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NOFO # NOFO Title Research Focus Area Earliest Submission Date Expiration Date Posted Date
RFA-AR-25-005
HEAL Initiative: INTERACT INTEgRAtive Back Pain Longitudinal Cohort Teams (UC2 Clinical Trial Optional) Clinical Research in Pain Management Wed, 09/11/2024 Sat, 10/12/2024 Mon, 07/22/2024

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit cooperative agreement applications from interdisciplinary teams to enhance longitudinal data collection and analysis with existing large scale chronic low back pain (cLBP) cohort studies.

This Notice of Fuding Opportunity (NOFO) requires a Plan for Enhancing Diverse Perspectives (PEDP).
RFA-AR-24-007
HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies): Chronic Pain Program (UC2 Clinical Trial Optional) Clinical Research in Pain Management Tue, 10/08/2024 Sat, 11/09/2024 Tue, 07/16/2024

As part of the NIH's Helping to End Addiction Long-term (HEAL) Initiative, the National Institute of Arthritis and Musculoskeletal and Skin Diseases and other participating NIH Institutes and Centers invite applications for the HEAL KIDS Chronic Pain Collaborating Research Teams (HEAL KIDS CPT) Program to conduct interdisciplinary team-based research projects that combine clinical research, novel/cutting-edge technologies, and measurement science, which will improve our understanding of primary and secondary chronic pain conditions in children and adolescents. The results are expected to enhance and expand our capacity to pursue challenging biological problems, therapeutics development, and effective management of pediatric pain conditions.

The HEAL KIDS CPT projects are expected to address a significant scientific challenge in the biopsychosocial model of pain that requires collaboration, synergy, knowledge integration and team interactions. Teams are encouraged to consider transformative objectives and design projects that would lead to new, innovative, and improved strategies to enhance understanding of chronic pain mechanisms at the individual level. Research may include testing of powerful tools, models, and approaches to accelerate the development and translation of pain condition-specific, age-appropriate therapeutics, and next-generation clinical management of pain.

This Notice of Funding Opportunity (NOFO) complements the previously issued NOFO (RFA-HD-24-011) and NOFO (RFA-HD-24-012) focused on clinical trials of acute pain in infants, children, and adolescents and the establishment of a HEAL KIDS Resource Center, respectively.

This Notice of Fuding Opportunity (NOFO) requires a Plan for Enhancing Diverse Perspectives (PEDP).
RFA-NS-24-041
NIH HEAL Initiative: Coordinated Approaches to Pain Care in Health Care Systems (UG3/UH3 - Clinical Trial Optional) Clinical Research in Pain Management Mon, 10/07/2024 Fri, 11/08/2024 Thu, 05/23/2024

This NOFO is intended to embed the coordinated care model under study into the health care delivery system of applicant institutions.  Coordinated pain care approaches proposed for study are expected to include interventions from multiple disciplines as described below and should aim to improve pain management based on the biopsychosocial model of pain. Emphasis should be on reaching populations of patients with greatest need.

Models of coordinated care proposed by the study team should be aligned with health care resources of the participating HCS and should be informed through engagement of stakeholders including patients, providers, healthcare system executives, policymakers, and payors. The study teams are expected to include health care providers from multiple disciplines and implementation scientists.