Funded Projects

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Project # Project Title Research Focus Area Research Program Administering IC Institution(s) Investigator(s) Location(s) Year Awarded
1R01AR085334-01
Psychometric Reliability and Validity for Behavioral Metrics of Osteoarthritic Pain in Horses Preclinical and Translational Research in Pain Management NIAMS UNIVERSITY OF FLORIDA ALLEN, KYLE D (contact); BIEDRZYCKI, ADAM H; BROOKS, SAMANTHA A; CRUZ-ALMEIDA, YENISEL Gainesville, FL 2024
NOFO Title: HEAL Initiative: Development and Validation of Non-Rodent Mammalian Models of Pain(R01 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-070
1R01AR085335-01
Innovative modeling of the biopsychosocial model in animals: Validation of outcomes for assessing emotional and cognitive domains affected by naturally-occurring chronic pain in dogs Preclinical and Translational Research in Pain Management NIAMS NORTH CAROLINA STATE UNIVERSITY GRUEN, MARGARET ELIZABETH (contact); HARE, BRIAN ; LASCELLES, DUNCAN Raleigh, NC 2024
NOFO Title: HEAL Initiative: Development and Validation of Non-Rodent Mammalian Models of Pain(R01 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-070
1R01DE032676-01A1
Identification and validation of LPA/LPAR signaling as a target for the treatment of temporomandibular disorder pain Preclinical and Translational Research in Pain Management NIDCR DUKE UNIVERSITY CHEN, YONG (contact); NACKLEY, ANDREA G Durham, NC 2024
NOFO Title: HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-034
1R01DE033674-01
Targeting Schwann cell dysfunction and repair signaling in chemotherapy induced painful peripheral neuropathy Preclinical and Translational Research in Pain Management NIDCR NEW YORK UNIVERSITY YE, YI (contact); CAMPANA, WENDY M New York, NY 2024
NOFO Title: HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-034
1RF1AG088052-01
Validation of neuronal senescence as a target for chronic pain in aging Preclinical and Translational Research in Pain Management Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain NIA STANFORD UNIVERSITY TAWFIK, VIVIANNE L Stanford, CA 2024
NOFO Title: HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-034
1RF1NS132920-01A1
Dissecting the role of mPFC dynorphin circuits in the modulation of different pain states Preclinical and Translational Research in Pain Management Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain NINDS INDIANA UNIVERSITY SHEETS, PATRICK L Indianapolis, IN 2024
NOFO Title: HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-034
1RF1NS136108-01
Cellular Mechanisms and Therapeutic Potential of NR4A1 in Pain Resolution Preclinical and Translational Research in Pain Management Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain NINDS UNIVERSITY OF CINCINNATI BERTA, TEMUGIN Cincinnati, OH 2024
NOFO Title: HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-034
1UG3NS135350-01A1
A novel oral immunotherapy for chronic visceral pain of irritable bowel syndrome Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS FZATA, INC. YANG, ZHIYONG (contact); FENG, HANPING ; WEI, FENG Halethorpe, MD 2024
NOFO Title: HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
NOFO Number: RFA-NS-21-010
4UH3NS127943-02
Oral N2O Therapy in Treating Acute Vaso-Occlusive Pain in Sickle Cell Disease Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS HILLHURST BIOPHARMACEUTICALS, INC. GOMPERTS, EDWARD (contact); BELCHER, JOHN D; SIMONE, DONALD Montrose, CA 2024
NOFO Title: HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
NOFO Number: RFA-NS-21-010
1R61NS131246-01A1
Development of CNS-Active 5-HT3R Antagonists for the Treatment of Neuropathic Pain Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS WASHINGTON UNIVERSITY IN ST. LOUIS ELGENDY, BAHAA (contact); HAROUTOUNIAN, SIMON ; HEGAZY, LAMEES Saint Louis, MO 2024
NOFO Title: HEAL Initiative: Planning Studies for Initial Analgesic Development [Small Molecules and Biologics] (R61 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-21-029
1R61NS131303-01A1
Topical Neurokinin-1 Receptor Antagonist as an Effective Non-addictive Analgesic for Ocular Pain Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS SCHEPENS EYE RESEARCH INSTITUTE DANA, REZA (contact); CHEN, YIHE Boston, MA 2024
NOFO Title: HEAL Initiative: Planning Studies for Initial Analgesic Development [Small Molecules and Biologics] (R61 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-21-029
1R61NS136307-01
Development of PAC1 receptor antagonists for the treatment of Headache Disorders Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS WASHINGTON UNIVERSITY IN ST. LOUIS PRADHAN, AMYNAH AMIR ALI (contact); KATRITCH, VSEVOLOD ; MAJUMDAR, SUSRUTA Saint Louis, MO 2024
NOFO Title: HEAL Initiative: Planning Studies for Initial Analgesic Development [Small Molecules and Biologics] (R61 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-21-029
1R61NS138215-01
Developing equilibrative nucleoside transporter inhibitors as non-opioid pain therapeutics Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS DUKE UNIVERSITY LEE, SEOK-YONG (contact); HONG, JIYONG ; JI, RU-RONG Durham, NC 2024
NOFO Title: HEAL Initiative: Planning Studies for Initial Analgesic Development [Small Molecules and Biologics] (R61 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-21-029
1R61NS138976-01
Development of selective GPR34 antagonists for the treatment of neuropathic pain Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS SAINT LOUIS UNIVERSITY SALVEMINI, DANIELA (contact); ARNATT, CHRISTOPHER K; WALKER, JOHN K Saint Louis, MO 2024
NOFO Title: HEAL Initiative: Planning Studies for Initial Analgesic Development [Small Molecules and Biologics] (R61 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-21-029
1U19NS138975-01
Developing small molecules to engage an analgesic GPCR in pain unpleasantness neural circuits Preclinical and Translational Research in Pain Management Development and Optimization of Non-Addictive Therapies to Treat Pain NINDS UNIVERSITY OF NORTH CAROLINA SCHERRER, GREGORY (contact); AUBE, JEFFREY ; SCHNITZER, MARK J Chapel Hill, NC 2024
NOFO Title: HEAL Initiative: Team Research for Initial Translational Efforts in Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] (U19 Clinical Trial Not Allowed)
NOFO Number: RFA-NS-22-052
1R61AT012270-01A1
Development and Clinical Translation of RPBM for Quantitative Assessment of Myofascial Pain Preclinical and Translational Research in Pain Management Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions NCCIH CORNELL UNIVERSITY KIM, SUNGHEON GENE (contact); FIEREMANS, ELS ; NOVIKOV, DMITRY S; REEVE, GWENDOLYN New York, NY 2024
NOFO Title: HEAL Initiative: Toward Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management (R61/R33, Clinical Trial Required)
NOFO Number: RFA-AT-24-003
1R61AT012275-01A1
Development of diagnostic and prognostic ultrasound imaging biomarkers for plantar heel pain Preclinical and Translational Research in Pain Management Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions NCCIH UNIVERSITY OF IOWA CHIMENTI, RUTH LOUISE PORTER (contact); HOLMES, JAMES H; SLUKA, KATHLEEN A Iowa City, IA 2024
NOFO Title: HEAL Initiative: Toward Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management (R61/R33, Clinical Trial Required)
NOFO Number: RFA-AT-24-003
1R61AT013008-01
Quantitative Assessment of Pelvic Floor Muscle Fitness in Myofascial Pelvic Pain Preclinical and Translational Research in Pain Management Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions NCCIH UNIVERSITY OF CALIFORNIA LOS ANGELES ACKERMAN, A. LENORE Los Angeles, CA 2024
NOFO Title: HEAL Initiative: Toward Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management (R61/R33, Clinical Trial Required)
NOFO Number: RFA-AT-24-003
1R61EB036967-01
Imaging of pain sources in myofascial pain syndrome Preclinical and Translational Research in Pain Management Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions NIBIB STANFORD UNIVERSITY GOLD, GARRY E (contact); KOGAN, FELIKS Stanford, CA 2024
NOFO Title: HEAL Initiative: Toward Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management (R61/R33, Clinical Trial Required)
NOFO Number: RFA-AT-24-003
1R18EB036591-01
Transspinal Magnetic Stimulation for the Treatment of Neuropathic Pain Preclinical and Translational Research in Pain Management Translating Discoveries into Effective Devices to Treat Pain NIBIB MASSACHUSETTS GENERAL HOSPITAL BONMASSAR, GIORGIO Boston, MA 2024
NOFO Title: HEAL Initiative: Translational Development of Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed)
NOFO Number: RFA-EB-22-002
1R01HD116714-01
Targeting Interindividual Variability in NSAID Responses to Mitigate Chronic Pelvic Pain Risk in Dysmenorrhea Preclinical and Translational Research in Pain Management NICHD NORTHSHORE UNIVERSITY HELLMAN, KEVIN Evanston, IL 2024
NOFO Title: HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 - Clinical Trial Optional)
NOFO Number: RFA-NS-24-021
1R61NS133083-01A1
Establishment and Validation of a Novel Animal Model of Fibromyalgia Preclinical and Translational Research in Pain Management NINDS MASSACHUSETTS GENERAL HOSPITAL MAO, JIANREN Boston, MA 2024
NOFO Title: Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery (R61/R33 Clinical Trial Not Allowed)
NOFO Number: PAR-21-123
1R61NS133264-01A1
Validation of a Translational Model of Chronic Discogenic Low Back Pain Preclinical and Translational Research in Pain Management NINDS ARIZONA STATE UNIVERSITY WACHS, REBECCA ANN (contact); KING, TAMARA E Tempe, AZ 2024
NOFO Title: Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery (R61/R33 Clinical Trial Not Allowed)
NOFO Number: PAR-21-123
1R61NS133274-01A1
A novel platform for the discovery and characterization of migraine therapies Preclinical and Translational Research in Pain Management NINDS UNIVERSITY OF CALIFORNIA LOS ANGELES CHARLES, ANDREW C (contact); PRADHAN, AMYNAH AMIR ALI Los Angeles, CA 2024
NOFO Title: Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery (R61/R33 Clinical Trial Not Allowed)
NOFO Number: PAR-21-123
1R61NS136569-01A1
Development and Validation of a Mouse Model of Intervertebral Disc Degeneration-Induced Low Back Pain to Facilitate Non-Addictive Analgesic Discovery Preclinical and Translational Research in Pain Management NINDS UNIVERSITY OF MINNESOTA STONE, LAURA S Minneapolis, MN 2024
NOFO Title: Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery (R61/R33 Clinical Trial Not Allowed)
NOFO Number: PAR-21-123