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NOFO # NOFO Title Research Focus Area Research Program
RFA-NS-19-036 HEAL Initiative: Early Phase Pain Investigation Clinical Network - Specialized Clinical Centers (U24 Clinical Trial Not Allowed) Clinical Research in Pain Management Early Phase Pain Investigation Clinical Network (EPPIC-Net)
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NOT-AR-20-016 HEAL Initiative: Back Pain Consortium (BACPAC) Research Program Notice of Special Interest (NOSI) regarding the Availability of Urgent Competitive Revisions Clinical Research in Pain Management Back Pain Consortium Research Program
no summary
RFA-NS-20-028 HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) Clinical Research in Pain Management Pain Management Effectiveness Research Network (ERN)
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RFA-AT-20-004 HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional) Clinical Research in Pain Management Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM)
no summary
NOT-NS-20-044 Notice of Special Interest to Encourage Eligible NIH HEAL Initiative Awardees to Apply for Administrative Supplements to Promote Training in Clinical Research on Pain (Admin Supp – Clinical Trial Not Allowed) Clinical Research in Pain Management Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
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RFA-DA-21-029 HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Coordination and Dissemination Center (R24 Clinical Trial Optional) Clinical Research in Pain Management Reducing Opioid-Related Harms to Treat Chronic Pain (IMPOWR and MIRHIQL)
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RFA-DA-21-030 HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required) Clinical Research in Pain Management Reducing Opioid-Related Harms to Treat Chronic Pain (IMPOWR and MIRHIQL)
no summary
RFA-AT-22-004 HEAL Initiative: Pragmatic and Implementation Studies for the Management of Sickle Cell Disease Pain (UG3/UH3, Clinical Trials Optional) Clinical Research in Pain Management Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM)
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RFA-AT-22-005 HEAL Initiative: Sickle Cell Disease Pain Management Trials Utilizing the Pain Management Effectiveness Research Network Cooperative Agreement (UG3/UH3, Clinical Trial Required) Clinical Research in Pain Management Pain Management Effectiveness Research Network (ERN)
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RFA-AT-22-003 HEAL Initiative: Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management (R61/R33, Clinical Trial Required) Clinical Research in Pain Management Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions
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NOT-AT-22-011 NCCIH Announces Availability of Frequently Asked Questions (FAQs) for RFA-AT-22-003: HEAL Initiative: Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management (R61/R33, Clinical Trial Required) Clinical Research in Pain Management Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions
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RFA-DA-22-036 NIH HEAL Initiative: Preventing Opioid Misuse and Co-Occurring Conditions by Intervening on Social Determinants (R01 Clinical Trials Optional) Clinical Research in Pain Management Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
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RFA-TR-22-012 Emergency Awards: HEAL Initiative-Limited Competition: HEAL Initiative Resource Centers for the Pain Management Effectiveness Research Network (ERN) (U24 Clinical Trial Not Allowed) Clinical Research in Pain Management Pain Management Effectiveness Research Network (ERN)
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RFA-NS-22-037 HEAL Initiative: Advancing Health Equity in Pain and Comorbidities (R61/R33 Clinical Trial Required) Clinical Research in Pain Management Advancing Health Equity in Pain Management
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RFA-NS-22-046 HEAL Initiative: Coordinating Center for National Pain Scientists Career Development (R24 Clinical Trial Not Allowed) Clinical Research in Pain Management Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
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RFA-NS-22-045 HEAL Initiative: National K12 Clinical Pain Career Development Program (K12 Clinical Trial Not Allowed) Clinical Research in Pain Management Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
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RFA-DE-22-011 HEAL Initiative: Secondary Analysis and Integration of Existing Data Related to Acute and Chronic Pain Development or Management in Humans (R21 Clinical Trials Not Allowed) Clinical Research in Pain Management Leveraging Existing and Real-Time Opioid and Pain Management Data
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NOT-NS-22-066 HEAL Initiative: Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements to Support Strategies to Increase Participant Diversity, Inclusion and Engagement in Clinical Studies Clinical Research in Pain Management Advancing Health Equity in Pain Management
no summary
RFA-HD-24-011
HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain: Acute Pain Clinical Trials Program (U01 Clinical Trial Required) Clinical Research in Pain Management Research program not yet identified. Learn about the research led by the NIH Institutes and Centers that are part of the initiative.
Summary:

As part of the NIH's Helping to End Addiction Long-term (HEAL) Initiative, the Eunice Kennedy Shriver National Institute of Child Health and Human Development and participating NIH Institutes and Centers invite applications to this U01 Cooperative Agreement funding opportunity to support innovative, multi-site, large-scale investigator-initiated clinical trials to advance the understanding, assessment, measurement, treatment, and prevention of acute pain in infants, children, and adolescents, including those with disabilities and/or experiencing health disparities.

For more information, please see the technical assistance webinar and FAQ.
OTA-20-008 HEAL Initiative: EPPIC-Net Pain Research - Application for Clinical Trial and Related Activities (OT2) [ROLLING SUBMISSION ACCEPTED: BY INVITATION ONLY] Clinical Research in Pain Management Early Phase Pain Investigation Clinical Network (EPPIC-Net)
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OTA-20-002 HEAL Initiative: EPPIC-Net Pain Research Asset Application – Dossier (OT1) [ROLLING SUBMISSION ACCEPTED: BY INVITATION ONLY] Clinical Research in Pain Management Early Phase Pain Investigation Clinical Network (EPPIC-Net)
no summary