HEAL-Supported Research Publications

On this page:

• About Our Publications
• Add Your Work to This List
• Current Publications
  • Translation of Research to Practice for the Treatment of Opioid Addiction
  • New Strategies to Prevent and Treat Opioid Addiction
  • Enhanced Outcomes for Infants and Children Exposed to Opioids
  • Novel Therapeutic Options for Opioid Use Disorder and Overdose
  • Clinical Research in Pain Management
  • Preclinical and Translational Research in Pain Management
  • Small Business Innovation Research (SBIR/STTR)
  • Other

About Our Publications

NIH HEAL publications and the primary data behind them promote the dissemination of new knowledge, enhance reproducibility, and accelerate the ability of researchers to build upon NIH HEAL Initiative research to make new discoveries.

Add Your Work to This List

Per HEAL policy, funded projects should make their projects available publicly within 4 weeks of publication in a journal. NIH policy requires acknowledging federal funding when describing projects or programs supported in whole or in part with NIH funds.

Example:

"Research reported in this [publication/press release] was supported by [Helping to End Addiction Long-term^® Initiative, or NIH HEAL Initiative^®] under award number [specific NIH grant number(s) in this format: R01NS123456]."

For more information, please visit the HEAL Public Access and Data Sharing page. Send your publications to [email protected] for record keeping.

Current Publications

Translation of Research to Practice for the Treatment of Opioid Addiction

• Peer recovery specialist-delivered, behavioral activation intervention to improve retention in methadone treatment: Results from an open-label, Type 1 hybrid effectiveness-implementation pilot trial. Magidson JF, Kleinman MB, Bradley V, Anvari MS, Abidogun TM, Belcher AM, Greenblatt AD, Dean D, Hines A, Seitz-Brown CJ, Wagner M, Bennett M, Felton JW. International Journal of Drug Policy. 2022;108:103813. 10.1016/j.drugpo.2022.103813
• The design and conduct of a randomized clinical trial comparing emergency department initiation of sublingual versus a 7-day extended-release injection formulation of buprenorphine for opioid use disorder: Project ED Innovation. D'Onofrio G, Hawk KF, Herring AA, Perrone J, Cowan E, McCormack RP, Dziura J, Taylor RA, Coupet E, Edelman EJ, Pantalon MV, Owens PH, Martel SH, O'Connor PG, Van Veldhuisen P, DeVogel N, Huntley K, Murphy SM, Lofwall MR, Walsh SL, Fiellin DA. Contemp Clin Trials. 2021 May;104:106359. doi: 10.1016/j.cct.2021.106359. Epub 2021 Mar 16. PMID: 33737199. (CTN-0099)
• Emergency department-initiated buprenorphine protocols: A national evaluation. Guo CZ, D'Onofrio G, Fiellin DA, Edelman EJ, Hawk K, Herring A, McCormack R, Perrone J, Cowan E. J Am Coll Emerg Physicians Open. 2021 Nov 29;2(6):e12606. doi: 10.1002/emp2.12606. PMID: 34877567; PMCID: PMC8630357. (CTN-0099)

New Strategies to Prevent and Treat Opioid Addiction

• Optimizing scalable, technology-supported behavioral interventions to prevent opioid misuse among adolescents and young adults in the emergency department: A randomized controlled trial protocol. Bonar EE, Kidwell KM, Bohnert ASB, Bourque CA, Carter PM, Clark SJ, Glantz MD, King CA, Losman ED, McCabe SE, Philyaw-Kotov ML, Prosser LA, Voepel-Lewis T, Zheng K, Walton MA. Contemp Clin Trials. 2021 Sep;108:106523. doi: 10.1016/j.cct.2021.106523. Epub 2021 Aug 2. PMID: 34352386; PMCID: PMC8453131.
• Examining the Relationship between Social Connection and Opioid Misuse: A Systematic Review. Cance JD, Saavedra LM, Wondimu B, Scaglione NM, Hairgrove S, Graham PW. Subst Use Misuse. 2021;56(10):1493-1507. doi: 10.1080/10826084.2021.1936056. Epub 2021 Jun 17. PMID: 34139948.
• Housing First Combined with Suicide Treatment Education and Prevention (HOME + STEP): study protocol for a randomized controlled trial. Chavez L, Kelleher K, Bunger A, Brackenoff B, Famelia R, Ford J, Feng X, Mallory A, Martin J, Sheftall A, Walsh L, Yilmazer T, Slesnick N. BMC Public Health. 2021 Jun 12;21(1):1128. doi: 10.1186/s12889-021-11133-9. PMID: 34118916; PMCID: PMC8196445.

Enhanced Outcomes for Infants and Children Exposed to Opioids

• Phenobarbital and Clonidine as Secondary Medications for Neonatal Opioid Withdrawal Syndrome. Merhar SL, Ounpraseuth S, Devlin LA, Poindexter BB, Young LW, Berkey SD, Crowley M, Czynski AJ, Kiefer AS, Whalen BL, Das A, Fuller JF, Higgins RD, Thombre V, Lester BM, Smith PB, Newman S, Sánchez PJ, Smith MC, Simon AE; Eunice Kennedy Shriver National Institute Of Child Health And Human Development Neonatal Research Network And The NIH Environmental Influences On Child Health Outcomes (Echo) Program Institutional Development Awards States Pediatric Clinical Trials Network. Pediatrics. 2021 Mar;147(3):e2020017830. doi: 10.1542/peds.2020-017830. PMID: 33632932; PMCID: PMC7919109.
• EEG/ERP as a pragmatic method to expand the reach of infant-toddler neuroimaging in HBCD: Promises and challenges. Norton ES, MacNeill LA, Harriott EM, Allen N, Krogh-Jespersen S, Smyser CD, Rogers CE, Smyser TA, Luby J, Wakschlag L. Dev Cogn Neurosci. 2021 Oct;51:100988. doi: 10.1016/j.dcn.2021.100988. Epub 2021 Jul 14. PMID: 34280739; PMCID: PMC8318873.
• Remote and at-home data collection: Considerations for the NIH HEALthy Brain and Cognitive Development (HBCD) study. Deoni SCL, D'Sa V, Volpe A, Beauchemin J, Croff JM, Elliott AJ, Pini N, Lucchini M, Fifer WP. Dev Cogn Neurosci. 2022 Jan 6;54:101059. doi: 10.1016/j.dcn.2022.101059. Epub ahead of print. PMID: 35033972; PMCID: PMC8762360.

Clinical Research in Pain Management

• Biobehavioral assessments in BACPAC: Recommendations, rationale, and methods. Greco CM, Wasan AD, Schneider MJ, Mehling W, Williams DA. Pain Med. 2022 Nov 12;pnac175. doi:10.1093/pm/pnac175. PMID: 36370080.
• Deep learning for multi-tissue segmentation and fully automatic personalized biomechanical models from BACPAC clinical lumbar spine MRI. Hess M, Allaire B, Gao KT, Tibrewala R, Inamdar G, Bharadwaj U, Chin C, Pedoia V, Bouxsein M, Anderson D, Majumdar S. Pain Med. 2022 Oct 31;pnac142. doi://10.1093/p,/pnac142. PMID: 36315069.
• Biomechanical phenotyping of chronic low back pain: Protocol for BACPAC. Quirk DA, Johnson ME, Anderson DE, Smuck M, Sun R, Matthew R, Bailey J, Marras WS, Bell KM, Darwin J, Bowden AE. Pain Med. 2022 Oct 31;pnac163. doi: 10.1093/pm/pnac163. PMID: 36315101
• Magnetic resonance imaging of the lumbar spine—recommendations for the acquisition and image evaluation from the BACPAC Spine Imaging Working Group. Sollmann N, Fields AJ, O’Neill C, Nardo L, Majumdar S, Chin CT, Tosun D, Han M, Vu AT, Ozhinsky E, Shah LM, Harris RE, Lobo R, Anderst W, Herzog R, Psioda MA, Standaert CJ, Price RT, Lotz JC, Link TM, Krug R. Pain Med.2022 Sep 7:pnac130. doi:10.1093/pm/pnac 130. PMID 36069660.
• The effectiveness of a mindfulness-based intervention integrated with physical therapy (MIND-PT) for post-surgical rehabilitation after lumbar surgery: A protocol for a randomized controlled trial as part of the Back Pain Consortium (BACPAC) research program. Fritz JM, Rhon DI, Garland EL, Hanley AW, Greenlee T, Fino N, Martin B, Highland KB, Greene T. Pain Med. 2022 Sep 7:pnac138. doi: 10.1093/pm/pnac138. PMID: 36069630.

Preclinical and Translational Research in Pain Management

• Stimulation of the dorsal root ganglion using an Injectrode^®. Dalrymple AN, Ting JE, Bose R, Trevathan JK, Nieuwoudt S, Lempka SF, Franke M, Ludwig KA, Shoffstall AJ, Fisher LE, Weber DJ J Neural Eng. 2021 Nov 4;18(5). doi: 10.1088/1741-2552/ac2ffb. PMID: 34650008.
• Recruitment of Primary Afferents by Dorsal Root Ganglion Stimulation using the Injectrode. Dalrymple AN, Ting JE, Bose R, Nieuwoudt S, Franke M, Ludwig KA, Shoffstall AJ, Fisher LE, Weber DJ. Int IEEE EMBS Conf Neural Eng. 2021 May;2021:609-612. doi: 10.1109/ner49283.2021.9441420. Epub 2021 Jun 2. PMID: 34630868; PMCID: PMC8502004.
• An Injectable Neural Stimulation Electrode Made from an In-Body Curing Polymer/Metal Composite. Trevathan JK, Baumgart IW, Nicolai EN, Gosink BA, Asp AJ, Settell ML, Polaconda SR, Malerick KD, Brodnick SK, Zeng W, Knudsen BE, McConico AL, Sanger Z, Lee JH, Aho JM, Suminski AJ, Ross EK, Lujan JL, Weber DJ, Williams JC, Franke M, Ludwig KA, Shoffstall AJ. Adv Healthc Mater. 2019 Dec;8(23):e1900892. doi: 10.1002/adhm.201900892. Epub 2019 Nov 7. PMID: 31697052.

Small Business Innovation Research (SBIR/STTR)

• Leveraging digital tools to support recovery from substance use disorder during the COVID-19 pandemic response. McDonnell A, MacNeill C, Chapman B, Gilbertson N, Reinhardt M, Carreiro S. J Subst Abuse Treat. 2021 May;124:108226. doi: 10.1016/j.jsat.2020.108226. Epub 2020 Dec 3. PMID: 33303253; PMCID: PMC8005450.
• A Digital Tool to Support Recovery from Substance Use Disorder. Carreiro S, Taylor M, Shrestha S, Reinhardt M, Gilbertson N, Indic P. Realize, Analyze, Engage (RAE): J Psychiatr Brain Sci. 2021;6:e210002. doi: 10.20900/jpbs.20210002. Epub 2021 Feb 24. PMID: 33748430; PMCID: PMC7978415.
• An Effective and Safe Novel Treatment of Opioid Use Disorder: Unilateral Transcranial Photobiomodulation. Fredric Schiffer, Alaptagin Khan, Elizabeth Bolger, Edward Flynn, William P Seltzer, Martin H Teicher. Frontiers in Psychiatry. 2021 August; Vol 12 | Article 713686; PMID: 34447323, PMCID: PMC8382852.