Funded Projects

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Project #	Project Title	Research Focus Area	Research Program	Administering IC Sort descending	Institution(s)	Investigator(s)	Location(s)	Year Awarded
1R61NR020845-01 Show Summary	Equity Using Interventions for Pain and Depression (EQUIPD)	Clinical Research in Pain Management	Advancing Health Equity in Pain Management	NINR	INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS	MATTHIAS, MARIANNE	Indianapolis, IN	2022
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain and Comorbidities (R61/R33 Clinical Trial Required) NOFO Number: RFA-NS-22-037 Summary: Opioid overdose deaths disproportionately affect Black individuals in the United States. While the use of complementary and integrative pain treatments is effective and widely recommended, Black pain patients (especially those who also have depression) face barriers to the use of these approaches. This project will refine, test, and prepare to implement a novel approach to overcoming these treatment barriers. The research will partner with and empower Black patients to find safe, effective pain treatments that best match their values, preferences, and lifestyles.
3R01NR016681-02S1 Show Summary	MECHANISMS OF MUSIC THERAPY TO PALLIATE PAIN IN PATIENTS WITH ADVANCED CANCER	Clinical Research in Pain Management		NINR	DREXEL UNIVERSITY	BRADT, JOKE	Philadelphia, PA	2018
NOFO Title: Arts-Based Approaches in Palliative Care for Symptom Management (R01) NOFO Number: PAR-14-294 Summary: This study addresses the public health problem of chronic pain as one of the most feared symptoms in people with cancer. Insufficient relief from pharmacological treatments and the fear of side effects are important reasons for the growing use of complementary pain management approaches in people with cancer. One such approach is music therapy. Although efficacy of music therapy for pain has been established, there are no mechanistic studies clarifying how it works in clinical populations. The overarching goals of this study are to 1) examine mediators and moderators hypothesized to account for the pain-reducing effects of interactive music therapy (IMT) in people with advanced cancer and chronic pain and 2) validate IMT’s theory of action. The results of this study will provide estimated effects sizes of IMT on the mediators and preliminary effect size estimates for the pain outcomes. This information will be instrumental in the development of a subsequent large-scale efficacy trial.
1UG3NR020930-01 Show Summary	Adapting and Implementing a Nurse Care Management Model to Care for Rural Patients with Chronic Pain	Clinical Research in Pain Management	Prevention and Management of Chronic Pain in Rural Populations	NINR	UNIVERSITY OF WASHINGTON	TONG, SEBASTIAN (contact); PATEL, KUSHANG	Seattle, WA	2023
NOFO Title: HEAL Initiative: Prevention and Management of Chronic Pain in Rural Populations (UG3/UH3, Clinical Trials Required) NOFO Number: RFA-NR-23-001 Summary: People who live in rural areas have high rates of chronic pain and poor health outcomes and are less likely to receive evidence-based complementary and integrative treatments for chronic pain. This project will adapt a nurse care management model for use in health systems serving rural patients with chronic pain. The research aims to coordinate care, provide cognitive behavioral therapy, and refer patients to a remotely delivered exercise program.
1R43NR017575-01A1 Show Summary	Using Virtual Reality Psychological Therapy to Develop a Non-Opioid Chronic Pain Therapy	Cross-Cutting Research	Small Business Programs	NINR	COGNIFISENSE, INC.	BAEUERLE, TASSILO; CEKO, MARTA ; WEBSTER, LYNN	Sunnyvale, CA	2019
NOFO Title: PHS 2017-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) NOFO Number: PA-17-302 Summary: Chronic pain affects over 100 million Americans, costing society about $600 billion annually. Despite numerous pharmacological and non-pharmacological therapies, over 50% of chronic pain sufferers feel little control over their pain. CognifiSense has developed a patent-pending Virtual Reality Psychological Therapy (VRPT), which is designed to create lasting reduction of chronic pain by addressing the maladaptive learning processes driving pain chronification. VRPT is an experiential learning system, which provides the brain a new set of signals that teaches it that the pain is not as bad as it perceived and that it has greater control over the pain than it perceived. VRPT combines the immersive power and the ability to individualize the therapy of Virtual Reality with well-researched principles of self-distancing, self-efficacy, and extinction to retrain the brain. The goal of this study is to determine the clinical feasibility of VRPT in achieving a lasting reduction of chronic pain, establish brain mechanisms associated with treatment response, and collect comprehensive user feedback to enable further refinement of the current product prototype. CognifiSense's VRPT has the potential to be a significant clinical and business opportunity in the treatment of chronic pain.
1UG3NR020929-01 Show Summary	Reaching Rural Veterans: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention (RAMP-WH)	Clinical Research in Pain Management	Prevention and Management of Chronic Pain in Rural Populations	NINR	CENTER FOR VETERANS RESEARCH AND EDUCATION	BURGESS, DIANA J (contact); EVANS RONI L; HADLANDSMYTH, KATHERINE E	Minneapolis, MN	2023
NOFO Title: HEAL Initiative: Prevention and Management of Chronic Pain in Rural Populations (UG3/UH3, Clinical Trials Required) NOFO Number: RFA-NR-23-001 Summary: This project addresses the significant challenge of providing evidence-based, non-pharmacologic pain management to veterans with chronic pain living in rural regions. This research will test whether an innovative, virtual complementary and integrative group-based treatment will improve rural veterans’ pain management, function, and well-being. The research will also devise, evaluate, and adapt strategies for implementing this intervention while working with the health care system, veteran patients, and communities. The scalable, 12-week intervention includes pain education, mindfulness, pain-specific exercises, and cognitive behavioral strategies.