Funded Projects

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Project # Sort descending	Project Title	Research Focus Area	Research Program	Administering IC	Institution(s)	Investigator(s)	Location(s)	Year Awarded
1R01DA057443-01	Peer-Delivered, Behavioral Activation Intervention to Improve Polysubstance Use and Retention in Mobile Telemedicine OUD Treatment in an Underserved, Rural Area	Translation of Research to Practice for the Treatment of Opioid Addiction	Improving Delivery of Healthcare Services for Polysubstance Use	NIDA	UNIVERSITY OF MARYLAND, COLLEGE PARK	MAGIDSON, JESSICA F (contact); KATTAKUZHY, SARAH M	College Park, MD	2022
NOFO Title: HEAL Initiative: Understanding Polysubstance Use and Improving Service Delivery to Address Polysubstance Use (R01 Clinical Trial Optional) NOFO Number: DA22-047 Summary: Polysubstance use, especially use of both opioids and stimulants, is compounding the already devastating effects of the opioid crisis in underserved rural areas. This project builds on a previously established treatment model for opioid use disorder that uses telehealth and mobile treatment units, which seeks to engage people in activities they enjoy, to help them avoid negative behaviors such as drug use. This research will evaluate the effectiveness of a behavioral treatment approach delivered by peer recovery support specialists in rural areas and using mobile treatment units. The project will measure the intervention’s effect on treatment retention and polysubstance use – as well as evaluate the intervention’s feasibility, acceptability, adoption, and economic value.
1R01DA057556-01	Disrupting Social Determinants of Health to Improve Substance Use and Mental Health Outcomes for Parents in Rural Regions	New Strategies to Prevent and Treat Opioid Addiction	Preventing Opioid Use Disorder	NIDA	OREGON SOCIAL LEARNING CENTER, INC.	SALDANA, LISA	Eugene, OR	2022
NOFO Title: NIH HEAL Initiative: Preventing Opioid Misuse and Co-Occurring Conditions by Intervening on Social Determinants (R01 Clinical Trials Optional) NOFO Number: RFA-DA-22-036 Summary: Social determinants of health are individual and environmental factors that affect health, the ability to function, and quality of life. This project will study the impact of the family-focused Families Actively Improving Relationships (FAIR) prevention intervention currently offered in rural Oregon counties to parents experiencing substance use and mental health challenges. Through the FAIR program, participants receive substance use treatment services; mental health treatment services; parent management training; and support to access employment, housing, education or to mitigate exposure to violence and discrimination. This research will examine how the FAIR intervention affects substance use and societal determinants of health, toward informing payors and decision makers about the cost and value of FAIR prevention services in rural communities.
1R01DA057591-01	Preferences and Predictors Driving Opioid-Involved Polysubstance Use Profiles and Trajectories: Implications for Improving Care	Translation of Research to Practice for the Treatment of Opioid Addiction	Improving Delivery of Healthcare Services for Polysubstance Use	NIDA	UNIVERSITY OF MICHIGAN	COUGHLIN, LARA NICOLE (contact); LIN, LEWEI ALLISON	Ann Arbor, MI	2022
NOFO Title: HEAL Initiative: Understanding Polysubstance Use and Improving Service Delivery to Address Polysubstance Use (R01 Clinical Trial Optional) NOFO Number: DA22-047 Summary: Little is known about what motivates people to use multiple drugs. Understanding these factors is important for tailoring treatment services. Behavioral economic theory, which determines how much value individuals assign to drugs and potential negative consequences, provides a framework to understand the choices people make. This project will identify patterns, motivating factors, and long-term trajectories of opioid-involved polysubstance use behaviors and treatment. This research will use a range of methods to analyze substance use episodes as well as examine motives and preferences associated with polysubstance use behaviors and how they change over time. The findings will be combined into a toolkit to inform timing, type, and tailoring of interventions and policies to guide implementation of effective clinical strategies and policies for managing polysubstance use in healthcare systems.
1R01DA057599-01	Mining Social Media Big Data for Toxicovigilance: Studying Substance Use via Natural Language Processing and Machine Learning Methods	Cross-Cutting Research	Leveraging Existing and Real-Time Opioid and Pain Management Data	NIDA	EMORY UNIVERSITY	SARKER, ABEED H	Atlanta, GA	2022
NOFO Title: HEAL Initiative: Data and Methods to Address Urgent Needs to Stem the Opioid Epidemic (R01- Clinical Trial Not Allowed) NOFO Number: RFA-DA-22-044 Summary: Monitoring and reporting substance use and substance use disorder is difficult to obtain in real-time using conventional methods. However, social media captures large amounts of data about substance use that are reported by diverse groups of people. Analysis of these data can provide population- or subpopulation-level insights, at low cost and in near real-time. This project aims to convert large amounts of social media data on substance use into actionable knowledge using advanced natural language processing and artificial intelligence approaches. The researchers will publicly release the aggregated statistics through a dedicated dashboard and provide user-friendly, open-source tools to determine trends and analyze disparities.
1R01DA057605-01	Rapid Actionable Data for Opioid Response in Kentucky (RADOR-KY)	Cross-Cutting Research	Leveraging Existing and Real-Time Opioid and Pain Management Data	NIDA	UNIVERSITY OF KENTUCKY	SLAVOVA, SVETLA STEFANOVA (contact); TALBERT, JEFFERY C	Lexington, KY	2022
NOFO Title: HEAL Initiative: Data and Methods to Address Urgent Needs to Stem the Opioid Epidemic (R01- Clinical Trial Not Allowed) NOFO Number: RFA-DA-22-044 Summary: To respond quickly and effectively to the constantly changing dynamics of the opioid crisis, public health agencies and organizations need timely state and local data to make critical decisions about where to allocate resources and target responses. This project creates the Rapid Actionable Data for Opioid Response in Kentucky system, a near real-time statewide surveillance system. This resource will combine data from multiple state agencies to provide actionable and timely information to support opioid overdose prevention, harm reduction, evidence-based treatment, and recovery services. The project will also develop user-driven reporting and visualization tools (mobile and web-based apps) that provide immediate access to near real-time community or state level data, reports, and visual analytics.