U.S. Department of Health & Human Services
Find HEAL-Funded Pain Management Clinical Trials
Clinical trials rely on the generosity of patients who participate in research to improve human health.
- Learn more about NIH clinical trials.
- Check to see if you are eligible to participate in a HEAL clinical trial testing various pain management approaches. Click the trial title to view its entry on ClinicalTrials.gov.
Clinical Trials
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of 80 mg Daily of NRD135S.E1 Versus Placebo in Adult and Elderly Participants With Painful Diabetic Peripheral Neuropathy (California, Florida, Illinois, Massachusetts, New York, Pennsylvania, Virginia, Washington, Wisconsin)
A Sequenced Strategy for Improving Outcomes in Patients With Knee Osteoarthritis Pain (Alabama, Arkansas, California, Colorado, Florida, Georgia, Illinois, Iowa, Maryland, Massachusetts, Minnesota, New York, North Carolina, Ohio, Oregon, Tennessee, Utah, Virginia, Washington)
A Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Knee Osteoarthritis Pain (California, Florida, Massachusetts, Missouri, New York, North Carolina, Pennsylvania, South Carolina, Texas, Washington, Wisconsin)
Effectiveness of an mHealth Psychosocial Intervention to Prevent Transition From Acute to Chronic Postsurgical Pain in Adolescents (Washington, but eligible adolescents across the country undergoing spine surgery may participate)
Enhancing Physical Therapy: Noninvasive Brain Stimulation System for Treating Carpal Tunnel Syndrome (Massachusetts)
Fibromyalgia TENS in Physical Therapy Study (TIPS):An Embedded Pragmatic Clinical Trial (Illinois, Iowa, South Dakota, Wisconsin)
Group-Based Mindfulness for Patients with Chronic Low Back Pain in the Primary Care Setting (Massachusetts)
Home-Based Transcutaneous Electrical Acustimulation for Abdominal Pain (Michigan)
Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease Pain (Florida, Illinois, North Carolina)
Implementing and Evaluating mHealth Pain Coping Skills Training Interventions to Improve Self-Management of Chronic Pain in Cancer Survivors in “Real World” Clinical Practice Setting (Arkansas, California, Colorado, Georgia, Hawaii, Illinois, Iowa, Kentucky, Louisiana, Michigan, Minnesota, Missouri, New Jersey, North Carolina, Ohio, South Carolina, Virginia, Wisconsin)
Integrated Treatment for Veterans with Co-Occurring Chronic Pain and Opioid Use Disorder (California, Washington, New Mexico)
Integrative Treatment for Achieving Holistic Recovery from Comorbid Chronic Pain and Opioid Use Disorder (Michigan, New Mexico)
Non-Pharmacological Options in Postoperative Hospital-Based and Rehabilitation Pain Management (NOHARM) Pragmatic Clinical Trial (Florida, Minnesota)
Nonpharmacologic Pain Management in FQHC Primary Care Clinics (Utah)
Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain (Alabama, Arkansas, Illinois, Massachusetts, Minnesota, Missouri, New York, Pennsylvania, Texas, Washington)
Proof of Concept Study to Treat Negative Affect in Chronic Low Back Pain (Massachusetts, Minnesota, Pennsylvania)
The Back Pain Consortium Research Program Study (BACPAC) (Michigan)
The BEST Trial: Biomarkers for Evaluating Spine Treatments (BEST) (California, Kansas, Massachusetts, Michigan, North Carolina, Ohio, Pennsylvania, South Carolina, Washington)