Funded Projects

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Project #	Project Title	Research Focus Area	Research Program	Administering IC	Institution(s)	Investigator(s)	Location(s) Sort descending	Year Awarded
3U01DE025633-03S1 Show Summary	INVESTIGATION AND MODULATION OF THE MU-OPIOID MECHANISM IN CHRONIC TMD (IN VIVO)	Preclinical and Translational Research in Pain Management		NIDCR	UNIVERSITY OF MICHIGAN AT ANN ARBOR	DASILVA, ALEXANDRE	ANN ARBOR, MI	2018
NOFO Title: Biology of the Temporomandibular Joint in Health and Disease (R01) NOFO Number: PA-14-358 Summary: Initial studies using positron emission tomography (PET) with [11C] carfentanil, a selective radiotracer for ?-opioid receptor (?OR), have demonstrated that there is a decrease in thalamic µOR availability (non-displaceable binding potential BPND) in the brains of TMD patients during masseteric pain compared to healthy controls. ?-opioid neurotransmission is arguably one of the mechanisms most centrally involved in pain regulation and experience. The main goals of our study are: first, to exploit the ?-opioidergic dysfunction in vivo in TMD patients compared to healthy controls; second, to determine whether 10 daily sessions of non-invasive and precise M1 HD-tDCS have a modulatory effect on clinical and experimental pain measures in TMD patients; and third, to investigate whether repetitive active M1 HD-tDCS induces/reverts ?OR BPND changes in the thalamus and other pain-related regions and whether those changes are correlated with TMD pain measures.
1R01AT010797-01 Show Summary	Enhancing the impact of behavioral pain management on MAT outcomes	Translation of Research to Practice for the Treatment of Opioid Addiction	Behavioral Research to Improve Medication-Based Treatment	NCCIH	University of Michigan	ILGEN, MARK A (contact); LIN, LEWEI ALLISON	Ann Arbor, MI	2019
NOFO Title: HEAL Initiative Limited Competition: Behavioral Research to Improve MAT: Ancillary Studies to Enhance Behavioral or Social Interventions to Improve Adherence to Medication Assisted Treatment for Opioid Use Disorders (R01 Clinical Trial Optional) NOFO Number: RFA-AT-19-007 Summary: Chronic pain may be linked to poorer outcomes in those using medication-assisted treatments (MAT) to treat opioid use disorders (OUD). Psychosocial interventions for pain have been effective in patients with chronic pain and substance use disorders, but these interventions have not been thoroughly examined in the OUD population receiving MAT. The study team previously refined and adapted a psychosocial pain management intervention (PPMI) to be delivered by telephone for patients with OUD receiving MAT. The current study will understand the potential applicability of this intervention to other high-risk groups, such as veterans, study the longer-term impact of PPMI, and gather data to inform the implementation of PPMI in MAT patients. This work will provide a robust test of the PPMI intervention to help enhance MAT outcomes in a larger and more representative group of participants while also paving the way for future implementation of interventions to improve MAT retention.
1R21DE032584-01 Show Summary	Identifying Chronic Pain Phenotypes and Treatment Disparities in Adults with Cerebral Palsy	Cross-Cutting Research	Leveraging Existing and Real-Time Opioid and Pain Management Data	NIDCR	UNIVERSITY OF MICHIGAN	PETERSON, MARK D	Ann Arbor, MI	2022
NOFO Title: HEAL Initiative: Secondary Analysis and Integration of Existing Data Related to Acute and Chronic Pain Development or Management in Humans (R21 Clinical Trials Not Allowed) NOFO Number: RFA-DE-22-011 Summary: Cerebral palsy is the most common physical disability in children. Those who have this condition experience pain throughout their lives. Although opioids are generally not recommended, many adults with cerebral palsy are prescribed them for pain. This project will assess the incidence of chronic pain conditions in adults with and without cerebral palsy as well as measure opioid treatment-related health outcomes in adults with cerebral palsy. This research will also evaluate pain treatment disparities related to race/ethnicity and insurance coverage using national medical claims databases.
3R01DA042859-02S1 Show Summary	OPIOIDS: PREVENTION OF IATROGENIC OPIOID DEPENDENCE AFTER SURGERY	New Strategies to Prevent and Treat Opioid Addiction		NIDA	University of Michigan, Ann Arbor	WALJEE, JENNIFER FILIP	ANN ARBOR, MI	2018
NOFO Title: NIH Research Project Grant (Parent R01) NOFO Number: PA-16-160 Summary: Morbidity and mortality related to prescription opioids are accelerating in the United States. Identifying the factors that lead to new opioid dependence among opioid naïve patients is a critical opportunity to reduce prescription opioid dependence and unintended diversion. In the United States, the majority of individuals who become opioid dependent receive their first opioid prescription following surgical procedures, yet there are no clinical guidelines to inform appropriate postoperative opioid use. We will examine the patient factors that are associated with postoperative pain and opioid consumption among a cohort of patients undergoing common elective abdominal procedures. We will identify the provider characteristics in postoperative opioid prescribing practices, and design and implement a provider-directed intervention to optimize postoperative opioid prescribing. Findings will inform patients and providers regarding the risk of opioid dependence following surgery, and will establish a patient-centered data infrastructure that yields continuous feedback to providers regarding appropriate opioid prescribing practices.
1UG3DA050173-01 Show Summary	Optimized Interventions to Prevent Opioid Use Disorder among Adolescents and Young Adults in the Emergency Department	New Strategies to Prevent and Treat Opioid Addiction	Preventing Opioid Use Disorder	NIDA	Univ of Michigan at Ann Arbor	WALTON, MAUREEN A (contact); BONAR, ERIN ELIZABETH	Ann Arbor, MI	2019
NOFO Title: HEAL Initiative: Preventing Opioid Use Disorder in Older Adolescents and Young Adults (ages 16–30) (UG3/UH3 Clinical Trial Required NOFO Number: RFA-DA-19-035 Summary: The emergency department (ED) is an ideal venue to reach and intervene with adolescents and young adults (ages 16-30) at risk for opioid misuse, particularly as young adults may disconnect from primary care when transitioning out of pediatric medicine. This study will evaluate the efficacy of interventions of varying type/intensity to prevent/reduce opioid misuse or opioid use disorder (OUD). The research leverages technology that is appealing to youth to facilitate intervention delivery by health coaches. In this study, adolescents and young adults in the ED screening positive for opioid use or misuse will be randomly assigned to one of four intervention conditions with outcomes measured at 4, 8, and 12 months. Technology-driven, scalable interventions delivered via health coach allow for real-time tailoring to the rapidly changing opioid epidemic, with the potential for a sustainable impact on preventing escalation of opioid misuse among adolescents and young adults.