|Project #||Project Title Sort descending||Research Focus Area||Research Program||Administering IC(s)||Institution(s)||Investigator(s)||Location(s)||Year Awarded|
|Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease Pain||Clinical Research in Pain Management||Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM)||NCCIH||UNIVERSITY OF ILLINOIS AT CHICAGO||DOORENBOS, ARDITH Z; EZENWA, MIRIAM OMELEBELE; MOLOKIE, ROBERT E; SCHLAEGER, JUDITH MICHELLE; SHAH, NIRMISH R||Chicago, IL||2020|
FOA Title: HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional)
FOA Number: RFA-AT-20-004
In the US, approximately 100,000 people, mainly of African and Hispanic background have Sickle Cell Disease (SCD). Pain is a constant companion and chronic disabling symptom for those with SCD. It is increasingly clear that adults with chronic SCD pain also experience periods of acute worsening of their pain. The evaluation of nonpharmacological therapies that reduce chronic pain and the need for opioid medication among individuals with SCD is critically needed to address lack of adequate pain control to prevent periods of acute deterioration and high opioid use with negative sequelae. The investigators will conduct a hybrid type 1 effectiveness-implementation trial to assess the effectiveness of acupuncture and guided relaxation in patients with SCD while observing and gathering information on implementation in three health systems. The study will utilize a 3-arm, 3-site pragmatic randomized controlled SMART trial design that evaluates adaptive interventions, in which selection of interventions responds to patients? characteristics and evolving clinical status. The investigators will use the Consolidated Framework for Implementation Research to plan, execute, and evaluate implementation processes.