Third Annual NIH HEAL Initiative Investigator Meeting

Presentation slides are available upon request. Please email [email protected].

Day 1 (Monday, April 11, 2022)

10:00 – 10:30 a.m.
Welcome and Introduction
Dr. Rebecca Baker, Director, Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®
Dr. Lawrence Tabak, Acting Director, National Institutes of Health (NIH)

Keynote Address: What Are We Doing, and What Can We Do Better, to End the Overdose Epidemic?
Admiral Rachel L. Levine, M.D., Assistant Secretary for Health, U.S. Department of Health and Human Services

10:30 – 10:45 a.m.
Helping to End Addiction Long-term Initiative: Progress and Priorities
Dr. Rebecca Baker, Director, NIH HEAL Initiative

10:45 – 11:25 a.m.
Dialogue: NINDS and NICHD Directors in Conversation With the HEAL Community Partner Committee
NIH Facilitator: Dr. Rebecca Baker, Director, NIH HEAL Initiative

NIH Discussants: Dr. Walter Koroshetz, Director, National Institute of Neurological Disorders and Stroke (NINDS)
Dr. Diana Bianchi, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

HEAL Community Partner Committee (HCPC) Discussants:
Kevin Charles, Family and Medical Counseling, Inc.
Jessica Hulsey Nickel, Addiction Policy Forum
Bianca Prieto, Georgia Council on Substance Abuse
Philip Rutherford, Faces & Voices of Recovery
Stephanie Smith, Former HEAL Knee Osteoarthritis Study Participant
Christin Veasley, Chronic Pain Research Alliance

11:35 a.m. – 12:30 p.m.

Plenary: At the Intersection of Pain and Opioid Use Disorder—Bringing the Research Communities Together
NIH Facilitators: Dr. Walter Koroshetz, Director, NINDS; and Dr. Nora Volkow, Director, National Institute on Drug Abuse (NIDA)
HEAL Investigator Facilitator:
Assessing and Addressing the Clinical Needs of Patients with Chronic Pain and Opioid Use Disorder
Dr. Declan Barry, Yale School of Medicine

Presentations:
Integrated Approach to Pain and Opioid Use in Hemodialysis Patients
Dr. Manisha Jhamb, University of Pittsburgh
Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR)
Dr. Katie Witkiewitz, University of New Mexico

12:30 – 1:10 p.m.
Fireside Chat: Addressing the Overdose Epidemic From Many Angles
Dr. Rahul Gupta, Director, White House Office of National Drug Control Policy and Dr. Lawrence Tabak, Acting Director, NIH

2:00 – 3:00 p.m.
Discussion Groups

1. Lessons From HEAL Stigma Research
NIH Facilitator: Dr. Wendy Weber, National Center for Complementary and Integrative Health
(NCCIH)
HEAL Investigator Facilitator: Dr. Gavin Bart, University of Minnesota
HCPC Discussant: Stephanie Smith

Presentations:
Behavioral Economics-Based Stigma Reduction Intervention for Low Income, African American Individuals With Opioid Use Disorder
Dr. Karen Derefinko, University of Tennessee
Examining the Effect of Intersectional Stigma on the Treatment of Negative Affect in Chronic Low Back Pain
Rising Star: Dr. Samantha Meints, Brigham and Women’s Hospital

2. Expanding Patient and Community Engagement in HEAL Studies
NIH Facilitator: Dr. Linda Porter, NINDS
HEAL Investigator Facilitator: Dr. Megan Irby, Wake Forest School of Medicine

HCPC Discussant: Christin Veasley, Chronic Pain Research Alliance

Presentations:
Developing a Community-Engaged Research Unit
Dr. Afton Hassett, University of Michigan
HEALthy Brain and Child Development Study
Dr. Cynthia Rogers, Washington University, St. Louis, Missouri

3. Addressing the Unique Needs of Pediatric Populations
NIH Facilitator: Dr. Janani Prabhakar, NIDA
HEAL Investigator Facilitator: Dr. Alice Graham, Oregon Health and Science University

Presentations:
Pediatric Pain and Opioid Prescribing: Disparities, Trends, & Health Literacy
Dr. Deena Chisolm, Nationwide Children’s Hospital, Columbus, Ohio
Data Collection With Pregnant People, Infants, and Young Children​
Rising Star: Dr. Kathryn Humphreys, Vanderbilt University

4. Advances in Digital Therapeutics and Other Technologies
NIH Facilitator: Dr. Will Aklin, NIDA
HEAL Investigator Facilitator: Dr. Suzette Glasner, University of California, Los Angeles

Presentations:
Treating Sickle Cell Pain by Means of Transcranial Focused Ultrasound Neuromodulation
Dr. Bin He, Carnegie-Mellon University
A Prescription Digital Therapeutic to Promote Adherence to Buprenorphine Pharmacotherapy for Patients With Opioid Use Disorder
Dr. Hilary Luderer, Pear Therapeutics, Inc.

5. Improving Access to Medications for Opioid Use Disorder
NIH Facilitator: Dr. Kristen Huntley, NIDA
HEAL Investigator Facilitator: Dr. Edward Nunes, Columbia University

HCPC Discussants: Jessica Hulsey Nickel, Addiction Policy Forum, and Philip Rutherford, Faces & Voices of Recovery

Presentations:
ED-Initiated Buprenorphine for ​Opioid Use Disorder
Dr. Gail D’Onofrio, Yale School of Medicine
What Models Can Tell Us About Ending the Opioid Crisis
Dr. Benjamin Linas, Boston Medical Center
Watch Dr. Linas' presentation

3:00 – 4:00 p.m. (CLOSED TO PUBLIC)
Poster Session and Networking

4:00 – 5:00 p.m.
Scientific Symposium: Advancing Research to Practice
NIH Facilitator: Dr. Helene Langevin, Director, National Center for Complementary and Integrative Health
HEAL Investigator Facilitator: Dr. Donald Penzien, Wake Forest School of Medicine

Presentations:
Recidivism and mortality after in-jail buprenorphine treatment for opioid use disorder
Dr. Elizabeth Evans, University of Massachusetts Amherst
HCS Community Health Campaigns – Shifting from Engagement to Action
Dr. Craig Lefebvre, RTI International
NOHARM: Non-pharmacological Options in post-operative Hospital-based And Rehabilitation pain Management pragmatic trial
Dr. Andrea Cheville, Mayo Clinic Rochester
JCOIN PIERS: Providing Interventions for Enhancing Recovery during Supervision
Rising Star: Dr. Lauren Brinkley-Rubinstein, University of North Carolina at Chapel Hill

5:00 – 5:45 p.m.
NIDA Director, Dr. Nora Volkow in Conversation With Maia Szalavitz, Journalist and Author of Undoing Drugs: The Untold Story of Harm Reduction and the Future of Addiction, and the New York Times Bestseller, Unbroken Brain.

5:45 p.m.
Adjourn

Day 2 (Tuesday, April 12, 2022)

10:00 – 10:10 a.m.
Welcome
Dr. Rebecca Baker, Director, NIH HEAL Initiative®

The Opioid Crisis: Scientific Challenges and Opportunities
Dr. Nora Volkow, Director, NIDA

10:10 – 11:10 a.m.
Scientific Symposium: Advancing the Pain and Addiction Therapeutic Research Pipeline
NIH Facilitator: Dr. Joni Rutter, Director, National Center for Advancing Translational Sciences
HEAL Investigator Facilitator: Dr. Sandra Comer, Columbia University

Presentations:
REINVENT MEDICINE FOR A HEALTHIER WORLD: Weekly Oral Levomethadone
Dr. Richard Scranton, Lyndra Therapeutics
FKBP51 as a promising therapeutic target for the prevention of chronic posttraumatic pain
Dr. Sarah Linnstaedt, University of North Carolina at Chapel Hill
Multi-organ-on-chip Device for Modeling Opioid Reinforcement and Withdrawal, and the Negative Affective Component of Pain: a Therapeutic Screening Tool
Dr. Stephanie Seidlits, University of California, Los Angeles
Rising Star: Dr. Amol Patwardhan, University of Arizona

11:10 a.m. – 12:10 p.m.
Plenary: Better Together—Collective HEALing Through Data Sharing
NIH Facilitator: Dr. Jessica Mazerik, NIH HEAL Initiative
RENCI Facilitator: Dr. Kira Bradford, Renaissance Computing Institute (RENCI), University of North Carolina at Chapel Hill

Presentations:
The case for collaborative, large scale studies and aggressive data sharing policies:  The ABCD Study Data Sharing Model
Dr. Terry Jernigan, University of California San Diego
Data Harmonization of HEAL Prevention Outcomes Studies
Dr. Ty Ridenour, RTI International, University of North Carolina at Chapel Hill
HEAL Pain Common Data Elements (CDE) Program
Dr. Laura Wandner, NINDS
HEAL Data Platform
Dr. Robert Grossman and Dr. Phil Schumm, University of Chicago
HEAL Study-level Core Metadata
Dr. Andrea Tentner, University of Chicago

1:10 – 2:10 p.m. 
Discussion Groups

1. Building the Translational Research Pipeline: Pain Pathways and Biology
NIH Facilitator: Dr. Michael Oshinsky, NINDS
HEAL Investigator Facilitator: Dr. Miriam Goodman, Stanford University

Presentations:
Building the Translational Research Pipeline: ​Implantable Devices for Pain​
Dr. Kip Ludwig, University of Wisconsin-Madison
Discovery and Validation of a Novel Target for Safe and Effective Treatment of Pain​
Dr. Fan Wang, Massachusetts Institute of Technology

2. Better Together: Collaborations in AI and HEAL Data
NIH Facilitator: Dr. Jessica Mazerik,
NIH HEAL Initiative HEAL Data Stewards Facilitators: Dr. Kira Bradford and Chelsea Noyes, RENCI/RTI

Presenters:
Dr. Chris Bizon, RENCI
Dr. Matthew Might, Harvard Medical School

3. Making Treatments More Specific and Effective Through Phenotyping and Biomarkers
NIH Facilitator: Aron Marquitz, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
HEAL Investigator Facilitator: Dr. William Marras, The Ohio State University

HCPC Discussant: Christin Veasley, Chronic Pain Research Alliance

Presentations:
Discovery and Analytical Validation of Inflammatory Biosignatures of the Human Pain Experience
Dr. Alan Prossin, University of Texas Health Science Center at Houston
Discovery and Validation of Prognostic and Robust Biosignatures to Predict Recovery or Persistence in Pediatric Pain
Dr. Laura Simons, Stanford University

4. Helping Individuals With Polysubstance Use and Fentanyl Use: Challenges and Promising Approaches
NIH Facilitator: Dr. Geetha Subramaniam, NIDA
HEAL Investigator Facilitator: Dr. David Fiellin, Yale University

HCPC Discussant: Kayla Zawislak, Addiction Policy Forum

Presentations:
Steps Toward Identifying and Addressing Unhealthy Polysubstance Use in Medical Settings
Dr. Jennifer McNeely, NYU Langone Health
Helping Individuals With Polysubstance Use and Fentanyl Use: Perspectives From the Emergency Department
Rising Star: Dr. Kathryn Hawk, Yale School of Medicine

5. Disparities and Social Determinants of Health
NIH Facilitator: Dr. Aria Crump, NIDA, and Dr. Cheryse Sankar, NINDS
PI Facilitator: Dr. Daniel Dickerson, RAND

HCPC Discussants: Stephanie Smith and Philip Rutherford, Faces & Voices of Recovery

Presentations:
Disparities and SDOH Among Youth Experiencing Homelessness at Risk for Opioid Use Disorder​
Dr. Natasha Slesnick, The Ohio State University
Prospective Observational Study of Postsurgical Pain in Women Undergoing Mastectomy: Postsurgical Pain After Mastectomy (PPAM Study)
Rising Star: Dr. Uchenna Umeh, New York University School of Medicine

2:10 – 3:10 p.m. (CLOSED TO PUBLIC)
Poster Session and Networking

3:10 – 4:00 p.m.
Federal Panel: How Can Science Inform the Federal Response to the Opioid Crisis?
NIH Facilitator: Dr. Lawrence Tabak, Acting Director, NIH

Speakers:
Dr. Robert Califf, Commissioner, U.S. Food and Drug Administration
Dr. Debra Houry, Acting Principal Deputy Director, Centers for Disease Control and Prevention
Dr. Miriam Delphin-Rittmon, Assistant Secretary for Mental Health and Substance Use, Substance Abuse and Mental Health Services Administration

4:00 – 4:30 p.m.
Observations and Future Directions for HEAL
Dr. Rebecca Baker, Director, NIH HEAL Initiative and Dr. Lawrence Tabak, Acting Director, NIH

4:30 p.m.
Adjourn