Funded Projects

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Project # Sort descending	Project Title	Research Focus Area	Research Program	Administering IC	Institution(s)	Investigator(s)	Location(s)	Year Awarded
1R01DA057608-01	Treating Polysubstance Use in Methadone Maintenance: Application of Novel Digital Technology	Translation of Research to Practice for the Treatment of Opioid Addiction	Improving Delivery of Healthcare Services for Polysubstance Use	NIDA	FRIENDS RESEARCH INSTITUTE, INC.	MITCHELL, SHANNON GWIN	Baltimore, MD	2022
NOFO Title: HEAL Initiative: Understanding Polysubstance Use and Improving Service Delivery to Address Polysubstance Use (R01 Clinical Trial Optional) NOFO Number: DA22-047 Summary: Although methadone is an effective treatment for opioid use disorder, many individuals drop out of treatment, putting them at risk of relapse and overdose. One of the factors associated with poor retention in methadone treatment is concurrent cocaine use. There is currently no effective medical treatment for cocaine use disorder. However, contingency management, in which individuals receive tangible rewards for desired behaviors such as abstinence, has been shown to be effective for cocaine use. This project will test the value of a digital therapy app, DynamiCare Health Contingency Management, in methadone treatment programs to promote treatment for polysubstance use.
1R01DA057613-01	Assessing the Reach, Effectiveness, and Implementation of Multiple Harm Reduction Interventions	Translation of Research to Practice for the Treatment of Opioid Addiction	Harm Reduction Approaches to Reduce Overdose Deaths	NIDA	RESEARCH TRIANGLE INSTITUTE	KRAL, ALEXANDER H	Research Triangle Park, NC	2022
NOFO Title: HEAL Initiative: Harm Reduction Policies, Practices, and Modes of Delivery for Persons with Substance Use Disorders (R01 Clinical Trial Optional) NOFO Number: RFA-DA-22-046 Summary: Numerous harm reduction strategies are available to reduce the harmful consequences of drug use. Examples include syringe services programs that provide sterile syringes, easy access to naloxone, and fentanyl test strips that may help people identify whether the substance(s) they plan to take contain fentanyl. This project aims to evaluate the use and effectiveness of several strategies in an urban environment as well as determine the openness and commitment of providers to offering them.
1R01DA057630-01	Predicting Fatal and Non-Fatal Overdose in Los Angeles County with Rapid Overdose Surveillance Dashboard to Target Street-Based Addiction Treatment and Harm Reduction Services	Cross-Cutting Research	Leveraging Existing and Real-Time Opioid and Pain Management Data	NIDA	UNIVERSITY OF CALIFORNIA LOS ANGELES	SHOVER, CHELSEA LEIGH (contact); GOODMAN, DAVID	Los Angeles, CA	2022
NOFO Title: HEAL Initiative: Data and Methods to Address Urgent Needs to Stem the Opioid Epidemic (R01- Clinical Trial Not Allowed) NOFO Number: RFA-DA-22-044 Summary: Effective overdose prevention requires timely, location-specific data to efficiently direct resources and interventions as well as to inform healthcare policy. However, rarely is such information available, resulting in responses that are frequently too late. This project will partner with local government agencies from Los Angeles County, California, to rapidly acquire and analyze information in near real-time from multiple sources to identify overdose hotspots and determine overdose metrics. This information will be used to develop a publicly available Rapid Overdose Surveillance Los Angeles online dashboard with built-in analytics. The dashboard will help determine the scope and specifics of overdose and opioid use in Los Angeles County to help target response and guide mobile addiction treatment and harm reduction services.
1R01DA057631-01	Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement for Tobacco Dependence and Other Drug Use in Methadone Treatment	Translation of Research to Practice for the Treatment of Opioid Addiction	Improving Delivery of Healthcare Services for Polysubstance Use	NIDA	RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL	COOPERMAN, NINA (contact); GARLAND, ERIC LEE	Piscataway, NJ	2022
NOFO Title: HEAL Initiative: Understanding Polysubstance Use and Improving Service Delivery to Address Polysubstance Use (R01 Clinical Trial Optional) NOFO Number: DA22-047 Summary: Although approximately 80% of people with opioid use disorder smoke cigarettes, tobacco use is rarely addressed in treatment of opioid use disorder. Moreover, smoking cessation interventions that are effective in the general population have been minimally effective among people with opioid use disorder. This project will integrate into methadone treatment programs the Mindfulness-Oriented Recovery Enhancement intervention and motivational interviewing to address use of tobacco and other drugs. This research will determine the value of this intervention compared to attending a support group or receiving motivational interviewing. The project will also examine use of tobacco, opioids, and other drugs, and whether people begin treatment. The research will also study implementation barriers and facilitators to the mindfulness-based approach as well as strategies to enhance its adoption into clinical practice.
1R01DA057633-01	Teaching Harm Reduction in Vulnerable Environments (THRIVE): A Peer-Led Intervention Bridging Acute Care Settings and the Discharge to the Community	Translation of Research to Practice for the Treatment of Opioid Addiction	Harm Reduction Approaches to Reduce Overdose Deaths	NIDA	UNIVERSITY OF PITTSBURGH	WILSON, JACQUELINE DEANNA	Pittsburgh, PA	2022
NOFO Title: HEAL Initiative: Harm Reduction Policies, Practices, and Modes of Delivery for Persons with Substance Use Disorders (R01 Clinical Trial Optional) NOFO Number: RFA-DA-22-046 Summary: People who use drugs often have other medical problems that cause them to visit an emergency department frequently. This project will develop and test an intervention aimed at reducing health risk among Black people who use drugs that visit an urban emergency department for care. The intervention will be delivered by people with lived experience of drug use and tailored to meet the unique needs of Black people who use drugs.