Funded Projects

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Project # Project Title Research Focus Area Research Program Administering IC Institution(s) Investigator(s) Location(s) Year Awarded
1R01DE032676-01A1
Identification and validation of LPA/LPAR signaling as a target for the treatment of temporomandibular disorder pain Preclinical and Translational Research in Pain Management NIDCR DUKE UNIVERSITY CHEN, YONG (contact); NACKLEY, ANDREA G Durham, NC 2024
NOFO Title: HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-034
1R01DE033674-01
Targeting Schwann cell dysfunction and repair signaling in chemotherapy induced painful peripheral neuropathy Preclinical and Translational Research in Pain Management NIDCR NEW YORK UNIVERSITY YE, YI (contact); CAMPANA, WENDY M New York, NY 2024
NOFO Title: HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-034
1RF1AG088052-01
Validation of neuronal senescence as a target for chronic pain in aging Preclinical and Translational Research in Pain Management Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain NIA STANFORD UNIVERSITY TAWFIK, VIVIANNE L Stanford, CA 2024
NOFO Title: HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-034
1RF1NS132920-01A1
Dissecting the role of mPFC dynorphin circuits in the modulation of different pain states Preclinical and Translational Research in Pain Management Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain NINDS INDIANA UNIVERSITY SHEETS, PATRICK L Indianapolis, IN 2024
NOFO Title: HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-034
1RF1NS136108-01
Cellular Mechanisms and Therapeutic Potential of NR4A1 in Pain Resolution Preclinical and Translational Research in Pain Management Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain NINDS UNIVERSITY OF CINCINNATI BERTA, TEMUGIN Cincinnati, OH 2024
NOFO Title: HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-034
1UG3NS138882-01
Developing AI-Driven Pain Intensity and Pain Sensitization Biomarker Signatures to Optimize Neonatal Pain Management Clinical Research in Pain Management Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions NINDS UNIVERSITY OF SOUTH FLORIDA SUN, YU (contact); ANAND, KANWALJEET S; HO, THAO ; PRESCOTT, STEPHANIE Tampa, FL 2024
NOFO Title: HEAL Initiative: Discovery of Biomarkers and Biomarker Signatures to Facilitate Clinical Trials for Pain Therapeutics (UG3/UH3 Clinical Trial Optional)
NOFO Number: RFA-NS-24-018
4U24NS113784-02
University of Rochester Hub and Spokes for the EPPIC Network - Specialized Clinical Center Clinical Research in Pain Management Early Phase Pain Investigation Clinical Network (EPPIC-Net) NINDS UNIVERSITY OF ROCHESTER GEWANDTER, JENNIFER Rochester, NY 2024
NOFO Title: HEAL Initiative: Early Phase Pain Investigation Clinical Network - Specialized Clinical Centers (U24 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-19-025
4U24NS113849-02
The Icahn School of Medicine at Mount Sinai (ISMMS) EPPIC-Net Specialized Clinical Center Clinical Research in Pain Management Early Phase Pain Investigation Clinical Network (EPPIC-Net) NINDS ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ROBINSON-PAPP, JESSICA New York, NY 2024
NOFO Title: HEAL Initiative: Early Phase Pain Investigation Clinical Network - Specialized Clinical Centers (U24 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-19-025
4U24NS115678-02
EPPIC-Net Hub at University of Washington Clinical Research in Pain Management Early Phase Pain Investigation Clinical Network (EPPIC-Net) NINDS UNIVERSITY OF WASHINGTON PATEL, KUSHANG (contact); CURATOLO, MICHELE ; STACEY, BRETT Seattle, WA 2024
NOFO Title: HEAL Initiative: Early Phase Pain Investigation Clinical Network - Specialized Clinical Centers (U24 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-19-036
4U24NS115708-02
University of Pittsburgh Hub and Spoke Pain Clinical Trial Network Clinical Research in Pain Management Early Phase Pain Investigation Clinical Network (EPPIC-Net) NINDS UNIVERSITY OF PITTSBURGH WASAN, AJAY D (contact); ALTER, BENEDICT J Pittsburgh, PA 2024
NOFO Title: HEAL Initiative: Early Phase Pain Investigation Clinical Network - Specialized Clinical Centers (U24 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-034
4U24NS115714-02
California Clinical and Translational Pain Research Consortium Clinical Research in Pain Management Early Phase Pain Investigation Clinical Network (EPPIC-Net) NINDS UNIVERSITY OF CALIFORNIA SAN DIEGO WALLACE, MARK S La Jolla, CA 2024
NOFO Title: HEAL Initiative: Early Phase Pain Investigation Clinical Network - Specialized Clinical Centers (U24 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-034
1U24HD116261-01
Duke-Utah HEAL KIDS Pain Resource and Data Center Clinical Research in Pain Management NICHD DUKE UNIVERSITY GREENBERG, RACHEL G (contact); BENJAMIN, DANIEL K; SWARD, KATHERINE ANN; WATT, KEVIN M Durham, NC 2024
NOFO Title: HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain Program Resource and Data Center (U24 Clinical Trial Not Allowed)
NOFO Number: RFA-HD-24-012
1U01HD116253-01
Efficacy of intravenous sub-dissociative ketamine versus intravenous morphine in children with acute pain. Clinical Research in Pain Management NICHD COLUMBIA UNIVERSITY TSZE, DANIEL SING-KWONG (contact); DRENDEL, AMY L New York, NY 2024
NOFO Title: HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain: Acute Pain Clinical Trials Program (U01 Clinical Trial Required)
NOFO Number: RFA-HD-24-011
1U01HD116257-01
Implementing and Personalizing Best-In-Class Opioid-sparing Pain Management for Major Inpatient Surgeries in Children Clinical Research in Pain Management NICHD UNIVERSITY OF PITTSBURGH SADHASIVAM, SENTHILKUMAR (contact); CHIDAMBARAN, VIDYA Pittsburgh, PA 2024
NOFO Title: HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain: Acute Pain Clinical Trials Program (U01 Clinical Trial Required)
NOFO Number: RFA-HD-24-011
1U01HD116260-01
Optimizing Pain Treatment In Children On Mechanical ventilation (OPTICOM) Clinical Research in Pain Management NICHD CORNELL UNIVERSITY TRAUBE, CHANI (contact); BELL, MICHAEL J; HOLUBKOV, RICHARD New York, NY 2024
NOFO Title: HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain: Acute Pain Clinical Trials Program (U01 Clinical Trial Required)
NOFO Number: RFA-HD-24-011
4K12NS130673-02
University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP) Training the Next Generation of Researchers in HEAL NINDS UNIVERSITY OF MICHIGAN WILLIAMS, DAVID A (contact); CLAUW, DANIEL J; HARTE, STEVEN EDWARD Ann Arbor, MI 2024
NOFO Title: HEAL Initiative: National K12 Clinical Pain Career Development Program (K12 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-045
3K12NS130673-02S1
University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP) Training the Next Generation of Researchers in HEAL NINDS UNIVERSITY OF MICHIGAN WILLIAMS, DAVID A (contact); CLAUW, DANIEL J; HARTE, STEVEN EDWARD Ann Arbor, MI 2024
NOFO Title: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
NOFO Number: PA-20-272
1UG3NS135350-01A1
A novel oral immunotherapy for chronic visceral pain of irritable bowel syndrome Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS FZATA, INC. YANG, ZHIYONG (contact); FENG, HANPING ; WEI, FENG Halethorpe, MD 2024
NOFO Title: HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
NOFO Number: RFA-NS-21-010
4UH3NS127943-02
Oral N2O Therapy in Treating Acute Vaso-Occlusive Pain in Sickle Cell Disease Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS HILLHURST BIOPHARMACEUTICALS, INC. GOMPERTS, EDWARD (contact); BELCHER, JOHN D; SIMONE, DONALD Montrose, CA 2024
NOFO Title: HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
NOFO Number: RFA-NS-21-010
1R61NS131246-01A1
Development of CNS-Active 5-HT3R Antagonists for the Treatment of Neuropathic Pain Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS WASHINGTON UNIVERSITY IN ST. LOUIS ELGENDY, BAHAA (contact); HAROUTOUNIAN, SIMON ; HEGAZY, LAMEES Saint Louis, MO 2024
NOFO Title: HEAL Initiative: Planning Studies for Initial Analgesic Development [Small Molecules and Biologics] (R61 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-21-029
1R61NS131303-01A1
Topical Neurokinin-1 Receptor Antagonist as an Effective Non-addictive Analgesic for Ocular Pain Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS SCHEPENS EYE RESEARCH INSTITUTE DANA, REZA (contact); CHEN, YIHE Boston, MA 2024
NOFO Title: HEAL Initiative: Planning Studies for Initial Analgesic Development [Small Molecules and Biologics] (R61 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-21-029
1R61NS136307-01
Development of PAC1 receptor antagonists for the treatment of Headache Disorders Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS WASHINGTON UNIVERSITY IN ST. LOUIS PRADHAN, AMYNAH AMIR ALI (contact); KATRITCH, VSEVOLOD ; MAJUMDAR, SUSRUTA Saint Louis, MO 2024
NOFO Title: HEAL Initiative: Planning Studies for Initial Analgesic Development [Small Molecules and Biologics] (R61 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-21-029
1R61NS138215-01
Developing equilibrative nucleoside transporter inhibitors as non-opioid pain therapeutics Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS DUKE UNIVERSITY LEE, SEOK-YONG (contact); HONG, JIYONG ; JI, RU-RONG Durham, NC 2024
NOFO Title: HEAL Initiative: Planning Studies for Initial Analgesic Development [Small Molecules and Biologics] (R61 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-21-029
1R61NS138976-01
Development of selective GPR34 antagonists for the treatment of neuropathic pain Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS SAINT LOUIS UNIVERSITY SALVEMINI, DANIELA (contact); ARNATT, CHRISTOPHER K; WALKER, JOHN K Saint Louis, MO 2024
NOFO Title: HEAL Initiative: Planning Studies for Initial Analgesic Development [Small Molecules and Biologics] (R61 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-21-029
1UG3AT012728-01
Personalized Auricular Point Acupressure for Chronic Pain Self-Management in Rural Populations Clinical Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NCCIH UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON KAWI, JENNIFER (contact); BOLIN, JANE N; WU, HULIN Houston, TX 2024
NOFO Title: HEAL Initiative: Prevention and Management of Chronic Pain in Rural Populations (UG3/UH3, Clinical Trials Required)
NOFO Number: RFA-NR-23-001