Funded Projects

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Project #	Project Title	Research Focus Area	Research Program	Administering IC Sort descending	Institution(s)	Investigator(s)	Location(s)	Year Awarded
4R33AT010117-02 Show Summary	Mindful Moms in Recovery: Yoga-based mindfulness relapse prevention for pregnant women with opioid disorder	Translation of Research to Practice for the Treatment of Opioid Addiction	Behavioral Research to Improve Medication-Based Treatment	NCCIH	DARTMOUTH COLLEGE	LORD, SARAH E	Hanover, NH	2019
NOFO Title: Clinical Trials or Observational Studies of Behavioral Interventions for Prevention of Opioid Use Disorder or Adjunct to Medication Assisted Treatment-SAMHSA Opioid STR Grants (R21/R33) NOFO Number: RFA-AT-18-002
1R61AT012279-01 Show Summary	Quantifying and Treating Myofascial Dysfunction in Post Stroke Shoulder Pain	Clinical Research in Pain Management	Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions	NCCIH	JOHNS HOPKINS UNIVERSITY	RAGHAVAN, PREETI	Baltimore, MD	2022
NOFO Title: HEAL Initiative: Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management NOFO Number: RFA-AT-22-003 Summary: Shoulder pain occurs in many patients who are recovering from a stroke. In addition to impairments in the ability to move, persistent shoulder pain contributes to depression, and often reduces quality of life. Although the cause of post-stroke shoulder pain is complex and not completely understood, it is thought to arise in part to damage of muscles and surrounding connective tissues (myofascial tissues) in the shoulder. This project will use advanced medical imaging techniques to create biomarkers of that can reliably identify myofascial tissues. The research will then test the ability of these biomarkers to monitor, and ultimately predict treatment responses in patients with post-stroke shoulder pain in the context of a randomized controlled clinical trial.
1R61AT010614-01 Show Summary	The Youth Opioid Recovery Support (YORS) Intervention: An assertive community treatment model for improving medication adherence in young adults with opioid use disorder	Translation of Research to Practice for the Treatment of Opioid Addiction	Behavioral Research to Improve Medication-Based Treatment	NCCIH	Maryland Treatment Centers	FISHMAN, MARC	Baltimore, MD	2019
NOFO Title: HEAL Initiative: Behavioral Research to Improve MAT: Behavioral and Social Interventions to Improve Adherence to Medication Assisted Treatment for Opioid Use Disorders (R61/R33 Clinical Trial Optional) NOFO Number: RFA-AT-19-006 Summary: Young people are disproportionately affected by the opioid crisis due to lack of access to medications for opioid use disorder (OUD) and poor adherence to these treatments. The Youth Opioid Recovery Support (YORS) model is an innovative wraparound approach that attempts to address barriers to treatment engagement in the young adult population, especially difficulties with medication adherence. The YORS model components include home delivery of extended-release naltrexone for OUD, engagement of families in collaborative treatment planning and monitoring focusing on medication adherence, assertive outreach from the treatment team by text messaging and social media to promote engagement and adherence, and contingency management to provide incentives for medication adherence. If the refining and testing demonstrates the efficacy of the YORS intervention, future work could include an economic analysis, a larger multisite study, longer intervention duration, study of extended-release buprenorphine, and study of step-down to less intensive interventions.
1R61AT010604-01 Show Summary	Testing the Effects of Contingency Management and Behavioral Economics on Buprenorphine-Naloxone Treatment Adherence Using a Sequential Multiple Assignment Randomized Trial (SMART) Design	Translation of Research to Practice for the Treatment of Opioid Addiction	Behavioral Research to Improve Medication-Based Treatment	NCCIH	University of Tennessee	DEREFINKO, KAREN J	Knoxville, TN	2019
NOFO Title: HEAL Initiative: Behavioral Research to Improve MAT: Behavioral and Social Interventions to Improve Adherence to Medication Assisted Treatment for Opioid Use Disorders (R61/R33 Clinical Trial Optional) NOFO Number: RFA-AT-19-006 Summary: This application will develop and execute a sequential multiple assignment randomized trial (SMART) design to test two forms of behavioral economics intervention to promote medication-assisted treatment (MAT) for opioid use disorder. The two interventions, in person, brief motivational interviewing and substance-free activities intervention (BMI+SFAS), initially will be tested for satisfaction and acceptability with participants who are initiating buprenorphine-naloxone treatment and then be tested by SMART for its ability to promote MAT adherence. This innovative SMART design that tests two psychosocial interventions to increase adherence to MAT initiation is likely to have a significant impact on engagement of opioid use disorder patients in treatment and address an underserved population with opioid use disorder who is resistant to MAT adherence.
3R33AT010606-03S1 Show Summary	Adapting the HOPE Online Support Intervention to Increase MAT Uptake Among OUD Patients	Translation of Research to Practice for the Treatment of Opioid Addiction	Behavioral Research to Improve Medication-Based Treatment	NCCIH	UNIVERSITY OF CALIFORNIA-IRVINE	YOUNG, SEAN	Irvine, CA	2021
NOFO Title: HEAL Initiative: Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements to Support Strategies to Increase Participant Diversity, Inclusion and Engagement in Clinical Studies NOFO Number: NOT-NS-21-025 Summary: Effective medications for opioid use disorder (MOUD) are approved by the Food and Drug Administration for the treatment of people with opioid use disorder; however, only a small fraction of patients who would benefit from these medications actually use them. Several reasons contribute to low MOUD use, including lack of insurance; lack of knowledge about the medications, both among patients and providers; stigma associated with MOUD; and social norms. Innovative methods are needed to help increase MOUD use. One such option is peer-led interventions that might increase patients’ interest in MOUD. One existing peer-led intervention is the Harnessing Online Peer Education (HOPE) online community intervention that has been designed to reduce stigma and increase health behavior change among stigmatized populations, such as people living with HIV. This project will investigate whether and how HOPE can be adapted for people with opioid use disorder. It will assess whether HOPE can effectively increase MOUD requests, MOUD uptake, and sustained adherence to MOUD as well as reduce overdose rates.