|Project #||Project Title||Research Focus Area||Research Program||Administering IC||Institution(s)||Investigator(s)||Location(s)||Year Awarded|
|Using Mouse Pain Scales to Discover Unusual Pain Sensitivity and New Pain Targets||Cross-Cutting Research||Training the Next Generation of Researchers in HEAL||NINDS||COLUMBIA UNIV NEW YORK MORNINGSIDE||ABDUS-SABOOR, ISHMAIL JOHN||New York, NY||2022|
NOFO Title: Emergency Awards: HEAL Initiative- New Innovator Award (DP2 Clinical Trial Not Allowed)
NOFO Number: RFA-TR-22-013
Acute and chronic pain vary widely across patients, due in large part to genetic differences between individuals. The same variation occurs in preclinical animal models with diverse genetic backgrounds. The development of automated mouse “pain scales” using high-speed videography, machine learning, and custom software allows pain to be assessed in a quantitative manner in nonverbal animals. This technology will be used to identify genetically different mice with high or low pain sensitivity, which will facilitate the development of new therapeutic strategies to treat pain and reduce reliance on opioids.