Find HEAL-Funded Pain Management Clinical Trials

Clinical trials rely on the generosity of patients who participate in research to improve human health. 

  • Learn more about NIH clinical trials.  
  • Check to see if you are eligible to participate in a HEAL clinical trial testing various pain management approaches. Click the trial title to view its entry on

Clinical Trials

A Double-Blind, Randomized, Controlled Trial of Epidural Conus Medullaris Stimulation to Alleviate Pain and Augment Rehabilitation in Patients with Subacute Thoracic Spinal Cord Injury (North Carolina)

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of 80 mg Daily of NRD135S.E1 Versus Placebo in Adult and Elderly Participants With Painful Diabetic Peripheral Neuropathy (California, Florida, Illinois, Massachusetts, New York, Pennsylvania, Virginia, Washington, Wisconsin)

A Sequenced Strategy for Improving Outcomes in Patients With Knee Osteoarthritis Pain (Alabama, Arkansas, California, Colorado, Florida, Georgia, Illinois, Iowa, Maryland, Massachusetts, Minnesota, New York, North Carolina, Ohio, Oregon, Tennessee, Utah, Virginia, Washington)

A Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Knee Osteoarthritis Pain (California, Florida, Massachusetts, Missouri, New York, North Carolina, Pennsylvania, South Carolina, Texas, Washington, Wisconsin)

Effectiveness of an mHealth Psychosocial Intervention to Prevent Transition From Acute to Chronic Postsurgical Pain in Adolescents (Washington, but eligible adolescents across the country undergoing spine surgery may participate)

Enhancing Physical Therapy: Noninvasive Brain Stimulation System for Treating Carpal Tunnel Syndrome (Massachusetts)

Fibromyalgia TENS in Physical Therapy Study (TIPS):An Embedded Pragmatic Clinical Trial (Illinois, Iowa, South Dakota, Wisconsin)

Group-Based Mindfulness for Patients with Chronic Low Back Pain in the Primary Care Setting (Massachusetts)

Home-Based Transcutaneous Electrical Acustimulation for Abdominal Pain (Michigan)

Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease Pain (Florida, Illinois, North Carolina)

Implementing and Evaluating mHealth Pain Coping Skills Training Interventions to Improve Self-Management of Chronic Pain in Cancer Survivors in “Real World” Clinical Practice Setting (Arkansas, California, Colorado, Georgia, Hawaii, Illinois, Iowa, Kentucky, Louisiana, Michigan, Minnesota, Missouri, New Jersey, North Carolina, Ohio, South Carolina, Virginia, Wisconsin)

Integrated Care for Chronic Pain and Opioid Use Disorder: The IMPOWR Research Center at Montefiore/Einstein (IMPOWR-ME) (New York)

Integrated Treatment for Veterans with Co-Occurring Chronic Pain and Opioid Use Disorder (California, Washington, New Mexico)

Integrative Treatment for Achieving Holistic Recovery from Comorbid Chronic Pain and Opioid Use Disorder (Michigan, New Mexico)

Nonpharmacologic Pain Management in FQHC Primary Care Clinics (Utah)

Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain (Alabama, Arkansas, Illinois, Massachusetts, Minnesota, Missouri, New York, Pennsylvania, Texas, Washington)

Proof of Concept Study to Treat Negative Affect in Chronic Low Back Pain (Massachusetts, Minnesota, Pennsylvania)

The Back Pain Consortium Research Program Study (BACPAC) (Michigan)

The BEST Trial: Biomarkers for Evaluating Spine Treatments (BEST) (California, Kansas, Massachusetts, Michigan, North Carolina, Ohio, Pennsylvania, South Carolina, Washington)

Lessons from the Field: Patient and Community Engagement

HEAL prioritizes valuing the perspectives of patients and communities (often called engagement) in research. Scientific solutions for complex conditions like opioid use disorder and pain cannot be effective without knowing if, how, and how well they will work in real people with these conditions. 

Read the Research Spotlight

A Preclinical Researcher's Perspective on Patient and Community Engagement

HEAL is committed to whole-person, patient-centric research that acknowledges all aspects of an individual living with pain or addiction.

Watch the interview

Making a Difference

Read research findings that are making a difference to people’s lives across America through strong partnerships with federal agencies, the private sector, research institutions, and communities.

Read research findings