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Why HEAL?
The Opioid Crisis
Making a Difference
NIH HEAL Initiative Leadership
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Strategic Planning
Research
Translation of Research to Practice for the Treatment of Opioid Addiction
Behavioral Research to Improve Medication-Based Treatment
The Continuum of Care in Hospitalized Patients with Opioid Use Disorder and Infectious Complications of Drug Use
Enhancing the National Drug Abuse Treatment Clinical Trials Network to Address Opioids
Harm Reduction Research Network
HEALing Communities Study
Improving Delivery of Healthcare Services for Polysubstance Use
Justice Community Opioid Innovation Network
Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain
Optimizing the Quality, Reach, and Impact of Addiction Services
Recovery Research Networks
New Strategies to Prevent and Treat Opioid Addiction
Collaborative Care for Polysubstance use in Primary Care Settings (Co-Care)
Optimizing Care for People with Opioid Use Disorder and Mental Health Conditions
Optimizing the Duration, Retention, and Discontinuation of Medication Treatment for Opioid Use Disorder
Preventing Opioid Use Disorder
Prevention of Progression to Moderate or Severe Opioid Use Disorder
Sleep Dysfunction as a Core Feature of Opioid Use Disorder and Recovery
Enhanced Outcomes for Infants and Children Exposed to Opioids
Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW)
The Biology of Opioid Exposure During Pregnancy and Effects on Early Neuro-Behavioral Development
HEALthy Brain and Child Development Study (HBCD)
Virtual Assessments to Understand Developmental Trajectories of Substance Use Exposure
Novel Therapeutic Options for Opioid Use Disorder and Overdose
Development of Novel Immunotherapeutics for Opioid Addiction
Focusing Medication Development to Prevent and Treat Opioid Use Disorders and Overdose
Oral Complications Arising From Pharmacotherapies to Treat Opioid Use Disorders
Rapidly Assessing the Public Health Impact of Emerging Opioid Threats
Clinical Research in Pain Management
Advancing Health Equity in Pain Management
Acute to Chronic Pain Signatures Program
Back Pain Consortium Research Program
Discovery and Validation of Biomarkers, Endpoints and Signatures for Pain Conditions
Early Phase Pain Investigation Clinical Network (EPPIC-Net)
Integrated Approach to Pain and Opioid Use in Hemodialysis Patients
Pain Management Effectiveness Research Network
Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM)
Prevention and Management of Chronic Pain in Rural Populations
Reducing Opioid-Related Harms to Treat Chronic Pain (IMPOWR and MIRHIQL)
Preclinical and Translational Research in Pain Management
Development and Optimization of Non-Addictive Therapies to Treat Pain
Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain
Integrated Basic and Clinical Team-Based Research in Pain
Preclinical Screening Platform for Pain
Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN)
Translating Discoveries into Effective Devices to Treat Pain
Translational Research to Advance Testing of Novel Drugs and Human Cell-Based Screening Platforms to Treat Pain and Opioid Use Disorder
Cross-Cutting Research
Leveraging Existing and Real-Time Opioid and Pain Management Data
Small Business Programs
Stigma in Pain Management and Opioid Use Disorder
HEAL Data2Action (HD2A)
Training the Next Generation of Researchers in HEAL
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About the HEAL Data Ecosystem
Complying With the HEAL Data Sharing Policy
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Research Focus Area
Clinical Research in Pain Management
Cross-Cutting Research
Enhanced Outcomes for Infants and Children Exposed to Opioids
New Strategies to Prevent and Treat Opioid Addiction
Novel Therapeutic Options for Opioid Use Disorder and Overdose
Preclinical and Translational Research in Pain Management
Training the Next Generation of Researchers in HEAL
Translation of Research to Practice for the Treatment of Opioid Addiction
Research Program
Acute to Chronic Pain Signatures Program
Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW)
Advancing Health Equity in Pain Management
Back Pain Consortium Research Program
Behavioral Research to Improve Medication-Based Treatment
Collaborative Care for Polysubstance Use in Primary Care Settings (Co-Care)
Development and Optimization of Non-Addictive Therapies to Treat Pain
Development of Novel Immunotherapeutics for Opioid Addiction
Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions
Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain
Early Phase Pain Investigation Clinical Network (EPPIC-Net)
Enhancing the National Drug Abuse Treatment Clinical Trials Network to Address Opioids
Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose
Harm Reduction Research Network
HEAL Data2Action (HD2A)
HEALing Communities Study
HEALthy Brain and Child Development (HBCD) Study
Improving Delivery of Healthcare Services for Polysubstance Use
Integrated Approach to Pain and Opioid Use in Hemodialysis Patients
Integrated Basic and Clinical Team-Based Research in Pain
Justice Community Overdose Innovation Network (JCOIN)
Leveraging Existing and Real-Time Opioid and Pain Management Data
Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain
Optimizing Care for People with Opioid Use Disorder and Mental Health Conditions
Optimizing the Duration, Retention, and Discontinuation of Medication Treatment for Opioid Use Disorder
Optimizing the Quality, Reach, and Impact of Addiction Services
Oral Complications Arising From Pharmacotherapies to Treat Opioid Use Disorders
Pain Management Effectiveness Research Network (ERN)
Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM)
Preclinical Screening Platform for Pain
Preventing Opioid Use Disorder
Prevention and Management of Chronic Pain in Rural Populations
Prevention of Progression to Moderate or Severe Opioid Use Disorder
Rapidly Assessing the Public Health Impact of Emerging Opioid Threats
Recovery Research Networks
Reducing Opioid-Related Harms to Treat Chronic Pain (IMPOWR and MIRHIQL)
Restoring Joint Health and Function to Reduce Pain (RE-JOIN)
Sleep Dysfunction as a Core Feature of Opioid Use Disorder and Recovery
Small Business Programs
Stigma in Pain Management and Opioid Use Disorder
The Biology of Opioid Exposure During Pregnancy and Effects on Early Neuro-Behavioral Development
The Continuum of Care in Hospitalized Patients with Opioid Use Disorder and Infectious Complications of Drug Use (CHOICE)
Translating Discoveries into Effective Devices to Treat Pain
Translational Research to Advance Testing of Novel Drugs and Human Cell-Based Screening Platforms to Treat Pain and Opioid Use Disorder
Virtual Assessments to Understand Developmental Trajectories of Substance Use Exposure
HEAL Initiative Goal
Improve treatments for opioid addiction and overdose
Enhance pain management
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Page last updated August 22, 2023
U.S. Department of Health & Human Services
