevent overdoses. However, current technologies are either costly, technically complex, and non-portable or subject to false signals and restricted in their detection capabilities. This project will continue development of a new, simple-to-use, point-of-care analytical technology (DoseCheck) that can rapidly detect established drug threats in a sample and recognize newly emerging drugs. The project will also attempt to adapt DoseCheck to provide rapid results in emergency overdose situations and improve the analytical capabilities of medical examiners in under-resourced jurisdictions.

1R61DA059892-01
Data-Driven Approaches for Opioid Use Disorder Treatment, Recovery, and Overdose Prevention in Rural Communities via Mobile Health Clinics and Peer Support Services Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA CLEMSON UNIVERSITY RENNERT, LIOR (contact); LITWIN, ALAIN HARRIS Clemson, SC 2023
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-053
Summary:

Although medication-based treatment for opioid use disorder (OUD) can effectively reduce overdose risk and improve health outcomes, most people discontinue treatment too soon. Peer support specialists, who are individuals with direct experience with a substance use disorder, can offer social support to help individuals with OUD overcome barriers to treatment and recovery. This project will develop, deliver, and evaluate an innovative peer support specialist intervention to help individuals begin and stay in a treatment program. The research will focus on rural populations and underserved communities, using a dynamic modeling framework to prioritize at-risk communities for treatment offered through mobile health clinics.