NIH HEAL Initiative 2022 Annual Report

The NIH HEAL Initiative enters its fourth year facing an evolving public health crisis of chronic pain and opioid misuse, addiction, and overdose. The HEAL community encountered another year of pandemic-related impediments but pressed ahead, launching clinical trials and recruiting research participants, and advancing promising targets and devices along the drug development pipeline. HEAL’s research progress, detailed in the 2022 Annual Report, aligns with the U.S. Department of Health and Human Services Overdose Prevention Strategy, and strives to address the wide-ranging needs of people who live with pain and those who use drugs.

HEAL’s impact is ever more apparent, as demonstrated across our 32 programs and described in the annual report. This research builds on progress in fundamental science in the areas of medication development for both pain and substance use disorders, nonpharmacological approaches to pain management, integrating mental health into primary care, and testing multimodal and multidisciplinary systems of care for both pain and addiction. HEAL-funded research continues to advance health equity, acknowledging the vital role an individual’s personal environment plays in drug use, development of chronic pain, and related health outcomes.

Read the full report pdf  834.35 KB.

Previous Annual Reports


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Open Funding Opportunities

The NIH HEAL Initiative® funds work in research focus areas led by most NIH ICs supporting hundreds of projects, from basic science to implementation research.

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About NIH HEAL Initiative®

The Helping to End Addiction Long-term Initiative, or NIH HEAL Initiative® , is an aggressive, trans-agency effort to speed scientific solutions to stem the national opioid public health crisis.

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Research Programs

Research from the Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, includes over 31 distinct programs. These programs are led by most NIH Institutes, Centers, and Offices. 

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