Funded Projects

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Project # Sort descending	Project Title	Research Focus Area	Research Program	Administering IC	Institution(s)	Investigator(s)	Location(s)	Year Awarded
3UG3NS123958-01S1	Neuroimmune Mechanisms of a Humanized CCK-B Receptor scFv as Therapy for Chronic Pain Patients	Cross-Cutting Research	Training the Next Generation of Researchers in HEAL	NINDS	University of New Mexico	WESTLUND-HIGH, KARIN N	Albuquerque, NM	2022
NOFO Title: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp Clinical Trial Not Allowed) NOFO Number: PA21-071 Summary: There are currently few effective therapies available for chronic nerve injury-induced pain, associated anxiety, and depression. This project aims to extend previous research aiming to uncover the mechanism of action of artificially modified immune molecules (humanized cholecystokinin-2 receptor [CCKBR] single-chain variable fragments [scFv]) on human neurons and how it reverses chronic pain and anxiety-like behaviors in mouse models. This potential treatment approach offers important advantages over existing therapies, including extreme specificity, higher affinity, brain/nerve penetrance, safety, and reduced self-immunogenicity.
3UH3AR076387-02S1	Fibromyalgia TENS in Physical Therapy Study (TIPS): An Embedded Pragmatic Clinical Trial: Administrative Supplement	Cross-Cutting Research	Training the Next Generation of Researchers in HEAL	NIAMS	UNIVERSITY OF IOWA	SLUKA, KATHLEEN A; CROFFORD, LESLIE J	Iowa City, IA	2022
NOFO Title: Notice of Special Interest to Encourage Eligible NIH HEAL Initiative Awardees to Apply for Administrative Supplements to Support Career Enhancement Related to Clinical Research on Pain (Admin Supp – Clinical Trial Not Allowed) NOFO Number: NOT-NS-22-087 Summary: This research is using a pragmatic clinical trial to test transcutaneous electrical nerve stimulation in patients with widespread muscle pain and tenderness (fibromyalgia). The research will determine if the addition of TENS to physical therapy reduces pain, increases physical therapy adherence, and helps achieve functional goals with less medication use. This project will involve early career scientists who will gain access to pragmatic research tools as well as develop the skills needed to pursue a career in clinical pain research focused on fibromyalgia.
3UH3AR076573-04S1	Randomized-Controlled Trial of Virtual Reality for Chronic Low-Back Pain to Improve Patient-Reported Outcomes and Physical Activity (HEAL Supplement)	Cross-Cutting Research	Training the Next Generation of Researchers in HEAL	NIAMS	CEDARS-SINAI MEDICAL CENTER	SPIEGEL, BRENNAN	Los Angeles, CA	2022
NOFO Title: Notice of Special Interest to Encourage Eligible NIH HEAL Initiative Awardees to Apply for Administrative Supplements to Support Career Enhancement Related to Clinical Research on Pain (Admin Supp – Clinical Trial Not Allowed) NOFO Number: NOT-NS-22-087 Summary: This research is measuring patient-reported outcomes, unique physical and behavioral characteristics, and opioid use in individuals with chronic low back pain who are using virtual reality (VR) therapy. This project expands the clinical pain workforce by enhancing the ability of an early career clinician to conduct mixed-methods research involving patients using VR technology. This research will contribute new information about barriers to implementing VR technologies across diverse populations, patient preferences for using VR for relief of chronic low back pain.
3UH3AR076724-04S1	Technology Research Site for Advanced, Faster Quantitative Imaging for BACPAC	Cross-Cutting Research	Training the Next Generation of Researchers in HEAL	NIAMS	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	MAJUMDAR, SHARMILA	San Francisco, CA	2022
NOFO Title: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed) NOFO Number: PA-20-222 Summary: Despite the significance of spine disorders, there are few reliable methods to determine appropriate patient care and evaluate intervention effectiveness. The Back Pain Consortium Research Program (BACPAC) is developing machine learning-based methods to obtain disease-related features from biological images. This project supports a scientist from a group underrepresented in biomedicine to expand ongoing research to improve ways to interpret medical data about spine disorders and associated pain.
3UH3AR077360-04S1	A sequenced-strategy for improving outcomes in patients with knee osteoarthritis pain	Cross-Cutting Research	Training the Next Generation of Researchers in HEAL	NIAMS	JOHNS HOPKINS UNIVERSITY	CAMPBELL, CLAUDIA MICHELLE (contact); CASTILLO, RENAN C; COHEN, STEVEN P	Baltimore, MD	2022
NOFO Title: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed) NOFO Number: PA-21-071 Summary: Knee osteoarthritis is one of the leading causes of chronic pain and disability worldwide, affecting more than 30% of older adults. Rates of this condition have more than doubled in the past 70 years and continue to grow sharply, given increases in life expectancy and body mass index among the U.S. population. This project supports a scientist from a group underrepresented in biomedicine to expand ongoing clinical research comparing various non-medication-based treatments for knee osteoarthritis.
3UH3CA261067-03S1	Optimizing the use of ketamine to reduce chronic postsurgical pain	Cross-Cutting Research	Training the Next Generation of Researchers in HEAL	NCI	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	WANG, JING (contact); DOAN, LISA	New York, NY	2022
NOFO Title: HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) NOFO Number: RFA-NS-20-028 Summary: Approximately 20% of patients who undergo surgery develop chronic Postsurgical Pain, which is linked with slow recovery, persistent opioid use and dependence. This project supports a scientist from a group underrepresented in biomedicine to expand ongoing research testing ketamine during and/or after surgery to prevent post-mastectomy pain syndrome. Ketamine is a low-risk treatment option that is easy to implement in a wide range of clinical settings.
3UM1DA049412-04S1	MassHEAL - Reducing overdose deaths by 40% (2019-2023)	Cross-Cutting Research	Training the Next Generation of Researchers in HEAL	NIDA	BOSTON MEDICAL CENTER	SAMET, JEFFREY	Boston, MA	2022
NOFO Title: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed) NOFO Number: PA-21-071 Summary: Although there are effective prevention and treatment programs and services to address opioid misuse, opioid use disorder, and overdose, gaps remain between those needing and those receiving prevention and treatment. There is a need to better understand how to make these programs and services most effective at a local level, a problem being addressed by the HEALing Communities Study. This project supports a scientist from a group underrepresented in biomedicine to continue ongoing work to test the impact of an integrated set of evidence-based practices across health care, behavioral health, justice, and other community-based settings.