HEAL-Supported Research Publications

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About Our Publications

NIH HEAL publications and the primary data behind them promote the dissemination of new knowledge, enhance reproducibility, and accelerate the ability of researchers to build upon NIH HEAL Initiative research to make new discoveries.

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Per HEAL policy, funded projects should make their projects available publicly immediately upon publication in a journal. NIH policy requires acknowledging federal funding when describing projects or programs supported in whole or in part with NIH funds.

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"Research reported in this [publication/press release] was supported by [Helping to End Addiction Long-term^® Initiative, or NIH HEAL Initiative^®] under award number [specific NIH grant number(s) in this format: R01NS123456]." For more information, please visit the HEAL Public Access and Data Sharing page. Send your publications to [email protected] for record keeping.

Current Publications

Translation of Research to Practice for the Treatment of Opioid Addiction

Peer recovery specialist-delivered, behavioral activation intervention to improve retention in methadone treatment: Results from an open-label, Type 1 hybrid effectiveness-implementation pilot trial. Magidson JF, Kleinman MB, Bradley V, Anvari MS, Abidogun TM, Belcher AM, Greenblatt AD, Dean D, Hines A, Seitz-Brown CJ, Wagner M, Bennett M, Felton JW. International Journal of Drug Policy. 2022;108:103813. 10.1016/j.drugpo.2022.103813
The design and conduct of a randomized clinical trial comparing emergency department initiation of sublingual versus a 7-day extended-release injection formulation of buprenorphine for opioid use disorder: Project ED Innovation. D'Onofrio G, Hawk KF, Herring AA, Perrone J, Cowan E, McCormack RP, Dziura J, Taylor RA, Coupet E, Edelman EJ, Pantalon MV, Owens PH, Martel SH, O'Connor PG, Van Veldhuisen P, DeVogel N, Huntley K, Murphy SM, Lofwall MR, Walsh SL, Fiellin DA. Contemp Clin Trials. 2021 May;104:106359. doi: 10.1016/j.cct.2021.106359. Epub 2021 Mar 16. PMID: 33737199. (CTN-0099)
Emergency department-initiated buprenorphine protocols: A national evaluation. Guo CZ, D'Onofrio G, Fiellin DA, Edelman EJ, Hawk K, Herring A, McCormack R, Perrone J, Cowan E. J Am Coll Emerg Physicians Open. 2021 Nov 29;2(6):e12606. doi: 10.1002/emp2.12606. PMID: 34877567; PMCID: PMC8630357. (CTN-0099)

Validation and threshold identification of a prescription drug monitoring program clinical opioid risk metric with the WHO alcohol, smoking, and substance involvement screening test. Cochran G, Brown J, Yu Z, Frede S, Bryan MA, Ferguson A, Bayyari N, Taylor B, Snyder ME, Charron E, Adeoye-Olatunde OA, Ghitza UE, Winhusen T. Drug Alcohol Depend. 2021 Nov 1;228:109067. doi: 10.1016/j.drugalcdep.2021.109067. Epub 2021 Sep 24. PMID: 34610516; PMCID: PMC8612015. (CTN-0093)
Analysis of Health Trajectories Leading to Adverse Opioid-Related Events. Gilson AS, Chartash D, Chang D, Hawk K, D'Onofrio G, Haimovich AD, Fiellin DA, Taylor RA. AMIA Jt Summits Transl Sci Proc. 2021 May 17;2021:248-256. PMID: 34457139; PMCID: PMC8378649.
Clinician Perceptions About a Decision Support System to Identify and Manage Opioid Use Disorder. Solberg LI, Hooker SA, Rossom RC, Bergdall A, Crabtree BF. J Am Board Fam Med. 2021 Nov-Dec;34(6):1096-1102. doi: 10.3122/jabfm.2021.06.210126. PMID: 34772765; PMCID: PMC8759280. (CTN-0095)
The impact of the national stay-at-home order on emergency department visits for suspected opioid overdose during the first wave of the COVID-19 pandemic. Root ED, Slavova S, LaRochelle M, Feaster DJ, Villani J, Defiore-Hyrmer J, El-Bassel N, Ergas R, Gelberg K, Jackson R, Manchester K, Parikh M, Rock P, Walsh SL. Drug Alcohol Depend. 2021 Nov 1;228:108977. doi: 10.1016/j.drugalcdep.2021.108977. Epub 2021 Aug 28. PMID: 34598100; PMCID: PMC8397502.
Disparities in Opioid Overdose Death Trends by Race/Ethnicity, 2018-2019, From the HEALing Communities Study. Larochelle MR, Slavova S, Root ED, Feaster DJ, Ward PJ, Selk SC, Knott C, Villani J, Samet JH. Am J Public Health. 2021 Oct;111(10):1851-1854. doi: 10.2105/AJPH.2021.306431. Epub 2021 Sep 9. PMID: 34499540; PMCID: PMC8561170.
Modifications to the HEALing Communities Study in response to COVID-19 related disruptions. Walters ST, Chandler RK, Clarke T, El-Bassel N, Glasgow LM, Jackson RD, Oga EA, Samet JH, Walsh SL, Zarkin GA. Drug Alcohol Depend. 2021 May 1;222:108669. doi: 10.1016/j.drugalcdep.2021.108669. Epub 2021 Mar 13. PMID: 33761404; PMCID: PMC7954776.
A statewide learning health system to reduce substance use among justice-involved youth in rural communities. Aalsma MC, Aarons GA, Adams ZW, Alton MD, Boustani M, Dir AL, Embi PJ, Grannis S, Hulvershorn LA, Huntsinger D, Lewis CC, Monahan P, Saldana L, Schwartz K, Simon KI, Terry N, Wiehe SE, Zapolski TCB. Alliances to disseminate addiction prevention and treatment (ADAPT): J Subst Abuse Treat. 2021 Sep;128:108368. PMID: 33867210; PMCID: PMC8883586.
Opioid Use Disorder Stigma, Discrimination, and Policy Attitudes in a National Sample of U.S. Young Adults. Adams ZW, Taylor BG, Flanagan E, Kwon E, Johnson-Kwochka AV, Elkington KS, Becan JE, Aalsma MC. J Adolesc Health. 2021 Aug;69(2):321-328. doi: 10.1016/j.jadohealth.2020.12.142. Epub 2021 Feb 10. PMID: 33579622; PMCID: PMC8316251.
Breakthrough SARS-CoV-2 Infections in Prison after Vaccination. Brinkley-Rubinstein L, Peterson M, Martin R, Chan P, Berk J. N Engl J Med. 2021 Sep 9;385(11):1051-1052. doi: 10.1056/NEJMc2108479. Epub 2021 Jul 7. PMID: 34233109; PMCID: PMC8279089.
Increasing Medicaid enrollment among formerly incarcerated adults. Burns ME, Cook ST, Brown L, Tyska S, Westergaard RP. Health Serv Res. 2021 Aug;56(4):643-654. doi: 10.1111/1475-6773.13634. Epub 2021 Feb 9. PMID: 33565117; PMCID: PMC8313952.
Drivers of County Engagement in Criminal Justice-Behavioral Health Initiatives. Cuellar AE, Ramezani N, Breno A, Johnson JE, Taxman FS. Psychiatr Serv. 2021 Oct 13:appips202100485. doi: 10.1176/appi.ps.202100485. Epub ahead of print. PMID: 34644126.
COVID-19 and treating incarcerated populations for opioid use disorder. Donelan CJ, Hayes E, Potee RA, Schwartz L, Evans EA. J Subst Abuse Treat. 2021 May;124:108216. doi: 10.1016/j.jsat.2020.108216. Epub 2020 Dec 2. PMID: 33288348; PMCID: PMC7708799.
Examining the implementation of police-assisted referral programs for substance use disorder services in Massachusetts. Davoust M, Grim V, Hunter A, Jones DK, Rosenbloom D, Stein MD, Drainoni ML. Int J Drug Policy. 2021 Jun;92:103142. doi: 10.1016/j.drugpo.2021.103142. Epub 2021 Feb 2. PMID: 33546937; PMCID: PMC8217104.
Engaging the justice system to address the opioid crisis: The Justice Community Opioid Innovation Network (JCOIN). Ducharme LJ, Wiley TRA, Mulford CF, Su ZI, Zur JB. J Subst Abuse Treat. 2021 Sep;128:108307. doi: 10.1016/j.jsat.2021.108307. Epub 2021 Jan 26. PMID: 33531212.
Stepped-wedge randomized controlled trial of a novel opioid court to improve identification of need and linkage to medications for opioid use disorder treatment for court-involved adults. Elkington KS, Nunes E, Schachar A, Ryan ME, Garcia A, Van DeVelde K, Reilly D, O'Grady M, Williams AR, Tross S, Wilson P, Cohall R, Cohall A, Wainberg M. J Subst Abuse Treat. 2021 Sep;128:108277. doi: 10.1016/j.jsat.2021.108277. Epub 2021 Jan 8. PMID: 33487516; PMCID: PMC8491168.
Massachusetts Justice Community Opioid Innovation Network (MassJCOIN). Evans EA, Stopka TJ, Pivovarova E, Murphy SM, Taxman FS, Ferguson WJ, Bernson D, Santelices C, McCollister KE, Hoskinson R Jr, Lincoln T, Friedmann PD; MassJCOIN Research Group. J Subst Abuse Treat. 2021 Sep;128:108275. doi: 10.1016/j.jsat.2021.108275. Epub 2021 Jan 8. PMID: 33483222; PMCID: PMC8263807.
Recidivism and mortality after in-jail buprenorphine treatment for opioid use disorder. Evans EA, Wilson D, Friedmann PD. Drug Alcohol Depend. 2022 Feb 1;231:109254. doi: 10.1016/j.drugalcdep.2021.109254. Epub 2022 Jan 18. PMID: 35063323; PMCID: PMC8852331.
A clinical protocol of a comparative effectiveness trial of extended-release naltrexone versus extended-release buprenorphine with individuals leaving jail. J Gordon MS, Mitchell SG, Blue TR, Vocci FJ, Fishman MJ, Murphy SM, Couvillion K, Maher K, Ryan D, Wenzel K, Danner ML, Jarvis DK. Subst Abuse Treat. 2021 Sep;128:108241. doi: 10.1016/j.jsat.2020.108241. Epub 2020 Dec 11. PMID: 33339633; PMCID: PMC8898543.
A scoping review of factors that influence opioid overdose prevention for justice-involved populations. Grella CE, Ostlie E, Scott CK, Dennis ML, Carnevale J, Watson DP. Subst Abuse Treat Prev Policy. 2021 Feb 22;16(1):19. doi: 10.1186/s13011-021-00346-1. PMID: 33618744; PMCID: PMC7898779.
Racial disparities in use of non-emergency outpatient care by Medicaid-eligible adults after release from prison: Wisconsin, 2015-2017. Hochstatter KR, Akhtar WZ, El-Bassel N, Westergaard RP, Burns ME. J Subst Abuse Treat. 2021 Jul;126:108484. doi: 10.1016/j.jsat.2021.108484. Epub 2021 May 21. PMID: 34052054; PMCID: PMC8197748.
Changes In Health Services Use After Receipt Of Medications For Opioid Use Disorder In A Statewide Correctional System. Howell BA, Martin RA, Lebeau R, Truong AQ, Wang EA, Rich JD, Clarke JG. Health Aff (Millwood). 2021 Aug;40(8):1304-1311. doi: 10.1377/hlthaff.2020.02156. PMID: 34339247.
The Transitions Clinic Network: Post Incarceration Addiction Treatment, Healthcare, and Social Support (TCN-PATHS): A hybrid type-1 effectiveness trial of enhanced primary care to improve opioid use disorder treatment outcomes following release from jail. Howell BA, Puglisi L, Clark K, Albizu-Garcia C, Ashkin E, Booth T, Brinkley-Rubinstein L, Fiellin DA, Fox AD, Maurer KF, Lin HJ, McCollister K, Murphy S, Morse DS, Shavit S, Wang K, Winkelman T, Wang EA. J Subst Abuse Treat. 2021 Sep;128:108315. doi: 10.1016/j.jsat.2021.108315. Epub 2021 Jan 29. PMID: 33583610; PMCID: PMC8319218.
Justice community opioid innovation network (JCOIN): The TCU research hub. J Knight D, Becan J, Olson D, Davis NP, Jones J, Wiese A, Carey P, Howell D, Knight K. Subst Abuse Treat. 2021 Sep;128:108290. doi: 10.1016/j.jsat.2021.108290. Epub 2021 Jan 15. PMID: 33487517.
Lee JD, Malone M, McDonald R, Cheng A, Vasudevan K, Tofighi B, Garment A, Porter B, Goldfeld KS, Matteo M, Mangat J, Katyal M, Giftos J, MacDonald R. Comparison of Treatment Retention of Adults With Opioid Addiction Managed With Extended-Release Buprenorphine vs Daily Sublingual Buprenorphine-Naloxone at Time of Release From Jail. JAMA Netw Open. 2021 Sep 1;4(9):e2123032. doi: 10.1001/jamanetworkopen.2021.23032. PMID: 34495340; PMCID: PMC8427378.
Using implementation interventions and peer recovery support to improve opioid treatment outcomes in community supervision: Protocol. Martin RA, Stein LAR, Rohsenow DJ, Belenko S, Hurley LE, Clarke JG, Brinkley-Rubinstein L. J Subst Abuse Treat. 2021 Sep;128:108364. doi: 10.1016/j.jsat.2021.108364. Epub 2021 Mar 12. PMID: 33741216; PMCID: PMC8384642.
Optimizing the impact of medications for opioid use disorder at release from prison and jail settings: A microsimulation modeling study. Macmadu A, Adams JW, Bessey SE, Brinkley-Rubinstein L, Martin RA, Clarke JG, Green TC, Rich JD, Marshall BDL. Int J Drug Policy. 2021 May;91:102841. doi: 10.1016/j.drugpo.2020.102841. Epub 2020 Jul 22. PMID: 32712165; PMCID: PMC7790977.
Fostering MOUD use in justice populations: Assessing the comparative effectiveness of two favored implementation strategies to increase MOUD use. Molfenter T, Vechinski J, Taxman FS, Breno AJ, Shaw CC, Perez HA. J Subst Abuse Treat. 2021 Sep;128:108370. doi: 10.1016/j.jsat.2021.108370. Epub 2021 Mar 17. PMID: 33762145; PMCID: PMC8384644.
Strategies to improve implementation of medications for opioid use disorder reported by veterans involved in the legal system: A qualitative study. Morse E, Binswanger IA, Taylor E, Gray C, Stimmel M, Timko C, Harris AHS, Smelson D, Finlay AK. J Subst Abuse Treat. 2021 Oct;129:108353. doi: 10.1016/j.jsat.2021.108353. Epub 2021 Mar 4. PMID: 34080564; PMCID: PMC8380634.
Health economic analyses of the justice community opioid innovation network (JCOIN). Murphy SM, Laiteerapong N, Pho MT, Ryan D, Montoya I, Shireman TI, Huang E, McCollister KE. J Subst Abuse Treat. 2021 Sep;128:108262. doi: 10.1016/j.jsat.2020.108262. Epub 2021 Jan 6. PMID: 33419602; PMCID: PMC8255321.
Reducing Opioid Mortality in Illinois (ROMI): A case management/peer recovery coaching critical time intervention clinical trial protocol. Pho M, Erzouki F, Boodram B, Jimenez AD, Pineros J, Shuman V, Claypool EJ, Bouris AM, Gastala N, Reichert J, Kelly M, Salisbury-Afshar E, Epperson MW, Gibbons RD, Schneider JA, Pollack HA. J Subst Abuse Treat. 2021 Sep;128:108348. doi: 10.1016/j.jsat.2021.108348. Epub 2021 Mar 11. PMID: 33745757.
Partner Seeking and Sexual Behavior in the United States During the COVID-19 Pandemic, March 2020 to March 2021. Rushmore J, Copen CE, Schneider J, Lamuda PSM, Taylor BG, Kirkcaldy RD, Bernstein KT. Sex Transm Dis. 2022 Apr 1;49(4):e57-e60. doi: 10.1097/OLQ.0000000000001582. PMID: 34772895; PMCID: PMC8940666.
National variability in Americans' COVID-19 protective behaviors: Implications for vaccine roll-out. Schneider JA, Taylor BG, Hotton AL, Lamuda PA, Ozik J, Lin Q, Flanagan E, Tuyet Pho M, Kolak M, Brewer R, Pagkas-Bather J, Pollack HA. PLoS One. 2021 Nov 5;16(11):e0259257. doi: 10.1371/journal.pone.0259257. PMID: 34739498; PMCID: PMC8570526.
Improving retention across the OUD service cascade upon reentry from jail using Recovery Management Checkups-Adaptive (RMC-A) experiment. Scott CK, Dennis ML, Grella CE, Watson DP. J Subst Abuse Treat. 2021 Sep;128:108245. doi: 10.1016/j.jsat.2020.108245. Epub 2020 Dec 11. PMID: 33461829; PMCID: PMC8192586.
The impact of the opioid crisis on U.S. state prison systems. Health Scott CK, Dennis ML, Grella CE, Mischel AF, Carnevale J. Justice. 2021 Jul 24;9(1):17. doi: 10.1186/s40352-021-00143-9. PMID: 34304335; PMCID: PMC8310396.
Linking criminal justice-involved individuals to HIV, Hepatitis C, and opioid use disorder prevention and treatment services upon release to the community: Progress, gaps, and future directions. Taweh N, Schlossberg E, Frank C, Nijhawan A, Kuo I, Knight K, Springer SA. Int J Drug Policy. 2021 Oct;96:103283. doi: 10.1016/j.drugpo.2021.103283. Epub 2021 May 18. PMID: 34020864; PMCID: PMC8568621.
Kentucky Women's Justice Community Opioid Innovation Network (JCOIN): A type 1 effectiveness-implementation hybrid trial to increase utilization of medications for opioid use disorder among justice-involved women. Staton M, Webster JM, Leukefeld C, Tillson M, Marks K, Oser C, Bush HM, Fanucchi L, Fallin-Bennett A, Garner BR, McCollister K, Johnson S, Winston E. J Subst Abuse Treat. 2021 Sep;128:108284. doi: 10.1016/j.jsat.2021.108284. Epub 2021 Jan 9. PMID: 33455828; PMCID: PMC8267049.
Social Stigma toward Persons with Opioid Use Disorder: Results from a Nationally Representative Survey of U.S. Adults. Taylor BG, Lamuda PA, Flanagan E, Watts E, Pollack H, Schneider J. Subst Use Misuse. 2021;56(12):1752-1764. doi: 10.1080/10826084.2021.1949611. Epub 2021 Jul 27. PMID: 34315335.
Long-acting buprenorphine vs. naltrexone opioid treatments in CJS-involved adults (EXIT-CJS). Waddell EN, Springer SA, Marsch LA, Farabee D, Schwartz RP, Nyaku A, Reeves R, Goldfeld K, McDonald RD, Malone M, Cheng A, Saunders EC, Monico L, Gryczynski J, Bell K, Harding K, Violette S, Groblewski T, Martin W, Talon K, Beckwith N, Suchocki A, Torralva R, Wisdom JP, Lee JD. J Subst Abuse Treat. 2021 Sep;128:108389. doi: 10.1016/j.jsat.2021.108389. Epub 2021 Apr 8. PMID: 33865691; PMCID: PMC8384640.
Recidivism and mortality after in-jail buprenorphine treatment for opioid use disorder. Evans EA, Wilson D, Friedmann PD. Drug Alcohol Depend. 2022 Feb 1;231:109254. doi: 10.1016/j.drugalcdep.2021.109254. Epub 2022 Jan 18. PMID: 35063323.
Addressing the Opioid Crisis via the Justice System: Study Protocols from the Justice Community Opioid Innovation Network (JCOIN). Edited by Ducharme, L.J., Wiley, T.R.A., Zaller, N. Journal of Substance Abuse Treatment 128 (September 2021).
Disparities in Opioid Overdose Death Trends by Race/Ethnicity, 2018-2019, From the HEALing Communities Study. Larochelle, M.R., Slavova, S., Root, E.D., et al. Am J Public Health. 111(10):1851-1854. (2021). doi: 10.2105/AJPH.2021.306431. Epub 2021 Sep 9. PMID: 34499540; PMCID: PMC8561170.
Protocol for a cluster randomized trial at the community level to reduce opioid overdose deaths through implementation of an integrated set of evidence-based practices. Drug Alcohol Depend. 2020 Dec 1;217:108335. doi: 10.1016/j.drugalcdep.2020.108335. Epub 2020 Oct 17. PMID: 33248391; PMCID: PMC7568493.

New Strategies to Prevent and Treat Opioid Addiction

Optimizing scalable, technology-supported behavioral interventions to prevent opioid misuse among adolescents and young adults in the emergency department: A randomized controlled trial protocol. Bonar EE, Kidwell KM, Bohnert ASB, Bourque CA, Carter PM, Clark SJ, Glantz MD, King CA, Losman ED, McCabe SE, Philyaw-Kotov ML, Prosser LA, Voepel-Lewis T, Zheng K, Walton MA. Contemp Clin Trials. 2021 Sep;108:106523. doi: 10.1016/j.cct.2021.106523. Epub 2021 Aug 2. PMID: 34352386; PMCID: PMC8453131.
Examining the Relationship between Social Connection and Opioid Misuse: A Systematic Review. Cance JD, Saavedra LM, Wondimu B, Scaglione NM, Hairgrove S, Graham PW. Subst Use Misuse. 2021;56(10):1493-1507. doi: 10.1080/10826084.2021.1936056. Epub 2021 Jun 17. PMID: 34139948.
Housing First Combined with Suicide Treatment Education and Prevention (HOME + STEP): study protocol for a randomized controlled trial. Chavez L, Kelleher K, Bunger A, Brackenoff B, Famelia R, Ford J, Feng X, Mallory A, Martin J, Sheftall A, Walsh L, Yilmazer T, Slesnick N. BMC Public Health. 2021 Jun 12;21(1):1128. doi: 10.1186/s12889-021-11133-9. PMID: 34118916; PMCID: PMC8196445.

Enhanced Outcomes for Infants and Children Exposed to Opioids

Eat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal. Young LW, Ounpraseuth ST, Merhar SL, Hu Z, Simon AE, Bremer AA, Lee JY, Das A, Crawford MM, Greenberg RG, Smith PB, Poindexter BB, Higgins RD, Walsh MC, Rice W, Paul DA, Maxwell JR, Telang S, Fung CM, Wright T, Reynolds AM, Hahn DW, Ross J, McAllister JM, Crowley M, Shaikh SK, Puopolo KM, Christ L, Brown J, Riccio J, Wong Ramsey K, Akshatha, Braswell EF, Tucker L, McAlmon KR, Dummula K, Weiner J, White JR, Howell MP, Newman S, Snowden JN, Devlin LA for the ACT NOW Collaborative. New Engl J Med. 2023 April 30; doi10.1056/NEJMoa2214470. Online ahead of print. PMID: 37125831.
Phenobarbital and Clonidine as Secondary Medications for Neonatal Opioid Withdrawal Syndrome. Merhar SL, Ounpraseuth S, Devlin LA, Poindexter BB, Young LW, Berkey SD, Crowley M, Czynski AJ, Kiefer AS, Whalen BL, Das A, Fuller JF, Higgins RD, Thombre V, Lester BM, Smith PB, Newman S, Sánchez PJ, Smith MC, Simon AE; Eunice Kennedy Shriver National Institute Of Child Health And Human Development Neonatal Research Network And The NIH Environmental Influences On Child Health Outcomes (Echo) Program Institutional Development Awards States Pediatric Clinical Trials Network. Pediatrics. 2021 Mar;147(3):e2020017830. doi: 10.1542/peds.2020-017830. PMID: 33632932; PMCID: PMC7919109.
EEG/ERP as a pragmatic method to expand the reach of infant-toddler neuroimaging in HBCD: Promises and challenges. Norton ES, MacNeill LA, Harriott EM, Allen N, Krogh-Jespersen S, Smyser CD, Rogers CE, Smyser TA, Luby J, Wakschlag L. Dev Cogn Neurosci. 2021 Oct;51:100988. doi: 10.1016/j.dcn.2021.100988. Epub 2021 Jul 14. PMID: 34280739; PMCID: PMC8318873.
Remote and at-home data collection: Considerations for the NIH HEALthy Brain and Cognitive Development (HBCD) study. Deoni SCL, D'Sa V, Volpe A, Beauchemin J, Croff JM, Elliott AJ, Pini N, Lucchini M, Fifer WP. Dev Cogn Neurosci. 2022 Jan 6;54:101059. doi: 10.1016/j.dcn.2022.101059. Epub ahead of print. PMID: 35033972; PMCID: PMC8762360.

Novel Therapeutic Options for Opioid Use Disorder and Overdose

Suvorexant ameliorated sleep disturbance, opioid withdrawal, and craving during a buprenorphine taper. Huhn AS, Finan PH, Gamaldo CE, Hammond AS, Umbricht A, Bergeria CL, Strain EC, Dunn KE. Sci Transl Med. 2022 Jun 22;14(650):eabn8238. doi: 10.1126/scitranslmed.abn8238. Epub 2022 Jun 22. PMID: 35731889.

Clinical Research in Pain Management

Biobehavioral Assessments in BACPAC: Recommendations, Rationale, and Methods. Greco CM, Wasan AD, Schneider MJ, Mehling W, Williams DA, Darwin J, Harte SE. Pain Med. 2023 Aug 4;24(Suppl 1):S61-S70. doi: 10.1093/pm/pnac175. PMID: 36370080; PMCID: PMC10403301.
Deep Learning for Multi-Tissue Segmentation and Fully Automatic Personalized Biomechanical Models from BACPAC Clinical Lumbar Spine MRI. Hess M, Allaire B, Gao KT, Tibrewala R, Inamdar G, Bharadwaj U, Chin C, Pedoia V, Bouxsein M, Anderson D, Majumdar S. Pain Med. 2023 Aug 4;24(Suppl 1):S139-S148. doi: 10.1093/pm/pnac142. PMID: 36315069; PMCID: PMC10403305.
Biomechanical Phenotyping of Chronic Low Back Pain: Protocol for BACPAC. Quirk DA, Johnson ME, Anderson DE, Smuck M, Sun R, Matthew R, Bailey J, Marras WS, Bell KM, Darwin J, Bowden AE. Pain Med. 2023 Aug 4;24(Suppl 1):S48-S60. doi: 10.1093/pm/pnac163. PMID: 36315101; PMCID: PMC10403313.
Magnetic resonance imaging of the lumbar spine—recommendations for the acquisition and image evaluation from the BACPAC Spine Imaging Working Group. Sollmann N, Fields AJ, O’Neill C, Nardo L, Majumdar S, Chin CT, Tosun D, Han M, Vu AT, Ozhinsky E, Shah LM, Harris RE, Lobo R, Anderst W, Herzog R, Psioda MA, Standaert CJ, Price RT, Lotz JC, Link TM, Krug R. Pain Med.2022 Sep 7:pnac130. doi:10.1093/pm/pnac 130. PMID 36069660.
The effectiveness of a mindfulness-based intervention integrated with physical therapy (MIND-PT) for post-surgical rehabilitation after lumbar surgery: A protocol for a randomized controlled trial as part of the Back Pain Consortium (BACPAC) research program. Fritz JM, Rhon DI, Garland EL, Hanley AW, Greenlee T, Fino N, Martin B, Highland KB, Greene T. Pain Med. 2022 Sep 7:pnac138. doi: 10.1093/pm/pnac138. PMID: 36069630.

Preclinical and Translational Research in Pain Management

Stimulation of the dorsal root ganglion using an Injectrode^®. Dalrymple AN, Ting JE, Bose R, Trevathan JK, Nieuwoudt S, Lempka SF, Franke M, Ludwig KA, Shoffstall AJ, Fisher LE, Weber DJ J Neural Eng. 2021 Nov 4;18(5). doi: 10.1088/1741-2552/ac2ffb. PMID: 34650008.
Recruitment of Primary Afferents by Dorsal Root Ganglion Stimulation using the Injectrode. Dalrymple AN, Ting JE, Bose R, Nieuwoudt S, Franke M, Ludwig KA, Shoffstall AJ, Fisher LE, Weber DJ. Int IEEE EMBS Conf Neural Eng. 2021 May;2021:609-612. doi: 10.1109/ner49283.2021.9441420. Epub 2021 Jun 2. PMID: 34630868; PMCID: PMC8502004.
An Injectable Neural Stimulation Electrode Made from an In-Body Curing Polymer/Metal Composite. Trevathan JK, Baumgart IW, Nicolai EN, Gosink BA, Asp AJ, Settell ML, Polaconda SR, Malerick KD, Brodnick SK, Zeng W, Knudsen BE, McConico AL, Sanger Z, Lee JH, Aho JM, Suminski AJ, Ross EK, Lujan JL, Weber DJ, Williams JC, Franke M, Ludwig KA, Shoffstall AJ. Adv Healthc Mater. 2019 Dec;8(23):e1900892. doi: 10.1002/adhm.201900892. Epub 2019 Nov 7. PMID: 31697052.

Small Business Innovation Research (SBIR/STTR)

Leveraging digital tools to support recovery from substance use disorder during the COVID-19 pandemic response. McDonnell A, MacNeill C, Chapman B, Gilbertson N, Reinhardt M, Carreiro S. J Subst Abuse Treat. 2021 May;124:108226. doi: 10.1016/j.jsat.2020.108226. Epub 2020 Dec 3. PMID: 33303253; PMCID: PMC8005450.

A Digital Tool to Support Recovery from Substance Use Disorder. Carreiro S, Taylor M, Shrestha S, Reinhardt M, Gilbertson N, Indic P. Realize, Analyze, Engage (RAE): J Psychiatr Brain Sci. 2021;6:e210002. doi: 10.20900/jpbs.20210002. Epub 2021 Feb 24. PMID: 33748430; PMCID: PMC7978415.

An Effective and Safe Novel Treatment of Opioid Use Disorder: Unilateral Transcranial Photobiomodulation. Fredric Schiffer, Alaptagin Khan, Elizabeth Bolger, Edward Flynn, William P Seltzer, Martin H Teicher. Frontiers in Psychiatry. 2021 August; Vol 12 | Article 713686; PMID: 34447323, PMCID: PMC8382852.

Translating Data 2 Action to Prevent Overdose

Antecedents of fatal overdose in an adult cohort identified through administrative record linkage in Indiana, 2015–2022. Ray B, Christian K, Bailey T, Alton M, Proctor A, Haggerty J, Lowder E, Aalsma MC. Drug Alcohol Depend. 2023 June 1;247:109891. doi: 10.1016/j.drugalcde.2023.109891. Epub ahead of print 2023 Apr 22. PMID: 37120921.

Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain

Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief. Hegron A, Peach CJ, Tonello R, Seemann P, Teng S, Latorre R, Huebner H, Weikert D, Rientjes J, Veldhuis NA, Poole DP, Jensen DD, Thomsen ARB, Schmidt BL, Imlach WL, Gmeiner P, Bunnett NW. Proc Natl Acad Sci U S A. 2023 May 22;120(22)e2220979120. doi: 10.1073/pnas.2220979120.

Other

The Helping to End Addiction Long-term (HEAL) Initiative of the National Institutes of Health. Baker, RG; Koroshetz, WJ; Volkow, ND. JAMA. 2021. doi: 10.1001/jama.2021.13300
Helping to End Addiction Over the Long-term: The Research Plan for the NIH HEAL Initiative. Collins FS, Koroshetz WJ, Volkow ND.JAMA. 2018 Jul 10;320(2):129-130. doi: 10.1001/jama.2018.8826.PMID: 29896636 Free PMC article. No abstract available.
The Role of Science in Addressing the Opioid Crisis. Volkow ND, Collins FS.N Engl J Med. 2017 Jul 27;377(4):391-394. doi: 10.1056/NEJMsr1706626. Epub 2017 May 31.PMID: 28564549 Free article. No abstract available.

HEAL-Supported Research Publications

About Our Publications

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Current Publications

Translation of Research to Practice for the Treatment of Opioid Addiction

New Strategies to Prevent and Treat Opioid Addiction

Enhanced Outcomes for Infants and Children Exposed to Opioids

Novel Therapeutic Options for Opioid Use Disorder and Overdose

Clinical Research in Pain Management

Preclinical and Translational Research in Pain Management

Small Business Innovation Research (SBIR/STTR)

Translating Data 2 Action to Prevent Overdose

Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain

Other

Research Programs and Focus Areas

HEAL Public Access and Data Sharing

Common Data Elements (CDE) Program

HEAL-Supported Research Publications

About Our Publications

Add Your Work to This List

Current Publications

Translation of Research to Practice for the Treatment of Opioid Addiction

View More Publications

New Strategies to Prevent and Treat Opioid Addiction

View More Publications

Enhanced Outcomes for Infants and Children Exposed to Opioids

View More Publications

Novel Therapeutic Options for Opioid Use Disorder and Overdose

Clinical Research in Pain Management

View More Publications

Preclinical and Translational Research in Pain Management

View More Publications

Small Business Innovation Research (SBIR/STTR)

View More Publications

Translating Data 2 Action to Prevent Overdose

Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain

Other

Research Programs and Focus Areas

HEAL Public Access and Data Sharing

Common Data Elements (CDE) Program